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    ARTICLE

    Isolation, purification and structure elucidation of three new bioactive secondary metabolites from Streptomyces lividans AM

    MOHAMMAD EL-METWALLY1,*, MAMDOUH ABDEL-MOGIB2, MANAL ELFEDAWY2, GAAD SOHSAH2, AHMED REZK3, MAHMOUD MOUSTAFA4, MOHAMED SHAABAN5,6

    BIOCELL, Vol.45, No.5, pp. 1263-1271, 2021, DOI:10.32604/biocell.2021.013198 - 12 July 2021

    Abstract Microorganisms are a huge mine of bioactive metabolites, and actinomycetes are one of the very active groups in this area. In this article, we are concerned about the full taxonomical characterization of Streptomyces lividans AM, isolated from Egyptian soil. This isolate produced three new bioactive metabolites, namely: 1-Nona-decanoyl,4-oleyl disuccinate (1), filoboletic acid; (9Z,11E)-8,13-dihydroxy octadeca-9,11-dienoic acid (2), and sitosteryl-3β-D-glucoside (3). Extensive 1D and 2D NMR and HR-mass spectrometry were used to elucidate the structures of the three compounds. Moreover, ten known compounds were also identified. The antimicrobial activity of the producing organism and newly reported compounds (1–3) More >

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