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    Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide

    Jia Liu*, Ying Zhang, Shulan Sun, Guirong Zhang, Ke Jiang,§ Peixin Sun*, Ye Zhang*, Bing Yao*, Rui Sui*, Yi Chen*, Xu Guo*, Tao Tang*, Ji Shi*, Haiyang Liang*, Haozhe Piao*

    Oncology Research, Vol.27, No.4, pp. 475-486, 2019, DOI:10.3727/096504018X15270916676926

    Abstract Glioma is the most common malignant tumor of the central nervous system, and it is characterized by high relapse and fatality rates and poor prognosis. Bufalin is one of the main ingredients of Chan-su, a traditional Chinese medicine (TCM) extracted from toad venom. Previous studies revealed that bufalin exerted inhibitory effects on a variety of tumor cells. To demonstrate the inhibitory effect of bufalin on glioma cells and glioma stem-like cells (GSCs) and discuss the underlying mechanism, the proliferation of glioma cells was detected by MTT and colony formation assays following treatment with bufalin. In addition, we investigated whether bufalin… More >

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