LING MA1,#, ZIRUI JIANG1,#, XIAO HOU1, YUTING XU1, ZIYUN CHEN1, SIYI ZHANG1, HANXUE LI1, SHAOJIE MA1, GENG ZHANG2, XIUJUN WANG1,*, JING JI1,*
BIOCELL, Vol.48, No.5, pp. 847-860, 2024, DOI:10.32604/biocell.2024.050868
Abstract Background: Regulatory proteins involved in human cellular division and proliferation, cyclin-dependent kinases 4 and 6 (CDK4/6) are overexpressed in numerous cancers, including triple-negative breast cancer (TNBC). TNBC is a common pathological subtype of breast cancer that is prone to recurrence and metastasis, and has a single treatment method. As one of the CDK4/6 inhibitors, abemaciclib can effectively inhibit the growth of breast tumors. In this study, we synthesized LA-D-B1, a derivative of Abemaciclib, and investigated its anti-tumor effects in breast cancer. Methods: Cellular viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cloning and migration abilities were determined by… More >
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