SUNG HEE LIM^1,#, HEE JIN CHO^1,2,3,#, KYOUNG-MEE KIM⁴, HO YEONG LIM¹, WON KI KANG¹, JEEYUN LEE¹, YOUNG SUK PARK¹, HEE CHEOL KIM^5,*, SEUNG TAE KIM^1,*

Oncology Research, Vol.31, No.6, pp. 855-866, 2023, DOI:10.32604/or.2023.030374

Abstract Background: Although bevacizumab is an important treatment for metastatic colorectal cancer (CRC), not all patients with CRC benefit from it; in unselected patient populations, only modest survival benefits have been reported. Methods: We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identify biomarkers for a response to bevacizumab-containing treatment. The molecular analysis comprised whole-exome sequencing, ribonucleic acid sequencing, and a methylation array on patient tissues. Results: Genomic and molecular characterization was successfully conducted in 103 patients. Six of 103 CRC samples were hypermutated, and none of the non-hypermutant tumors were microsatellite unstable. Among those 103 patients, 89… More >

Tsung-Kun Chang^*†, Tzu-Chieh Yin^‡§, Wei-Chih Su^*†, Hsiang-Lin Tsai^*¶, Ching-Wen Huang^*¶, Yen-Cheng Chen^*, Ching-Chun Li^*, Po-Jung Chen^*, Cheng-Jen Ma^*§, Kuo-Hsiang Chuang^#, Tian-Lu Cheng^**, Jaw-Yuan Wang^{*†¶††‡‡§§}

Oncology Research, Vol.28, No.7-8, pp. 801-809, 2020, DOI:10.3727/096504021X16218531628569

Abstract Irinotecan, a topoisomerase inhibitor, is a common cytotoxic agent prescribed for metastatic colorectal cancer (mCRC) patients. Diarrhea is the most common adverse event (AE). The underlying mechanism of irinotecaninduced diarrhea is intestinal mucosal damage caused by SN-38 (active metabolite of irinotecan) hydrolyzed from SN-38G (inactive metabolite) by bacterial -glucuronidase ( G). According to an animal study, silymarin reduces the activity of bacterial G without impairing antitumor efficacy. We conducted a prospective openlabel pilot study to evaluate the effect of silymarin as supplementation in reducing toxicities of mCRC patients undergoing irinotecan-based chemotherapy. We enrolled and randomized 70 mCRC patients receiving first-line… More >

Hsiang-Lin Tsai^*†, Yen-Cheng Chen^*‡, Tzu-Chieh Yin^*§¶, Wei-Chih Su^*‡, Po-Jung Chen^*,Tsung-Kun Chang^*†, Ching-Chun Li^*, Ching-Wen Huang^*†, Jaw-Yuan Wang^{*†‡#**††‡‡}

Oncology Research, Vol.29, No.1, pp. 47-61, 2021, DOI:10.3727/096504022X16451187313084

Abstract Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) polymorphism plays a crucial role in the increased susceptibility and toxicity of patients to irinotecan. This retrospective, observational study compared the clinical outcomes and adverse events (AEs) in RAS wild-type metastatic colorectal cancer (mCRC) patients treated with cetuximab or bevacizumab plus FOLFIRI with UGT1A1 genotyping and irinotecan dose escalation as the first-line therapy. In total, 173 patients with mCRC with RAS wild-type were enrolled. Among them, 98 patients were treated with cetuximab, whereas 75 patients were treated with bevacizumab. All patients received irinotecan dose escalation based on UGT1A1 genotyping. We compared the progression-free survival (PFS),… More >

Jung-Fa Tsai¹, Ngoc Huyen Nguyen¹, Ming-Hua Lin^2,*

CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 3575-3593, 2022, DOI:10.32604/cmc.2022.030476

Abstract During the last decade, the food and beverage industry has been one of the most significant and prioritized industries that contributed to the economic growth in Vietnam. Therefore, how to enhance the performance of food and beverage firms has become a critical factor for Vietnam’s economic development. This research aims to use the data envelopment analysis (DEA) and the Malmquist productivity index (MPI) to assess changes in operational performance and productivity of listed lead food and beverage firms in Vietnam during the period between 2015 and 2020. The obtained results reveal that Vietnamese food and beverage firms were generally inefficient… More >

Benedikt Plaumann^*

Sound & Vibration, Vol.56, No.1, pp. 1-19, 2022, DOI:10.32604/sv.2022.018634

Abstract This contribution shows an analysis of vibration measurement on large floor-mounted traction batteries of Battery Electric Vehicles (BEV). The focus lies on the requirements for a realistic replication of the mechanical environments in a testing laboratory. Especially the analysis on global bending transfer functions and local corner bending coherence indicate that neither a fully stiff fixation of the battery nor a completely independent movement on the four corners yields a realistic and conservative test scenario. The contribution will further show what implication these findings have on future vibration & shock testing equipment for large traction batteries. Additionally, it will cover… More >

Junding Sun^1,3,#, Xiang Li^1,#, Chaosheng Tang^1,*, Shixin Chen^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.129, No.2, pp. 729-753, 2021, DOI:10.32604/cmes.2021.016416

Abstract Purpose: As to January 11, 2021, coronavirus disease (COVID-19) has caused more than 2 million deaths worldwide. Mainly diagnostic methods of COVID-19 are: (i) nucleic acid testing. This method requires high requirements on the sample testing environment. When collecting samples, staff are in a susceptible environment, which increases the risk of infection. (ii) chest computed tomography. The cost of it is high and some radiation in the scan process. (iii) chest X-ray images. It has the advantages of fast imaging, higher spatial recognition than chest computed tomography. Therefore, our team chose the chest X-ray images as the experimental dataset in… More >

Muddasar Khan¹, Cesar Levy¹, Amer Hameed¹, Zulfiqar Khan¹, Khalid Orakzai¹, Musarrat Khan¹, Khuram Shahazad¹, Afzaal M.Malik¹, Shahab Khushnood¹

Structural Durability & Health Monitoring, Vol.6, No.2, pp. 53-68, 2010, DOI:10.3970/sdhm.2010.006.053

Abstract Aluminum metal beverage container is used in packaging foods and chemical industries because of its superior hold, formability, corrosion resistance and join ability. The 80 percent of the container cost is material and aluminum metal is expansive one. The beverage container industry is struggling for potential saving from weight reduction in each container, while meeting the three structural performance standards which have been established to assess the adequacy of the container design. These are axial column load, drop resistance and internal pressure. This paper relates to the internal pressure standard which states that container must withstand at least 90-100PSI or… More >