Yuriy Mayasin¹, Maria Osinnikova¹, Daria Osadchaya¹, Victoria Dmitrienko¹, Anna Gorodilova¹, Chulpan Kharisova¹, Kristina Kitaeva¹, Ivan Filin¹, Valeria Solovyeva¹, Albert Rizvanov^1,2,*

Oncology Research, Vol.33, No.9, pp. 2221-2242, 2025, DOI:10.32604/or.2025.064677 - 28 August 2025

Abstract Melanoma is a malignant neoplasm with a high propensity to metastasize, arising from melanocytes and contributing significantly to global morbidity and mortality. Despite the demonstrated efficacy of many immunotherapy approaches, these methods rely on direct destruction of tumor cells with minimal impact on the aggregate of nearby non-tumor cells, the extracellular matrix, and blood vessels that form the tumor microenvironment (TME). The TME is known to be heterogeneous and dynamic, exerting both antitumor and pro-tumor effects depending on the specific features and stage of carcinogenesis. TME has been shown in several studies to promote… More >

Wenju Wang¹, Zehua Gu^1,*, Bang Tang¹, Sen Wang², Jianfei Hao²

CMC-Computers, Materials & Continua, Vol.82, No.2, pp. 2389-2414, 2025, DOI:10.32604/cmc.2024.057392 - 17 February 2025

Abstract Current spatio-temporal action detection methods lack sufficient capabilities in extracting and comprehending spatio-temporal information. This paper introduces an end-to-end Adaptive Cross-Scale Fusion Encoder-Decoder (ACSF-ED) network to predict the action and locate the object efficiently. In the Adaptive Cross-Scale Fusion Spatio-Temporal Encoder (ACSF ST-Encoder), the Asymptotic Cross-scale Feature-fusion Module (ACCFM) is designed to address the issue of information degradation caused by the propagation of high-level semantic information, thereby extracting high-quality multi-scale features to provide superior features for subsequent spatio-temporal information modeling. Within the Shared-Head Decoder structure, a shared classification and regression detection head is constructed. A More >

Ahmed Alhussen¹, Arshiya S. Ansari^2,*

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 1903-1923, 2024, DOI:10.32604/cmc.2024.049260 - 15 May 2024

Abstract Traffic in today’s cities is a serious problem that increases travel times, negatively affects the environment, and drains financial resources. This study presents an Artificial Intelligence (AI) augmented Mobile Ad Hoc Networks (MANETs) based real-time prediction paradigm for urban traffic challenges. MANETs are wireless networks that are based on mobile devices and may self-organize. The distributed nature of MANETs and the power of AI approaches are leveraged in this framework to provide reliable and timely traffic congestion forecasts. This study suggests a unique Chaotic Spatial Fuzzy Polynomial Neural Network (CSFPNN) technique to assess real-time data… More >

Areej Jorban^1,2,3,4, Eitan Lunenfeld⁵, Mahmoud Huleihel^1,2,3,4,*

European Cytokine Network, Vol.34, No.4, pp. 54-62, 2023, DOI:10.1684/ ecn.2023.0490

Abstract Spermatogenesis is the complicated process of sperm generation. During this process, spermatogonial cells proliferate and differentiate via meiotic and post-meiotic stages to produce mature sperm. This process is under the regulation of testicular autocrine/paracrine factors. In addition, endocrine factors are crucial to complete spermatogenesis. We aimed to localize granulocyte-macrophage colony-stimulating factor (GM-CSF) and its receptor (GM-CSFR) in testicular cells and further evaluate its involvement in the development of spermatogenesis in vitro. We isolated cells from seminiferous tubule cells of seven-day-old mice and cultured them in vitro using a methylcellulose culture system (MCS), in the presence of GM-CSF… More >

Devon M. Langston¹, Daniel Evans², Stanley Moore³, Jolie Shen³, Ziho Lee⁴, Jonathan Wingate⁴, Alexander J. Skokan⁴, Aron Liaw⁵, Judith C. Hagedorn³, Benjamin N. Breyer⁵, Nima Baradaran²

Canadian Journal of Urology, Vol.30, No.2, pp. 11487-11494, 2023

Abstract Introduction: Fournier’s gangrene (FG), is a progressive, necrotizing soft tissue infection of the external genitalia, perineum, and/or anorectal region. How treatment and recovery from FG impacts quality of life related to sexual and general health is poorly characterized. Our purpose is to evaluate the long term impact of FG on overall and sexual quality of life using standardized questionnaires through a multi-institutional observational study.
Materials and methods: Multi-institutional retrospective data were collected by standardized questionnaires on patient-reported outcome measures including the Changes in Sexual Functioning Questionnaire (CSFQ) and the Veterans RAND 36 (VR-36) survey of general health-related… More >

F. Farsi, E. Huyghe, L. Vanlemmens, S. Dolbeault, T. Almont, E. Marx, I. Flandrin, J. Véronique-Baudin, B. Panes-Ruedin, P. Bondil

Psycho-Oncologie, Vol.17, No.2, pp. 99-104, 2023, DOI:10.3166/pson-2022-0235

Abstract L’abord systématisé et en routine de la préservation de la vie intime, de la sexualité et de la fertilité n’est pas encore pleinement intégré à la consultation des praticiens et pas de manière significative par les autres intervenants du parcours de soins en cancérologie. On sait pourtant, et de manière de plus en plus documentée, que ce sont des sujets de préoccupation pour les patients et leurs partenaires, qui considèrent, pour leur grande majorité, que leur santé sexuelle et/ou leurs projets parentaux sont des sujets importants. Depuis maintenant plus de dix ans, un groupe d’experts… More >

Soobia Saeed^1,*, Afnizanfaizal Abdullah¹, N. Z. Jhanjhi², Mehmood Naqvi³, Mehedi Masud⁴, Mohammed A. AlZain⁵

CMC-Computers, Materials & Continua, Vol.72, No.1, pp. 851-869, 2022, DOI:10.32604/cmc.2022.024085 - 24 February 2022

Abstract Diagnosing data or object detection in medical images is one of the important parts of image segmentation especially those data which is less effective to identify in MRI such as low-grade tumors or cerebral spinal fluid (CSF) leaks in the brain. The aim of the study is to address the problems associated with detecting the low-grade tumor and CSF in brain is difficult in magnetic resonance imaging (MRI) images and another problem also relates to efficiency and less execution time for segmentation of medical images. For tumor and CSF segmentation using trained light field database… More >

Ali Ariafar^1,2,a, Mohammadrasul Zareinejad^3,4,a, Mohammadreza Soltani¹, Yasmin Vahidi³, Zahra Faghih³

European Cytokine Network, Vol.32, No.1, pp. 1-7, 2021, DOI:10.1684/ecn.2021.0462

Abstract Background: Bladder cancer (BC) is the tenth common cancer worldwide. Despite progress in treatment and the use of chemotherapeutic drugs, the survival rate of BC patients is still low. Manipulation of the immune system was recently introduced as an interesting alternative treatment for this immunogenic cancer with fewer side effects. Accordingly, in the present study, we assessed the frequency of GM-CSF-producing lymphocytes in tumor-draining lymph nodes (TDLNs) of BC patients and evaluated their relationship with clinicopathological factors and survival rate. Methods: Fifty-four patients with BC who had received no treatment were recruited. Mononuclear cells were… More >

Weifeng Ren^1,2,#, Xiaomeng Cai^2,3,#, Jun Chen^2,3,#, Lifo Ruan^2,3, Huiru Lu², Jiayu Zhang^2,3, Yi Hu^2,3,*, Jimin Gao^1,*

Oncologie, Vol.23, No.3, pp. 359-371, 2021, DOI:10.32604/Oncologie.2021.018605 - 26 September 2021

Abstract This study reported the construction of GM-CSF-loaded chitosan/graphene oxide nanoparticles for photothermal therapy-assisted immunotherapy against murine orthotopic bladder cancer. The encapsulated GM-CSF in chitosan/graphene oxide nanoparticles facilitated their immobilization on biotinylated mouse orthotopic bladder cancer surface, resulting in slow release of antitumor immune adjuvant. Locally released GM-CSF efficiently recruited dendritic cells to bladder tumor sites, thereby promoting immune responses in mice. Thus, the activated immune response in mice provided enhanced antitumor effects. Meanwhile, the thermal effect from the nanoparticles upon light irradiation induced a significant increase in dendritic cells and T cells compared with other More >

Zhentao Wang^1,*, Kai Dong, Shuiqing Zhan

FDMP-Fluid Dynamics & Materials Processing, Vol.13, No.4, pp. 221-234, 2017, DOI:10.3970/fdmp.2017.013.221

Abstract We have investigated the unsteady internal flow occurring in an evaporating droplet interacting with a high-temperature atmospheric environment. The Navier-Stokes equations for both the liquid and the gas phases have been solved numerically in the framework of a Volume of Fluid (VOF) method relying on the so-called Continuum Surface Force (CSF) model. A specific kernel able to account for evaporation and related phase change has been incorporated directly in the VOF approach. The temperature distributions within the droplet has been found to be relatively uniform by virtue of the Marangoni flow. The transient evolution of More >