YU ZHANG^1,2, QINGKUN WANG², YUE HAN², JUNJIE PIAO^2,*, XIUYING JIN^1,2,*

Oncology Research, Vol.33, No.8, pp. 1933-1945, 2025, DOI:10.32604/or.2025.063395 - 18 July 2025

Abstract Background: Colorectal adenocarcinoma (COAD) is one of the most common gastrointestinal malignancies. There is a pressing need to recognize reliable biomarkers that can improve diagnostic accuracy, predict prognosis, and serve as effective molecular targets. Glutathione peroxidase 4 (GPX4) is an important antioxidant protein. Evidence demonstrates that abnormal expression of GPX4 is related to cancer initiation and progression. However, the role of GPX4 in COAD remains unclear. Methods: We employed bioinformatics analysis and conducted subsequent validation of biological processes, including cell counting kit-8 assay (CCK-8), colony formation assay, reverse transcription-quantitative polymerase chain reaction (RT-qPCR), 5-ethynyl-2′-deoxyuridine assay… More >

HAOTONG SUN^1,2, HEYING WANG^1,3, XIN LI^1,2, YANJIE HAO^1,2, JUN LING^1,2, HUAN WANG^1,2, FEIMIAO WANG^1,2, FANG XU^1,2,*

BIOCELL, Vol.47, No.3, pp. 607-618, 2023, DOI:10.32604/biocell.2023.026445 - 03 January 2023

Abstract Background: Colon adenocarcinoma (COAD) is the second leading cause of cancer death worldwide thus, identification of COAD biomarkers is critical. Mitotic Arrest Deficient 2 Like 2 (MAD2L2) is a key factor in mammalian DNA damage repair and is highly expressed in many malignant tumors. This is a comprehensive study of MAD2L2 expression, its diagnostic value, prognostic analysis, potential biological function, and impact on the immune system of patients with COAD. Methods: Gene expression, clinical relevance, prognostic analysis, diagnostic value, GO/KEGG cluster analysis, data obtained from TCGA, and bioinformatics statistical analysis were performed using the R package. Immune… More >

Chein-Shan Liu ^1,2

CMES-Computer Modeling in Engineering & Sciences, Vol.17, No.2, pp. 73-94, 2007, DOI:10.3970/cmes.2007.017.073

Abstract The primary objectives of the present exposition focus on five different types of representations of the plastic equations obtained from an elastic-perfectly plastic model by employing different corotational stress rates. They are (a) an affine nonlinear system with a finite-dimensional Lie algebra, (b) a canonical linear system in the Minkowski space, (c) a non-canonical linear system in the Minkowski space, (d) the Lie-Poisson bracket formulation, and (e) a two-generator and two-bracket formulation. For the affine nonlinear system we prove that the Lie algebra of the vector fields is so(5,1), which has dimensions fifteen, and by the… More >