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  • Open Access

    ARTICLE

    Nicotinic acid induces apoptosis of glioma cells via the calcium-dependent endoplasmic reticulum stress pathway

    XIANGCAI YANG1, JIAGUI QU2, JIEJING LI1,*

    BIOCELL, Vol.46, No.4, pp. 1041-1051, 2022, DOI:10.32604/biocell.2022.017383

    Abstract Malignant glioma is one of the most common and deadly tumors in the central nervous system while developing effective treatments for this devastating disease remains a challenge. Previously, we demonstrated that the vitamin nicotinic acid (NA) inhibits glioma invasion. Here, we show that high-dose NA induces apoptosis of malignant glioma cells in vitro and in vivo. In cultured U251 glioma cells treated with NA, we detected ER stress that was likely caused by elevated intracellular calcium levels. The elevated calcium can be attributed to the activation of TRPV1, a cation channel that has been implicated in cutaneous More >

  • Open Access

    ARTICLE

    Calcium supplementation in colorectal cancer prevention: A systematic meta-analysis of adverse events

    XUE MEI LUO1, SHAHANAVAJ KHAN2,3,4,*, ABDUL MALIK2, FAHAD M. ALDAKHEEL5, ANIS AHMAD CHAUDHARY6, SHOUKI BAZARBASHI7, FATEMEH TABATABAIE8

    BIOCELL, Vol.46, No.3, pp. 759-767, 2022, DOI:10.32604/biocell.2022.016586

    Abstract Despite the multiple systematic reviews and meta-analyses accumulating evidence on the preventive effect of calcium supplementation for colorectal cancer, most of the associated adverse effects are not systematically analyzed. The aim of the study is evaluating adverse events associated with calcium supplementation for colorectal cancer prevention through a systematic meta-analysis. We searched Medline, PubMed Central, EMBASE (Excerpta Medica database), Scopus, Cochrane Central Register of Controlled Trials, and Web of Science published in English from database inception up to 31 July 2019. In the current systematic meta-analysis, we included human studies (including cohort studies, clinical trials,… More >

  • Open Access

    ARTICLE

    Production of Bio-Calcium Oxide Derived from Hatchery Eggshell Waste Using an Industrial-Scale Car Bottom Furnace

    Ajchara Imkum Putkham1, Suwanan Chuakham2, Yuwadee Chaiyachet2, Tanapon Suwansopa2, Apipong Putkham2,*

    Journal of Renewable Materials, Vol.10, No.4, pp. 1137-1151, 2022, DOI:10.32604/jrm.2022.018560

    Abstract The valorization of eggshell waste as bio-calcium oxide is crucial for pollution prevention and supporting sustainable development. There are several reports on the thermal conversion of eggshell waste to calcium oxide for the partial or complete substitution of natural lime applications. However, this paper reports the thermal decomposition of large amounts of hatchery eggshell waste on an industrial-scale car bottom furnace for the first time. The hatchery eggshell waste was sundried and placed into five stacked trays in the car bottom furnace. The calcination of the eggshell waste was conducted at 900°C for 3 and… More > Graphic Abstract

    Production of Bio-Calcium Oxide Derived from Hatchery Eggshell Waste Using an Industrial-Scale Car Bottom Furnace

  • Open Access

    ARTICLE

    Calcium chloride linked camel milk derived casein nanoparticles for the delivery of sorafenib in hepatocarcinoma cells

    AASTHA MITTAL1, NEELAM MAHALA1, KOWTHAVARAPU VENKATA KRISHNA2, UMA S. DUBEY1,*, SUNIL KUMAR DUBEY2,3,*

    BIOCELL, Vol.46, No.1, pp. 127-136, 2022, DOI:10.32604/biocell.2021.015932

    Abstract Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma, is limited by its low oral bioavailability. To overcome this drawback, we have developed novel camel milk casein-derived nanoparticles as a drug delivery system. Camel milk casein is not only biocompatible on oral administration but is actually a dietary protein of pharmaceutical relevance. Casein is used because of its amphiphilic nature, self-assembling property, ability to show sustained release, and capability of encapsulating both hydrophilic and hydrophobic drugs. In this study, camel milk casein nanoparticles loaded with sorafenib were developed and characterized. Characterization of casein… More >

  • Open Access

    ARTICLE

    Identification of key pathways and gene expression in the activation of mast cells via calcium flux using bioinformatics analysis

    XIAOYU WANG1,2,#,*, TAKESHI YAMAMOTO2,#, MAKOTO KADOWAKI2, YIFU YANG1

    BIOCELL, Vol.45, No.2, pp. 395-415, 2021, DOI:10.32604/biocell.2021.012280

    Abstract Mast cells are the main effector cells in IgE-associated allergic disorders, and we have reported that mucosal mast cells (MMCs) play a more important role in the development of food allergy (FA). IgE with antigen or calcium ionophore stimulation can lead to the activation of MMCs via a calcium-dependent pathway. The purpose of the present study was to identify gene signatures with IgE/antigen (dinitrophenyl-bovine serum albumin, DNP-BSA) or calcium ionophore (A23187) on the activation of MMCs. Differentially expressed genes between the two types of samples were identified with microarray analysis. Gene ontology functional and pathway… More >

  • Open Access

    ARTICLE

    Sentinel-2 Satellite Imagery Application to Monitor Soil Salinity and Calcium Carbonate Contents in Agricultural Fields

    Ahmed M. Zeyada1,*, Khalid A. Al-Gaadi1,2, ElKamil Tola2, Rangaswamy Madugundu2, Ahmed A. Alameen2

    Phyton-International Journal of Experimental Botany, Vol.92, No.5, pp. 1603-1620, 2023, DOI:10.32604/phyton.2023.027267

    Abstract The estuary tides affect groundwater dynamics; these areas are susceptible to waterlogging and salinity issues. A study was conducted on two fields with a total area of 60 hectares under a center pivot irrigation system that works with solar energy and belong to a commercial farm located in Northern Sudan. To monitor soil salinity and calcium carbonate in the area and stop future degradation of soil resources, easy, non-intrusive, and practical procedures are required. The objective of this study was to use remote sensing-determined Sentinel-2 satellite imagery using various soil indices to develop prediction models… More >

  • Open Access

    ARTICLE

    Bifid T waves on the ECG and genetic variation in calcium channel voltage‐dependent beta 2 subunit gene (CACNB2) in acute Kawasaki disease

    Jun Oyamada1, Chisato Shimizu1, Jihoon Kim2, Matthew R. Williams1,3, Eileen Png4, Martin L. Hibberd4, Adriana H. Tremoulet1,3, James C. Perry1,3, Jane C. Burns1,3

    Congenital Heart Disease, Vol.14, No.2, pp. 213-220, 2019, DOI:10.1111/chd.12696

    Abstract Background: We previously described the association of genetic variants in calcium channel genes and susceptibility to Kawasaki disease (KD), an acute, self‐limited vas‐ culitis, and the most common cause of acquired cardiac disease in children. Abnormal repolarization of cardiomyocytes and changes in T wave morphology have been re‐ ported in KD but have not been studied systematically.
    Methods: We analyzed acute and convalescent ECG T wave morphology in two inde‐ pendent cohorts of KD subjects and studied the association between bifid T waves and genetic variants in previously reported genes with SNVs associated with cardiac repolarization.
    Results: Bifid… More >

  • Open Access

    ARTICLE

    Cryopreservation of Cyrtopodium hatschbachii Pabst (Orchidaceae) immature seeds by encapsulation-dehydration

    MAURO RODRIGO SURENCISKI*, EDUARDO ALBERTO FLACHSLAND, GRACIELA TERADA, LUIS AMADO MROGINSKI, HEBE YOLANDA REY

    BIOCELL, Vol.36, No.1, pp. 31-36, 2012, DOI:10.32604/biocell.2012.36.031

    Abstract The aim of the present study was to investigate the efficiency of the encapsulation-dehydration technique for cryopreservation of Cyrtopodium hastchbachii Pabst seeds. Immature seeds of this species were cryopreserved by an encapsulation-dehydration technique. Seeds of five immature pods, 120 days after pollination, were encapsulated in 3% calcium alginate matrix and pretreated in liquid medium supplemented with 0.08 M sucrose (24 h), 0.15 M sucrose (24 h), 0.25 M sucrose (48 h), 0.5 M sucrose (24 h) and 0.75 M sucrose (24 h) in shaker at 60 rpm. Alginate beads were dehydrated 5 h in silicagel and More >

  • Open Access

    ARTICLE

    Hyperhydricity control of in vitro shoots of Turbinicarpus valdezianus (Möller) GL & F

    García Osuna HT, A Benavides Mendoza, L Escobedo Bocardo, JA Villarreal Quintanilla, E Cornejo Oviedo

    Phyton-International Journal of Experimental Botany, Vol.80, pp. 175-179, 2011, DOI:10.32604/phyton.2011.80.175

    Abstract Turbinicarpus valdezianus is a species under special protection, according to the current law NOM-059-ECOL-2010. It spreads preferably through shoot proliferation in vitro. A common problem associated with the propagation of this species by tissue culture is the hyperhydricity or excess of water accumulation in the tissues of shoots explants. The literature on this topic indicates that such response is related with oxidative stress. Because of this, the effects of inhibitors of the gibberellins [paclobutrazol (PBZ) and calcium prohexadione (PCa)] and salicylic (SA) and benzoic acids (BA) were tested to diminish the hiperhydrycity of the sprouts, which was… More >

  • Open Access

    ARTICLE

    Effect of Prohexadione calcium, 6-benzyl amino purine and 6-furfuryladenine on vegetative growth and fruit quality in apple

    Ramírez H1, JC Sánchez-Canseco1, VM Zamora-Villa2, JH Rancaño-Arrioja3

    Phyton-International Journal of Experimental Botany, Vol.86, pp. 282-289, 2017, DOI:10.32604/phyton.2017.86.282

    Abstract It is well established that the climatic change is altering yield in fruit trees. This adversity reflects, among others, extreme temperature modifications in northern Mexico. This effect modifies negatively the physiology of apple trees (Malus domestica Borkh.), originating excessive shoot growth and a decrease in flower bud formation. In this study, Prohexadione-Ca (P-Ca), 6-benzyl amino purine (BAP) and N6-furfuryladenine (kinetin) were evaluated on shoot and reproductive growth in Golden Delicious apple trees in Arteaga Coah., Mexico. A completely randomized design with 12 treatments was used. These were: Control, Prohexadione calcium (Ca-P) at doses of 150, 300… More >

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