EUN NA1, MYOUNGWON CHOI2, INDAL PARK2, SUNYOUNG LIM3,*
BIOCELL, Vol.44, No.2, pp. 193-199, 2020, DOI:10.32604/biocell.2020.08648
Abstract We investigated the effect of black sea bream extracts on changes in pro-inflammatory and anti-inflammatory
cytokines induced by lipopolysaccharide (LPS) in murine splenocytes. The levels of pro-inflammatory cytokines
[interleukin (IL)-6, tumor necrosis factor-α (TNF-α), IL-12/IL-23(p40) and IL-17A] and anti-inflammatory cytokines
[IL-4, IL-10 and interferon-γ (IFN-γ)] were assessed. Incubation of murine splenocytes with acetone+methylene
chloride (A+M) and methanol (MeOH) extracts significantly decreased LPS-induced IL-6, IL-12/IL-23(p40) and
IL-17A productions after 6 h incubation (p < 0.05). The A+M and MeOH extracts significantly increased LPS-induced
IL-4 and IFN-γ productions at 48 and 72 h incubation (p < 0.05). Treatment with A+M extract resulted… More >
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