Anwer Mustafa Hilal¹, Fahd N. Al-Wesabi^2,3, Mohamed Tahar Ben Othman⁴, Khaled Mohamad Almustafa⁵, Nadhem Nemri⁶, Mesfer Al Duhayyim⁷, Manar Ahmed Hamza^1,*, Abu Sarwar Zamani¹

CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 5979-5994, 2022, DOI:10.32604/cmc.2022.022686

Abstract Presently, cognitive Internet of Things (CIoT) with cloud computing (CC) enabled intelligent healthcare models are developed, which enables communication with intelligent devices, sensor modules, and other stakeholders in the healthcare sector to avail effective decision making. On the other hand, Alzheimer disease (AD) is an advanced and degenerative illness which injures the brain cells, and its earlier detection is necessary for suitable interference by healthcare professional. In this aspect, this paper presents a new Oriented Features from Accelerated Segment Test (FAST) with Rotated Binary Robust Independent Elementary Features (BRIEF) Detector (ORB) with optimal artificial neural network (ORB-OANN) model for AD diagnosis… More >

MOHAMED AGHYAD AL KABBANI^1,2, GILBERT WUNDERLICH^3,4, CHRISTOPH KöHLER⁵, HANS ZEMPEL^1,2,*

BIOCELL, Vol.46, No.4, pp. 847-853, 2022, DOI:10.32604/biocell.2022.018144

Abstract Tauopathies comprise a spectrum of genetic and sporadic neurodegenerative diseases mainly characterized by the presence of hyperphosphorylated TAU protein aggregations in neurons or glia. Gene therapy, in particular adeno-associated virus (AAV)-based, is an effective medical approach for difficult-to-treat genetic diseases for which there are no convincing traditional therapies, such as tauopathies. Employing AAV-based gene therapy to treat, in particular, genetic tauopathies has many potential therapeutic benefits, but also drawbacks which need to be addressed in order to successfully and efficiently adapt this still unconventional therapy for the various types of tauopathies. In this Viewpoint, we briefly introduce some potentially treatable… More >

Taher M. Ghazal^1,2, Sagheer Abbas³, Sundus Munir^3,4, M. A. Khan⁵, Munir Ahmad³, Ghassan F. Issa², Syeda Binish Zahra⁴, Muhammad Adnan Khan^6,*, Mohammad Kamrul Hasan¹

CMC-Computers, Materials & Continua, Vol.70, No.3, pp. 5005-5019, 2022, DOI:10.32604/cmc.2022.020866

Abstract Alzheimer's disease is a severe neuron disease that damages brain cells which leads to permanent loss of memory also called dementia. Many people die due to this disease every year because this is not curable but early detection of this disease can help restrain the spread. Alzheimer's is most common in elderly people in the age bracket of 65 and above. An automated system is required for early detection of disease that can detect and classify the disease into multiple Alzheimer classes. Deep learning and machine learning techniques are used to solve many medical problems like this. The proposed system… More >