Chunhua YANG1,2,3, Ye TIAN1,2,3
BIOCELL, Vol.43, No.3, pp. 207-214, 2019, DOI:10.32604/biocell.2019.07258
Abstract Sperm-associated antigen 9 (SPAG9) expression is increased in prostate tissues of prostate cancer
patients. This experimental study aimed to investigate the role of SPAG9 in bone metastasis of prostate cancer.
Immunohistochemical analysis showed that SPAG9 staining was positive in 81.67% of 240 cases of prostatic carcinoma
but only in 6.67% of 120 cases of benign prostate hyperplasia. Strong PAG9 staining was positively correlated with
Gleason score and bone metastasis in 240 prostate cancer patients (p < 0.05), but not with the age or serum prostatespecific antigen level (p > 0.05). PC-3 cells were transfected with shRNA against SPAG9, and CCK-8… More >
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