Taiji Adachi1,*, Yoshitaka Kameo1
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 88-88, 2019, DOI:10.32604/mcb.2019.07417
Abstract Bone adaptation by remodeling is a process to change its outer shape and internal structure to the changing mechanical environment by osteoclastic bone resorption and osteoblastic bone formation. These cellular activities are regulated by mechanosensory network of osteocytes embedded in bone matrix. An imbalance between bone resorption and formation due to low loadings or disuse results in metabolic bone disorders such as osteoporosis. Many studies have identified various signaling pathways that regulate these cellular activities; however, the physiological and pathological conditions of bone as a system remain difficult to understand because of the complexity of the signaling networks including mechano-biochemical… More >
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