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  • Open Access


    Clinical Significance of CA-199 and LINC01197 in Pancreatic Cancer

    Dan Zhang1, Shengyong Fu2,*, Jie Xu3, Xia Sun1

    Oncologie, Vol.22, No.2, pp. 95-105, 2020, DOI:10.32604/oncologie.2020.012439

    Abstract This study aimed to explore the expression and clinical significance of LINC01197 in the serum of patients with pancreatic cancer (PC). Methods: A total of 50 PC patients (patient group) treated in our hospital from March 2012 to April 2014 were collected, and another 50 healthy people (normal group) were collected for physical examination. The expression of LINC01197 in the serum of the two groups was detected by qRT-PCR method, and the expression of CA-199 in serum was detected by Roche automatic biochemistry. The expression and diagnostic values of CA-199 and LINC01197 in PC were analyzed, and the relationship between… More >

  • Open Access


    Expression and Clinical Significance of miR-152 and CYFRA21-1 in Ovarian Cancer Tissues

    Guiping Chen*, Tiantian Xie, Haibo Chen, Lijuan Chen

    Oncologie, Vol.22, No.2, pp. 83-93, 2020, DOI:10.32604/oncologie.2020.012491

    Abstract To investigate the expression and clinical significance of miR-152 and CYFRA21-1 in ovarian cancer (OC) tissues. Seventy-four OC patients diagnosed in our hospital from March 2016 to April 2019 (research group, RG) and 30 patients with benign ovarian tumor at the same time (control group, CG) were collected as research objects in this experiment. qRT-PCR and ELISA were used to detect and observe the expression levels of miR-152 in patient tissues and CYFRA21-1 in serum. ROC curves were drawn to analyze the diagnostic value of miR-152 and CYFRA21-1 in OC. The clinicopathological correlation analysis was observed, Pearson was used to… More >

  • Open Access


    Diagnosis of Lung Cancer Based on Plasma Metabolomics Combined with Serum Markers

    Dong Zhang1,#, Lingxia Tong2,#, Qingjun Wang1, Yunfeng Cao3, Yu Gao1, Donghua Yang1, Tianhao Bao4,5, Zhitu Zhu1,*

    Oncologie, Vol.22, No.2, pp. 75-82, 2020, DOI:10.32604/oncologie.2020.012376

    Abstract Predicting the onset and metastasis of early tumor is the primary means of improving lung cancer prognosis. The purpose of this study was to identify the ability of plasma metabolomics combined with blood markers to establish benign lung disease versus lung cancer regression models. Blood samples were collected from 174 lung cancer patients, 350 benign lung disease patients and 100 healthy volunteers and the metabolites were analyzed by mass spectrometry. The target metabolites consisted of 23 amino acids, 26 acylcarnitines and 45 conventional blood markers. A regression analysis model was established based on 12 metabolites and five blood markers selected… More >

  • Open Access


    The Relationship BRCA1/2 Genes and Family History in Ovarian Cancers

    Neslihan Duzkale1,*, Hikmet Taner Teker2

    Oncologie, Vol.22, No.2, pp. 65-74, 2020, DOI:10.32604/oncologie.2020.013707

    Abstract BRCA1/2 genes are responsible for the hereditary breast and ovarian cancer syndrome. In this study, Turkish women with ovarian cancer were investigated in terms of demographic, clinicopathologic and family cancer stories according to their condition of the BRCA1/2 genes mutation carrier. During 2011 to 2017 in Turkey, BRCA1 and BRCA2 genes were analyzed in 38 women, who were diagnosed with cancer using Next Generation Sequencing technique. Pathogenic mutations were detected in 9 (23.7%) of patients. The diagnosis age for Ovarian cancer patients for BRCA1/2 mutation carriers was found higher. It was seen that mutations mostly occurred in the BRCA2 gene… More >

  • Open Access


    A Narrative Review: Classification of Pap Smear Cell Image for Cervical Cancer Diagnosis

    Wan Azani Mustafa1,*, Afiqah Halim1, Khairul Shakir Ab Rahman2

    Oncologie, Vol.22, No.2, pp. 53-63, 2020, DOI:10.32604/oncologie.2020.013660

    Abstract Cervical cancer develops as cells transformation in the cervix of a female that connects the uterus to the vagina. This cancer may impact the columnal epithelial cells of the cervix and therefore can be expanded to the lymphatic and circulatory system (metastasize), sometimes the kidneys, liver, prostate, vagina, and rectum. Many of the cervical cancer patients survived by taking early prevention by undergoing a Pap Smear Test. However, the result of the test usually takes a few weeks which is extremely time-consuming especially at the government hospital. The purpose of this research was to study the detection and classification method… More >

  • Open Access


    Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors

    Chuanwei Xu1, Renju Ding2, Chuanping Xu3,*

    Oncologie, Vol.22, No.1, pp. 43-51, 2020, DOI:10.32604/oncologie.2020.012445

    Abstract To analyze the effects of different surgical procedures for the treatment of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight patients with differentiated thyroid cancer were selected and grouped as control group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group (OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL- 2R expression levels; the incidence of complications; and the differentiated thyroid carcinoma (DTC) relapse rate were compared between the two groups. The serum IL-17 and SIL-2R levels were lower in the OG than… More >

  • Open Access


    Effects of Dexmedetomidine Combined with Remifentanil Anesthesia and Propofol Combined with Remifentanil Anesthesia on Perioperative Inflammatory Response and Pulmonary Function in Patients with Lung Cancer

    Siqiang Tian1,#, Yao Jiang2,#, Ying Wang1, Jie Song1,*

    Oncologie, Vol.22, No.1, pp. 13-21, 2020, DOI:10.32604/oncologie.2020.012492

    Abstract To explore the effects of dexmedetomidine combined with remifentanil anesthesia and propofol combined with remifentanil anesthesia on perioperative inflammatory response and pulmonary function in patients with lung cancer. Totally 128 patients admitted to our hospital for lung cancer surgery were taken as the research object of this experiment. Among them, 67 cases were sedated with dexmedetomidine combined with remifentanil (Group A), and 61 cases were sedated with propofol combined with remifentanil (Group B). The changes of vital signs, respiratory interval (RR), blood oxygen saturation (SpO2) and blood sugar before and after sedation were recorded. The changes of inflammatory factors TNF-α,… More >

  • Open Access


    Generalized Model of Blood Flow in a Vertical Tube with Suspension of Gold Nanomaterials: Applications in the Cancer Therapy

    Anees Imtiaz1, Oi-Mean Foong2, Aamina Aamina1, Nabeel Khan1, Farhad Ali3, 4, *, Ilyas Khan5

    CMC-Computers, Materials & Continua, Vol.65, No.1, pp. 171-192, 2020, DOI:10.32604/cmc.2020.011397

    Abstract Gold metallic nanoparticles are generally used within a lab as a tracer, to uncover on the presence of specific proteins or DNA in a sample, as well as for the recognition of various antibiotics. They are bio companionable and have properties to carry thermal energy to tumor cells by utilizing different clinical approaches. As the cancer cells are very smaller so for the infiltration, the properly sized nanoparticles have been injected in the blood. For this reason, gold nanoparticles are very effective. Keeping in mind the above applications, in the present work a generalized model of blood flow containing gold… More >

  • Open Access


    Genetically Encoded FRET Biosensor Detects the Enzymatic Activity of Prostate-Specific Antigen

    Hui Yao1, Liqun Wang3, Jia Guo1, Weimin Liu4, Jingjing Li1, Yingxiao Wang2, Linhong Deng1,*, Mingxing Ouyang1,2,3,*

    Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 101-111, 2020, DOI:10.32604/mcb.2020.09595

    Abstract Prostate cancer is the most common cancer among men beyond 50 years old, and ranked the second in mortality. The level of Prostate-specific antigen (PSA) in serum has been a routine biomarker for clinical assessment of the cancer development, which is detected mostly by antibody-based immunoassays. The proteolytic activity of PSA also has important functions. Here a genetically encoded biosensor based on fluorescence resonance energy transfer (FRET) technology was developed to measure PSA activity. In vitro assay showed that the biosensor containing a substrate peptide ‘RLSSYYSGAG’ had 400% FRET change in response to 1 µg/ml PSA within 90 min, and… More >

  • Open Access


    Association of hypoxia-inducible factor-1α (HIF1α) 1772C/T gene polymorphism with susceptibility to renal cell carcinoma/prostate cancer


    BIOCELL, Vol.44, No.2, pp. 257-262, 2020, DOI:10.32604/biocell.2020.08826

    Abstract In this study, we used a meta-analysis method to evaluate the relationship between hypoxia-inducible factor-1α (HIF1α) 1772C/T gene polymorphism (rs 11549465) and renal cell carcinoma (RCC)/prostate cancer risk. We searched for relevant studies (before March 1, 2019) on Cochrane Library, Embase, and PubMed. Studies meeting the inclusion criteria were recruited into this meta-analysis. The outcome of dichotomous data was showed in the way of odds ratios (OR), and 95% confidence intervals (CI) were also counted. In this investigation, there was no association between HIF1α 1772C/T gene polymorphism and susceptibility to RCC in Caucasians, Asians as well as overall populations. In… More >

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