D. Boinon, C. Charles, L. Fasse, J. Journiac, G. Pallubicki, E. Guerdoux-Ninot, G. Ninot, A. Couillet, J.-B. Le Provost, J. Savard, S. Dauchy

Psycho-Oncologie, Vol.16, No.1, pp. 173-181, 2022, DOI:10.3166/pson-2022-0179

Abstract Cognitive behavioral therapy for insomnia (CBTI) remains difficult to access for patients with cancer. Its digitalization seem like a promising solution to benefit as many people as possible. The feasibility of a Quebec CBTI program was thus demonstrated in France, while revealing the limits of a self-help remote program for patients with cancer. The challenge remains to better understand with the Sleep-4-All-2.0 protocol study the role of healthcare professionals in supporting patients in this type of program.

Résumé
La thérapie cognitivocomportementale de l’insomnie (TCC-I) demeure difficile d’accès pour les patients atteints de cancer. Sa digitalisation semble une solution prometteuse… More >

J. Phan, V. Laurence, P. Marec-Berard, C. Cordero, C. Riberon, C. Flahault

Psycho-Oncologie, Vol.16, No.2, pp. 243-252, 2022, DOI:10.3166/pson-2022-0197

Abstract Aims: Adolescents and Young Adults (AYAs) with cancer facing the loss of another AYA with cancer may face a “triple task”: the process of adolescence, psychological adjustment to cancer, and the bereavement process of a sick peer. The aim of this study was to explore the processes underlying the loss of a sick peer in AYAs with cancer.
Procedure: A single interview was submitted to an Interpretative Phenomenological Analysis (IPA), designed to understand the system of meanings attached to a subjective and intimate phenomenon such as bereavement.
Results: Six major themes emerge from the IPA: the life course; the care… More >

D. Gros

Psycho-Oncologie, Vol.16, No.2, pp. 260-264, 2022, DOI:10.3166/pson-2022-0192

Abstract To fulfill its function as well as possible, medical art requires considering each patient in the totality of his biological and biographical being. However, the medical world faces a model fond of standardization of practices and inclined to give primacy to the requirements of science and machines over those of humans. As health professionals, we all strive daily to preserve a harmonious alliance between science and humanity. We aspire to maintain it, but we are aware of the threats hanging over it. This awareness should encourage us to carry out an interdisciplinary reflection. A multidimensional object, infinitely overflowing the biomedical… More >

M. Laget, L. Fasse, B. Fresneau, E. Ricadat, S. Rivollet

Psycho-Oncologie, Vol.16, No.2, pp. 267-272, 2022, DOI:10.3166/pson-2022-0190

Abstract As part of the medical follow-up program for adult survivors of childhood cancer at the Institut Gustave Roussy (Villejuif, France), a psychological consultation is offered. This article is based on 198 interviews with patients between the ages of 18 and 67 who were diagnosed between the ages of 0 and 24. These meetings give voice to the subjectivity of cancer and recovery, revealing the traces of this experience afterwards. The issues at stake in the narrative activity initiated in the context of this consultation, and which may continue beyond, are approached from a metapsychological perspective.

Résumé
Dans le cadre… More >

B. Porro, A. Michel, F. Cousson-Gélie

Psycho-Oncologie, Vol.16, No.2, pp. 273-281, 2022, DOI:10.3166/pson-2022-0181

Abstract The aim is to assess the associations between social precariousness, perceived social support, and the return to work (RTW) in the first year following the beginning of adjuvant breast cancer treatment. Sixty-eight breast cancer patients encountered when starting their adjuvant treatment (T0) were followed up at 3 (T1) and 12 months (T2). Friends’ informative support at T0 favours the RTW at T1. Precariousness and negative support at T0 and T2 decrease the likelihood of RTW at T2. RTW support should be offered and tailored at the outset of treatment.

Résumé
L’objectif est d’étudier les liens entre précarité sociale, soutien… More >

OZAN CEM GULER^1,*, EZGI OYMAK², GOZDE YAZICI³, OZLEM OZKAYA AKAGUNDUZ⁴, OGUZ CETINAYAK⁵, PETEK ERPOLAT⁶, ATIL AKSOY⁷, MURSEL DUZOVA⁸, BERNA AKKUS YILDIRIM⁹, MERAL KURT¹⁰, EMINE CANYILMAZ¹¹, GULER YAVAS¹², SERAP AKYUREK¹³, DIDEM COLPAN OKSUZ¹⁴, ESRA KAYTAN SAGLAM¹⁵, OMUR KARAKOYUN CELIK¹⁶, ENIS OZYAR¹⁷, MUSTAFA CENGIZ³, CEM ONAL^1,2,12

Oncology Research, Vol.31, No.3, pp. 299-306, 2023, DOI:10.32604/or.2023.028840

Abstract The aim of this study was to examine the prognostic factors and treatment outcomes of cervical esophageal carcinoma (CEC) patients who underwent definitive chemoradiotherapy (CRT). The clinical data of 175 biopsy-confirmed CEC patients treated with definitive CRT between April 2005 and September 2021 were retrospectively analyzed. The prognostic factors predicting overall survival (OS), progression-free survival (PFS), and local recurrence-free survival (LRFS) were assessed in uni- and multivariable analyses. The median age of the entire cohort was 56 years (range: 26–87 years). All patients received definitive radiotherapy with a median total dose of 60 Gy, and 52% of the patients received… More >

YAPING GAN^1,2,#, TING LIU^3,#, WEIFENG FENG^1,#, LIANG WANG⁴, LI LI⁵, YINGXIA NING^1,*

Oncology Research, Vol.31, No.3, pp. 333-343, 2023, DOI:10.32604/or.2023.028694

Abstract Various therapeutic strategies have been developed to overcome ovarian cancer. However, the prognoses resulting from these strategies are still unclear. In the present work, we screened 54 small molecule compounds approved by the FDA to identify novel agents that could inhibit the viability of human epithelial ovarian cancer cells. Among these, we identified disulfiram (DSF), an old alcohol-abuse drug, as a potential inducer of cell death in ovarian cancer. Mechanistically, DSF treatment significantly reduced the expression of the anti-apoptosis marker B-cell lymphoma/leukemia-2 (Bcl-2) and increase the expression of the apoptotic molecules Bcl2 associated X (Bax) and cleaved caspase-3 to promote… More >

NING AN^1,#, HEQING PENG^2,#, MIN HOU³, DUOFENG SU², LIU WANG⁴, XIAOGANG SHEN^5,*, MING ZHANG^1,*

Oncology Research, Vol.31, No.3, pp. 307-316, 2023, DOI:10.32604/or.2023.028564

Abstract Zinc-finger proteins play different roles in cancer; however, the function of zinc-finger protein ZNF575 in cancer remains unclear. In the present study, we aimed to determine the function and expression of ZNF575 in colorectal cancer. Proliferation assay, colony formation assay, and tumor model in mice were used to investigate the function of ZNF575 after ectopic expression of ZNF575 in colorectal cancer (CRC) cells. RNA sequencing, ChIP, and luciferase assays were used to investigate the mechanism behind ZNF575 regulation of CRC cell growth. The expression of ZNF575 was determined by IHC staining in 150 pairs of malignant CRC tissues, followed by… More > Graphic Abstract

LAZAR S. POPOVIC^1,2,*, GORANA MATOVINA-BRKO¹, MAJA POPOVIC^1,2, KEVIN PUNIE³, ANA CVETANOVIC^4,5, MATTEO LAMBERTINI^6,7

Oncology Research, Vol.31, No.3, pp. 221-238, 2023, DOI:10.32604/or.2023.028525

Abstract Triple-negative breast cancer (TNBC) is a disease with often an aggressive course and a poor prognosis compared to other subtypes of breast cancer. TNBC accounts for approximately 10%–15% of all diagnosed breast cancer cases and represents a high unmet need in the field. Up to just a few years ago, chemotherapy was the only systemic treatment option for this subtype (1). To date, TNBC is considered a heterogeneous disease. One of the existing classifications is based on the analysis of mRNA expression in 587 TNBC cases, in which Lehman et al. proposed six subtypes of TNBC as follows: two basal-like… More > Graphic Abstract

SHUIZHONG CEN^1,#, XIAOJIE PENG^2,#, JIANWEN DENG^3,#, HAIYUN JIN⁴, ZHINAN DENG⁵, XIAOHUA LIN³, DI ZHU³, MING JIN⁶, YANWEN ZHU³, PUSHENG ZHANG³, YUNFENG LUO³, HONGYAN HUANG^3,*

Oncology Research, Vol.31, No.3, pp. 375-388, 2023, DOI:10.32604/or.2023.028256

Abstract Triple-negative breast cancer (TNBC) is characterized by fast growth, high metastasis, high invasion, and a lack of therapeutic targets. Mitosis and metastasis of TNBC cells are two important biological behaviors in TNBC malignant progression. It is well known that the long noncoding RNA AFAP1-AS1 plays a crucial role in various tumors, but whether AFAP1-AS1 is involved in the mitosis of TNBC cells remains unknown. In this study, we investigated the functional mechanism of AFAP1-AS1 in targeting Polo-like Kinase 1 (PLK1) activation and participating in mitosis of TNBC cells. We detected the expression of AFAP1-AS1 in the TNBC patient cohort and… More > Graphic Abstract