Walaa N. Ismail^1,2,#,*, Fathimathul Rajeena P. P.^3,#, Mona A. S. Ali^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 3709-3741, 2025, DOI:10.32604/cmes.2025.065564 - 30 June 2025

Abstract Early detection of Alzheimer’s disease (AD) is crucial, particularly in resource-constrained medical settings. This study introduces an optimized deep learning framework that conceptualizes neural networks as computational “sensors” for neurodegenerative diagnosis, incorporating feature selection, selective layer unfreezing, pruning, and algorithmic optimization. An enhanced lightweight hybrid DenseNet201 model is proposed, integrating layer pruning strategies for feature selection and bioinspired optimization techniques, including Genetic Algorithm (GA) and Harris Hawks Optimization (HHO), for hyperparameter tuning. Layer pruning helps identify and eliminate less significant features, while model parameter optimization further enhances performance by fine-tuning critical hyperparameters, improving convergence speed,… More >

M. Vinoth Kumar^1,*, M. Prakash², M. Naresh Kumar³, H. Abdul Shabeer⁴

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 1277-1293, 2023, DOI:10.32604/iasc.2023.025591 - 19 July 2022

Abstract The most noteworthy neurodegenerative disorder nationwide is apparently the Alzheimer's disease (AD) which ha no proven viable treatment till date and despite the clinical trials showing the potential of preclinical therapy, a sensitive method for evaluating the AD has to be developed yet. Due to the correlations between ocular and brain tissue, the eye (retinal blood vessels) has been investigated for predicting the AD. Hence, en enhanced method named Enhanced Long Short Term Memory (E-LSTM) has been proposed in this work which aims at finding the severity of AD from ocular biomarkers. To find the… More >

Anwer Mustafa Hilal¹, Fahd N. Al-Wesabi^2,3, Mohamed Tahar Ben Othman⁴, Khaled Mohamad Almustafa⁵, Nadhem Nemri⁶, Mesfer Al Duhayyim⁷, Manar Ahmed Hamza^1,*, Abu Sarwar Zamani¹

CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 5979-5994, 2022, DOI:10.32604/cmc.2022.022686 - 14 January 2022

Abstract Presently, cognitive Internet of Things (CIoT) with cloud computing (CC) enabled intelligent healthcare models are developed, which enables communication with intelligent devices, sensor modules, and other stakeholders in the healthcare sector to avail effective decision making. On the other hand, Alzheimer disease (AD) is an advanced and degenerative illness which injures the brain cells, and its earlier detection is necessary for suitable interference by healthcare professional. In this aspect, this paper presents a new Oriented Features from Accelerated Segment Test (FAST) with Rotated Binary Robust Independent Elementary Features (BRIEF) Detector (ORB) with optimal artificial neural network… More >

Taher M. Ghazal^1,2, Sagheer Abbas³, Sundus Munir^3,4, M. A. Khan⁵, Munir Ahmad³, Ghassan F. Issa², Syeda Binish Zahra⁴, Muhammad Adnan Khan^6,*, Mohammad Kamrul Hasan¹

CMC-Computers, Materials & Continua, Vol.70, No.3, pp. 5005-5019, 2022, DOI:10.32604/cmc.2022.020866 - 11 October 2021

Abstract Alzheimer's disease is a severe neuron disease that damages brain cells which leads to permanent loss of memory also called dementia. Many people die due to this disease every year because this is not curable but early detection of this disease can help restrain the spread. Alzheimer's is most common in elderly people in the age bracket of 65 and above. An automated system is required for early detection of disease that can detect and classify the disease into multiple Alzheimer classes. Deep learning and machine learning techniques are used to solve many medical problems More >

Himanshu Padole^*, S. D. Joshi, Tapan K. Gandhi

Intelligent Automation & Soft Computing, Vol.31, No.3, pp. 1655-1669, 2022, DOI:10.32604/iasc.2022.021310 - 09 October 2021

Abstract Many methods have been proposed in the literature for diagnosis of Alzheimer's disease (AD) in the early stages, among which the graph-based methods have been more popular, because of their capability to utilize the relational information among different brain regions. Here, we design a novel graph signal processing based integrated AD detection model using multimodal deep learning that simultaneously utilizes both the static and the dynamic brain connectivity based features extracted from resting-state fMRI (rs-fMRI) data to detect AD in the early stages. First, our earlier proposed state-space model (SSM) based graph connectivity dynamics characterization More >