Yan Song^1,2,3,#, Yiting Chen^4,#, Xiaojing Li², Peng Pan², Ningfan Hu², Lanyi Wei², Yue Xiao^1,3,*, Chaogang Wei^2,*

BIOCELL, Vol.49, No.7, pp. 1207-1223, 2025, DOI:10.32604/biocell.2025.065658 - 25 July 2025

Abstract Objectives: Progression to castration-resistant prostate cancer (CRPC) and metastasis are the greatest challenges to effective treatment. Anticancer strategies targeting the key kinases associated with the development of CRPC may represent a breakthrough. The tyrosine kinase receptor Erythropoietin-producing hepatocellular (Eph) A2 receptor is highly expressed in CRPC cell lines and may be associated with tumor invasion and metastasis. However, the effects and exact mechanisms of EphA2 in CRPC are only partially understood. This study aimed to investigate the impact of EphA2 on CRPC cell behaviors and underlying molecular pathways Methods: CRISPR/Cas9-mediated gene editing induced EphA2-disrupted in… More >

Mehdi Hassan^1,2, Safdar Ali³, Jin Young Kim^2,*, Muhammad Sanaullah⁴, Hani Alquhayz⁵, Khushbakht Safdar⁶

CMC-Computers, Materials & Continua, Vol.76, No.2, pp. 1643-1663, 2023, DOI:10.32604/cmc.2023.038578 - 30 August 2023

Abstract Breast cancer resistance protein (BCRP) is an important resistance protein that significantly impacts anticancer drug discovery, treatment, and rehabilitation. Early identification of BCRP substrates is quite a challenging task. This study aims to predict early substrate structure, which can help to optimize anticancer drug development and clinical diagnosis. For this study, a novel intelligent approach-based methodology is developed by modifying the ResNet101 model using transfer learning (TL) for automatic deep feature (DF) extraction followed by classification with linear discriminant analysis algorithm (TLRNDF-LDA). This study utilized structural fingerprints, which are exploited by DF contrary to conventional More >

Hassan Rabiei¹, Masoud Kaveh², Mohammad Reza Mosavi¹, Diego Martín^3,*

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 4831-4845, 2023, DOI:10.32604/cmc.2023.034981 - 28 December 2022

Abstract With the expanding use of the Internet of Things (IoT) devices and the connection of humans and devices to the Internet, the need to provide security in this field is constantly growing. The conventional cryptographic solutions need the IoT device to store secret keys in its non-volatile memory (NVM) leading the system to be vulnerable to physical attacks. In addition, they are not appropriate for IoT applications due to their complex calculations. Thus, physically unclonable functions (PUFs) have been introduced to simultaneously address these issues. PUFs are lightweight and easy-to-access hardware security primitives which employ… More >

V. V. Nijil^*, P. Selvan

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 1043-1062, 2023, DOI:10.32604/iasc.2023.028028 - 29 September 2022

Abstract Alternating Current–Direct Current (AC–DC) converters require a high value bulk capacitor or a filter capacitor between the DC–DC conversion stages, which in turn causes many problems in the design of a AC–DC converter. The component package size for this capacitor is large due to its high voltage rating and capacitance value. In addition, the high charging current creates more problems during the product compliance testing phase. The shelf life of these specific high value capacitors is less than that of Multilayer Ceramic Capacitors (MLCC), which limits its use for the highly reliable applications. This paper presents… More >

DILIXIATI JINSIHAN, DAN LI, MINGSHUAI ZHANG, JINCHUN FENG, QIAN ZHAO^*

BIOCELL, Vol.45, No.3, pp. 671-684, 2021, DOI:10.32604/biocell.2021.012519 - 03 March 2021

Abstract Hypoxia affects the advancement, metastasis, and metabolism of breast cancer (BC). The circular RNA ribonuclease P RNA component H1 (circRPPH1) (has_circ_0000515) is implicated in tumor progression. Nevertheless, the regulatory mechanism related to circRPPH1 in hypoxia-mediated triple-negative breast cancer (TNBC) progression is indistinct. The expression levels of circRPPH1, miR-1296-5p, tripartite motif-containing 14 (TRIM14) mRNA in tissue samples and cells were examined through quantitative real-time polymerase chain reaction (qRT-PCR). Cell viability, migration, and invasion were determined with Cell Counting Kit-8 (CCK-8) or transwell assays. The levels of glucose consumption and lactate production were assessed via the Glucose… More >

Tahir Abbas Khan¹, Sagheer Abbas¹, Allah Ditta², Muhammad Adnan Khan^{3, *}, Hani Alquhayz⁴, Areej Fatima³, Muhammad Farhan Khan⁵

CMC-Computers, Materials & Continua, Vol.65, No.3, pp. 2591-2605, 2020, DOI:10.32604/cmc.2020.011892 - 16 September 2020

Abstract The prediction of human diseases, particularly COVID-19, is an extremely challenging task not only for medical experts but also for the technologists supporting them in diagnosis and treatment. To deal with the prediction and diagnosis of COVID-19, we propose an Internet of Medical Things-based Smart Monitoring Hierarchical Mamdani Fuzzy Inference System (IoMTSM-HMFIS). The proposed system determines the various factors like fever, cough, complete blood count, respiratory rate, Ct-chest, Erythrocyte sedimentation rate and C-reactive protein, family history, and antibody detection (lgG) that are directly involved in COVID-19. The expert system has two input variables in layer… More >

Leonard G. Gomella

Canadian Journal of Urology, Vol.25, No.2, pp. 9220-9220, 2018

Abstract This article has no abstract. More >

Yuding Wang, Shawn Dason, Bobby Shayegan

Canadian Journal of Urology, Vol.23, No.4, pp. 8388-8394, 2016

Abstract Abiraterone acetate (AA) is a selective irreversible inhibitor of CYP 17, a key enzyme in androgen biosynthesis. The efficacy and safety of AA in improving survival and quality of life in metastatic castration resistant prostate cancer (mCRPC) has been demonstrated in two landmark clinical trials (COU-AA-301 and COU-AA-302). This article will review the rationale, pharmacology, clinical indications and contraindications, administration, and adverse effects of AA administration in mCRPC. More >

Rohini K. Hernandez¹, Karynsa Cetin¹, Melissa Pirolli², Jane Quigley², David Quach², Paul Smith³, Scott Stryker¹, Alexander Liede¹

Canadian Journal of Urology, Vol.22, No.4, pp. 7858-7864, 2015

Abstract Introduction: Canadian guidelines define castration-resistant prostate cancer (CRPC) at high risk of developing metastases using PSA doubling time (PSADT) <8 months, whereby men may be offered more frequent bone scans/imaging. We evaluated PSA data from nonmetastatic (M0) prostate cancer patients treated at urology and oncology clinics across the United States (US) to describe the proportion and characteristics of patients who met CRPC and high-risk criteria.
Materials and methods: We identified M0 prostate cancer patients aged ≥18 years receiving androgen deprivation therapy (ADT) in 2011 from electronic health records (EHR), covering 129 urology and 64 oncology practices across… More >

Gregory R. Thoreson, Bishoy A. Gayed, Paul H. Chung, Ganesh V. Raj

Canadian Journal of Urology, Vol.21, Suppl.2, pp. 98-105, 2014

Abstract instruction: Introduction: Prostate cancer continues to be the second leading cause of cancer-related mortality in men within the United States. Despite a consistent decline in prostate cancer mortality over the past two decades, the prognosis for men with metastatic prostate cancer remains poor with no curative therapies. In this article, we review the recently approved and emerging therapeutics for patients with castration-resistant prostate cancer.
instruction: Materials and methods: An advanced search was conducted on the ClinicalTrials.gov database, using search terms "metastatic prostate cancer", and limiting results to phase II-IV clinical trials. Clinically relevant emerging therapeutics were selected… More >