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  • Open Access


    The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer

    Jie Wei*†1, Yuanliang Yan*†1, Xi Chen*†, Long Qian*†, Shuangshuang Zeng*†, Zhi Li, Shuang Dai*†, Zhicheng Gong*†,Zhijie Xu§

    Oncology Research, Vol.27, No.7, pp. 849-858, 2019, DOI:10.3727/096504018X15447833065047

    Abstract Over the past decade, natural compounds have been proven to be effective against many human diseases, including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. An increasing number of studies have emphasized the antitumor effects of TPL on non-small cell lung cancer (NSCLC). Here we mainly focused on the key molecular signaling pathways that lead to the inhibitory effects of TPL on human NSCLC, such as mitogen-activated protein kinases (MAPKs) modulation, inhibition of NF- B activation, suppression of miRNA expression, etc. In addition, the effect… More >

  • Open Access


    Sulforaphane: Expected to Become a Novel Antitumor Compound

    Geting Wu*1, Yuanliang Yan†‡1, Yangying Zhou§, Yumei Duan*, Shuangshuang Zeng†‡, Xiang Wang†‡, Wei Lin*, Chunlin Ou*, Jianhua Zhou*, Zhijie Xu*‡

    Oncology Research, Vol.28, No.4, pp. 439-446, 2020, DOI:10.3727/096504020X15828892654385

    Abstract Natural products are becoming increasingly popular in a variety of traditional, complementary, and alternative systems due to their potency and slight side effects. Natural compounds have been shown to be effective against many human diseases, especially cancers. Sulforaphane (SFE) is a traditional Chinese herbal medicine. In recent years, an increasing number of studies have been conducted to evaluate the antitumor effect of SFE. The roles of SFE in cancers are mainly through the regulation of potential biomarkers to activate or inhibit related signaling pathways. SFE has exhibited promising inhibitory effects on breast cancer, lung cancer, liver cancer, and other malignant… More >

  • Open Access


    IL-24-Armed Oncolytic Vaccinia Virus Exerts Potent Antitumor Effects via Multiple Pathways in Colorectal Cancer

    Lili Deng*1, Xue Yang†1, Jun Fan*, Yuedi Ding*, Ying Peng*, Dong Xu*, Biao Huang*‡, Zhigang Hu

    Oncology Research, Vol.28, No.6, pp. 579-590, 2020, DOI:10.3727/096504020X15942028641011

    Abstract Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus is being developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (IL-24) is an important immune mediator, as well as a broad-spectrum tumor suppressor. We constructed a targeted vaccinia virus of Guang9 strain harboring IL-24 (VG9-IL-24) to evaluate its antitumor effects. In vitro, VG9-IL-24 induced an increased number of apoptotic cells and blocked colorectal cancer cells in the G2 /M phase of the cell cycle. VG9-IL-24 induced apoptosis in… More >

  • Open Access


    The antitumor effects of Newcastle disease virus on glioma

    Ji SHI; Peixin SUN, Ye ZHANG, Bing YAO, Haozhe PIAO

    BIOCELL, Vol.43, No.3, pp. 119-128, 2019, DOI:10.32604/biocell.2019.07577

    Abstract Glioma is the most common primary malignant brain tumor with a poor survival rate. In recent years, no significant progress has been made in the treatment of gliomas in contrast to the development of improved diagnosis via molecular typing. Newcastle disease virus (NDV), a negative-stranded RNA virus that exhibits oncolytic activity, has been investigated for its capacity to elicit antitumor activity in many types of cancers, including glioma. Therefore, application of oncolytic viruses, such as NDV, as a new treatment strategy to specifically target aberrant signaling in glioblastomas has brought new hope. For many years, NDV has been investigated for… More >

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