CHAO WANG^1,2, JUNWEI WANG¹, FANQIAN SONG^1,2, HANRUO LIU³, LIYAO SUN^1,2, XI WEI^1,2, TAO ZHENG¹, HUA QIAN², XIAOGUANG LI², WEIHUA ZHANG⁴, XIANLING TANG^1,*, PING LIU^1,*

BIOCELL, Vol.47, No.1, pp. 143-154, 2023, DOI:10.32604/biocell.2023.023585

Abstract Objective: Age-relate cataract (ARC) is a disease of the eyes with no effective drugs to prevent or treat patients. The aim of the present study is to determine whether histone H3, αA-crystallin (CRYAA), β-galactosidase (GLB1), and p53 are involved in the pathogenesis of ARC. Methods: A total of 99 anterior lens capsules (ALCs) of patients with ARC of various nuclear grades, ultraviolet models of ALCs, and two human lens epithelial cell lines (FHL-124 and SRA01/04) were used, and the expression of histone H3, CRYAA, GLB1, and p53 were detected by immunoblotting and reverse transcription and real time-quantitative polymerase chain reaction.… More >

SHELDON R. GORDON^*

BIOCELL, Vol.46, No.9, pp. 2059-2063, 2022, DOI:10.32604/biocell.2022.019873

Abstract Much of our understanding of the events which underlie cell migration has been derived from studies of cells in tissue culture. One of the components that mediates this process is the dynamic actin-based microfilament system that can reorganize itself into so-called stress fibers that are considered essential components for cell motility. In contrast, relatively few studies have investigated cell movement along an extracellular matrix (ECM) which is known to influence both cellular organization and behavior. This opinion/viewpoint article briefly reviews cell migration during corneal endothelial wound repair along the tissue’s natural basement membrane, Descemet’s membrane. Because the tissue exists as… More >