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  • Open Access


    SPAG9 promotes prostate cancer growth and metastasis

    Chunhua YANG1,2,3, Ye TIAN1,2,3

    BIOCELL, Vol.43, No.3, pp. 207-214, 2019, DOI:10.32604/biocell.2019.07258

    Abstract Sperm-associated antigen 9 (SPAG9) expression is increased in prostate tissues of prostate cancer patients. This experimental study aimed to investigate the role of SPAG9 in bone metastasis of prostate cancer. Immunohistochemical analysis showed that SPAG9 staining was positive in 81.67% of 240 cases of prostatic carcinoma but only in 6.67% of 120 cases of benign prostate hyperplasia. Strong PAG9 staining was positively correlated with Gleason score and bone metastasis in 240 prostate cancer patients (p < 0.05), but not with the age or serum prostatespecific antigen level (p > 0.05). PC-3 cells were transfected with shRNA against SPAG9, and CCK-8… More >

  • Open Access


    Shear Stress and Oxidized LDL Regulates Endothelial Cell Tube Formation through VEGF Signaling

    Bo Ling1,#, Daoxi Lei1,#, Juhui Qiu1, Kang Zhang1, Hao Chen2,*, Yeqi Wang1, Zhiyi Ye1, Guixue Wang*

    Molecular & Cellular Biomechanics, Vol.14, No.4, pp. 197-211, 2017, DOI:10.3970/mcb.2017.014.197

    Abstract Shear stress and oxidized low-density lipoprotein (oxLDL) caused by abnormal blood is critical to angiogenesis for atherosclerosis. However, the mechanism in shear stress or ox-LDL regulated angiogenesis is still not well understood. There is the hypothesis that shear stress or oxLDL regulates angiogenesis through the vascular endothelial growth factor (VEGF) signaling pathway. It is discovered that both high shear stress and low concentration of oxLDL contribute to angiogenesis, which is inhibited once the VEGF or VEGFR expression is knocked down. The expression of p-FAK and p-paxillin is regulated by the VEGF/VEGFR signal axis. VEGFR2, p-FAK, p-paxillin and VEGFR1 are VEGF-responsive… More >

  • Open Access


    Shear Stress-mediated Angiogenesis Through Id1 Relevant to Atherosclerosis

    Yidan Chen#,1, Kang Zhang#,1, Juhui Qiu1, Shicheng He1, Junyang Huang2, Lu Huang1, Dongyu Jia3, Bo Ling1, Da Sun4, Xiang Xie1, Tieying Yin*,1, Guixue Wang*,1

    Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 83-100, 2017, DOI:10.3970/mcb.2017.014.081

    Abstract Abnormal shear stress in the blood vessel is an important stimulating factor for the formation of angiogenesis and vulnerable plaques. This paper intended to explore the role of shear stress-regulated Id1 in angiogenesis. First, we applied a carotid artery ring ligation to create local stenosis in ApoE-/- mice. Then, 3D geometry of the vessel network was reconstructed based on MRI, and our analysis of computational fluid dynamics revealed that wall shear stress of the proximal region was much higher than that of the distal region. In addition, results from histological staining of the proximal region found more vulnerable-probe plaques with… More >

  • Open Access


    Simulation of 3D Solid Tumour Angiogenesis Including Arteriole, Capillary and Venule

    Jie Wu∗,†, Quan Long, Shixiong Xu*, Anwar R. Padhani§, Yuping Jiang

    Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 217-228, 2008, DOI:10.3970/mcb.2008.005.217

    Abstract In this paper, a 3D mathematical model of tumour angiogenesis is developed, to generate a functional tumour vasculature for blood microcirculation. The model follows that of Anderson and Chaplain (1998) [1] with three exceptions: (a) extending the model from 2D to 3D, one arteriole and one venule is induced as two parent vessels to form an intact circulation network for blood flow; (b) generating networks able to penetrate into the tumour interior rather than the exterior only; (c) considering branching generations with different diameters, based on which three groups of vessels, such as arterioles, venules and capillaries are classified. The… More >

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