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  • Open Access

    ARTICLE

    Human chemerin induces eryptosis at concentrations exceeding circulating levels

    MARYNA TKACHENKO1, ANATOLII ONISHCHENKO2, LILIYA TRYFONYUK3, DMYTRO BUTOV4, KATERYNA KOT5, VIKTORIIA NOVIKOVA6, LIWEI FAN5,7, VOLODYMYR PROKOPIUK2,8, YURII KOT5,*, ANTON TKACHENKO2,*

    BIOCELL, Vol.48, No.8, pp. 1197-1208, 2024, DOI:10.32604/biocell.2024.050206 - 02 August 2024

    Abstract Introduction: Human chemerin is an adipokine that regulates chemotaxis, inflammation, and glucose metabolism. In addition, accumulating evidence suggests that chemerin promotes apoptosis, autophagy, and pyroptosis. However, there are no data on its impact on eryptosis. The current study aimed to analyze the effects of human active Glu-Ser chemerin on eryptosis in vitro. Materials and Methods: Human chemerin 0-2-10-50 µg/mL was incubated for 24 h with human erythrocytes (hematocrit 0.4%) obtained from eight healthy individuals. Flow cytometry-based determination of phospholipid scrambling, reactive oxygen species (ROS) production, and intracellular Ca levels was performed. To supplement data on ROS and Ca… More >

  • Open Access

    REVIEW

    Proceedings of the International Scientific Conference “Cancer, Work & Employment”
    Paris, November 21 and 22, 2022

    P. Gérain, P. Aurouet, J. Foucaud

    Psycho-Oncologie, Vol.17, No.1, pp. 11-17, 2023, DOI:10.3166/pson-2022-0227

    Abstract This paper is an overview of the International Scientific Conference on “Cancer, Work & Employment” that was held in Paris on November 21 and 22, 2022, and organized by the French National Cancer Institute (INCa). The conference was structured around four keynote presentations and two roundtables, with renowned international speakers. The focus of this conference was to discuss the challenges of return or access to work and job retention when facing cancer, from interdisciplinary perspectives (e.g., psychology, sociology, economics). Speakers analyzed return-to-work (RTW) determinants for cancer patients, with a particular focus on specific forms of More >

  • Open Access

    ARTICLE

    The effect of natural products combination on MCF-7 cells exceeds tamoxifen therapeutic dose effects in vitro

    ZEINAB KLAAB1, AZIZA HASSAN2, JAWAHER ALBAQAMI1, FAIZAH A. ALMALKI1,*

    BIOCELL, Vol.47, No.4, pp. 891-904, 2023, DOI:10.32604/biocell.2023.026556 - 08 March 2023

    Abstract Cancer remains to be one of the most severe sicknesses globally. Cases have kept rising over the years. Breast cancer (BC), which is among the leading types of cancers and predominantly affects women, is the second leading cause of cancer mortality. Researchers have developed interventions over the years; however, the BC survival rate has not improved since the 1980s. This has created the need for novel drug interventions that would manage and treat BC more effectively. This study focused on using a combination of natural product extracts such as phytoestrogen (Ziziphus jujube) and Tannin nanoparticles (NP99)… More >

  • Open Access

    ARTICLE

    SMO Algorithm to Unravel CEED Problem using Wind and Solar

    A. Prabha1,*, G. Themozhi2, Rama Reddy Sathi3

    Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 1857-1872, 2023, DOI:10.32604/iasc.2023.027442 - 19 July 2022

    Abstract This research proposes a more advanced way to address Combined Economic Emission Dispatch (CEED) concerns. Economic Load Dispatch (ELD) and Economic Emission Dispatch (EED) have been implemented to reduce generating unit fuel costs and emissions. When both economics and emission targets are taken into account, the dispatch of an aggregate cost-effective emission challenge emerges. This research affords a mathematical modeling-based analytical technique for solving economic, emission, and collaborative economic and emission dispatch problems with only one goal. This study takes into account both the fuel cost target and the environmental impact of emissions. This bi-intention… More >

  • Open Access

    ARTICLE

    Greedy-Genetic Algorithm Based Video Data Scheduling Over 5G Networks

    E. Elamaran1,*, B. Sudhakar2

    Intelligent Automation & Soft Computing, Vol.32, No.3, pp. 1467-1477, 2022, DOI:10.32604/iasc.2022.020625 - 09 December 2021

    Abstract Essential components in wireless systems are schedulin and resource allocation. The problems in scheduling refers to inactive users in a given time slot and in terms of resource allocation it refers to the issues in the allocation of physical layer resources such as power and bandwidth among the active users. In the Long Time Evolution (LTE) downlink scheduling the optimized problem refers to the flow deadlines that incorporate the formulation in the surveyed scheduling algorithm for achieving enhanced performance levels. The major challenges appear in the areas of quality and bandwidth constrains in the video… More >

  • Open Access

    ARTICLE

    Exceeding the maximum recommended dose of onabotulinumtoxinA in urologic patients

    Bristol B. Whiles1, Joshua Caldwell2, Priya Padmanabhan3

    Canadian Journal of Urology, Vol.28, No.3, pp. 10725-10728, 2021

    Abstract Introduction: Although onabotulinumtoxinA (BTX) is commonly utilized by multiple specialists, it is unclear how often or for what reasons patients receive more than the recommended maximum dose. The goal of this study was to determine if excess BTX use occurs in urologic practice.
    Materials and methods: This retrospective cohort identified patients who underwent intravesical BTX between 01/2013 and 12/2017 at an academic hospital. All BTX administrations for any indication were identified. Excess BTX was defined as receiving greater than the current recommended maximum dosage of 400 units within 3 months.
    Results: A total of 361 patients received intravesical… More >

  • Open Access

    INTRODUCTION

    Proceedings of the International PDA Symposium

    Douglas S. Moodie1, Shyam Sathanandam2, Athar M. Qureshi3

    Congenital Heart Disease, Vol.14, No.1, pp. 5-5, 2019, DOI:10.1111/chd.12761

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    “Frontiers in Fontan failure: A summary of conference proceedings”

    Camden Hebson1,2, Wendy Book1, Robert W. Elder3, Ryan Ford4, Maan Jokhadar1, Kirk Kanter5, Brian Kogon5, Adrienne H. Kovacs6, Rebecca D. Levit1, Michael Lloyd1, Kevin Maher2, Preeti Reshamwala4, Fred Rodriguez III1,2, Rene Romero7, Thor Tejada1, Anne Marie Valente8, Gruschen Veldtman9, Michael McConnell1,2

    Congenital Heart Disease, Vol.12, No.1, pp. 6-16, 2017

    Abstract “Frontiers in Fontan Failure” was the title of a 2015 conference sponsored by Children’s Healthcare of Atlanta and Emory University School of Medicine. In what is hoped to be the first of many such gatherings, speakers and attendees gathered to discuss the problem of long-term clinical deterioration in these patients. Specific focuses included properly defining the problem and then discussing different treatment strategies, both medical and surgical. The health of the liver after Fontan palliation was a particular point of emphasis, as were quality of life and future directions. More >

  • Open Access

    ARTICLE

    Is retrograde intrarenal surgery for the treatment of renal stones with diameters exceeding 2 cm still a hazard?

    Guido Giusti1, Silvia Proietti1, Lorenzo G. Luciani2, Roberto Peschechera1, Antonella Giannantoni3, Gianluigi Taverna1, Giuseppe Sortino1,4, Pierpaolo Graziotti1

    Canadian Journal of Urology, Vol.21, No.2, pp. 7207-7212, 2014

    Abstract Introduction: Major kidney stones have traditionally been treated with percutaneous nephrolithotomy. However, retrograde intrarenal surgery (RIRS), which until a few years ago was considered inappropriate for this purpose, is becoming a viable, attractive alternative. The aim of the current study was to assess the efficacy and safety of RIRS combined with holmium laser lithotripsy for the treatment of stones >2 cm in diameter in a large series of patients, reporting complications according to the Clavien-Dindo classification.
    Materials and methods: By retrospective analysis, we identified a total of 162 patients who were affected by stones greater than… More >

  • Open Access

    EDITORIAL

    Renaming Low Risk Prostate Cancer: Proceed Cautiously

    Leonard G. Gomella

    Canadian Journal of Urology, Vol.19, No.1, pp. 6069-6069, 2012

    Abstract This article has no abstract. More >

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