Savio L-Y. Woo^∗,†, Matthew B. Fisher^†, Andrew J. Feola^†

Molecular & Cellular Biomechanics, Vol.5, No.1, pp. 49-68, 2008, DOI:10.3970/mcb.2008.005.049

Abstract The contribution of biomechanics to the advancement of management of ligament and tendon injuries has been significant. Thanks to Professor Y.C. Fung's writing and guidance, our field of research has done fundamental work on anatomy and biology of ligaments and tendons, developed methods to accurately determine mechanical properties, identified various experimental factors which could change the outcome measurements as well as examined biological factors that change tissue properties in-vivo. Professor Fung also gave us his quasi-linear viscoelastic theory for soft tissues so that the time and history dependent properties of ligaments and tendons could be More >

Christine M. Scotti¹, Sergio L. Cornejo², Ender A. Finol³

The International Conference on Computational & Experimental Engineering and Sciences, Vol.1, No.1, pp. 41-48, 2007, DOI:10.3970/icces.2007.001.041

Abstract Abdominal aortic aneurysm (AAA) rupture is believed to represent the culmination of a complex vascular mechanism partially driven by the forces exerted on the arterial wall. In the present investigation, we present fully coupled fluid-structure interaction (FSI) and finite element analysis (FEA) computations of a patient-specific AAA model. This work advances previous FSI AAA modeling by including localized intraluminal thrombus and the comparison of FSI- and FEA-predicted wall stress distributions. The FSI transient fluid and wall dynamics resulted in a maximum wall stress 21% higher than that obtained with FEA, demonstrating the importance of modeling More >

Guanbin Song^∗,†,‡, Yang Ju^∗,†,§, Hitoshi Soyama^*, Toshiro Ohashi^¶, Masaaki Sato^¶

Molecular & Cellular Biomechanics, Vol.4, No.4, pp. 201-210, 2007, DOI:10.3970/mcb.2007.004.201

Abstract Mechanical stimulation is critical to both physiological and pathological states of living cells. Although a great deal of research has been done on biological and biochemical regulation of the behavior of bone marrow mesenchymal stem cells (MSCs), the influence of biomechanical factors on their behavior is still not fully documented. In this study, we investigated the modulation of mechanical stretch magnitude, frequency, and duration on the human marrow mesenchymal stem cells (hMSCs) proliferation by an in vitro model system using a mechanical stretch loading apparatus, and optimized the stretch regime for the proliferation of hMSCs.… More >

V. S. Nirmalanandhan¹, J. T. Shearn¹, N. Juncosa-Melvin¹, M. Rao¹, A. Jain¹, C. Gooch¹, D. L. Butler¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 131-134, 2006, DOI:10.32604/mcb.2006.003.131

Abstract This article has no abstract. More >

Wendong Shi^∗,†, Xi-Qiao Feng^*, Huajian Gao^†

Molecular & Cellular Biomechanics, Vol.3, No.3, pp. 121-126, 2006, DOI:10.3970/mcb.2006.003.121

Abstract When pulling a vesicle adhered on a substrate, both the force-displacement profile and the maximum force at pull-off are sensitively dependent upon the substrate shape. Here we consider the adhesion between a two-dimensional vesicle and a rigid substrate via long-range molecular interactions. For a given contact area, the theoretical pull-off force of the vesicle is obtained by multiplying the theoretical strength of adhesion and the contact area. It is shown that one may design an optimal substrate shape to achieve the theoretical pull-off force. More >

Quang Dang^1,1, Hans Gregersen^2,2, Birgitte Duch^2,2, Ghassan S. Kassab^1,1

Molecular & Cellular Biomechanics, Vol.2, No.2, pp. 53-62, 2005, DOI:10.3970/mcb.2005.002.053

Abstract Biliary duct obstruction is an important clinical condition that affects millions of people worldwide. We have previously shown that the common bile duct (CBD) undergoes significant growth and remodelling post obstruction. The mechanical stress-strain relation is expected to change due to growth and remodeling in response to obstruction and hence pressure-overload. The objective of the present study was to characterize the material properties of the CBD of the sham group and at 3 hours, 12 hours, 2 days, 8 days and 32 days (n=5 in each group) after obstruction. The Fung's exponential strain energy function… More >

X. Edward Guo¹, Gang Bao¹

Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 87-88, 2005, DOI:10.3970/mcb.2005.002.087

Abstract This article has no abstract. More >

Ghassan S. Kassab¹

Molecular & Cellular Biomechanics, Vol.1, No.1, pp. 5-22, 2004, DOI:10.3970/mcb.2004.001.005

Abstract This article has no abstract. More >

K.J. Fischer^1,2, J.A. Bastidas³, H.J. Pfaeffle², J.D. Towers²

CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.3&4, pp. 397-404, 2003, DOI:10.3970/cmes.2003.004.397

Abstract The two bones of the forearm, the radius and the ulna, have been shown to bear different proportions of the overall forearm load at the wrist and the elbow. This biomechanical data suggests load transfer between the bones occurs through the soft tissues of the forearm. Load transfer from radius to ulna through passive soft tissues such as the interosseous ligament (IOL) has been experimentally measured. Ex vivo studies of the forearm, however, cannot account for the effect of internal loads generated by the muscles and, in some cases, external forces acting directly on the… More >

Angelo Carini¹, Riccardo Pietrabissa²

CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.3&4, pp. 345-350, 2003, DOI:10.3970/cmes.2003.004.345

Abstract This article has no abstract. More >