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  • Open Access

    ARTICLE

    Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

    Thean Heng Tan1, Najihah Mohd Hashim2, Wageeh Abdulhadi Yehya Dabdawb1, Mochamad Zakki Fahmi3,*, Hwei Voon Lee1,*

    Journal of Renewable Materials, Vol.12, No.1, pp. 29-43, 2024, DOI:10.32604/jrm.2023.043449

    Abstract The study focuses on the development of biocompatible and stable FA-functionalized nanocrystalline cellulose (NCC) as a potential drug delivery system for targeting folate receptor-positive cancer cells. The FA-functionalized NCCs were synthesized through a series of chemical reactions, resulting in nanoparticles with favorable properties for biomedical applications. The microstructural analysis revealed that the functionalized NCCs maintained their rod-shaped morphology and displayed hydrodynamic diameters suitable for evading the mononuclear phagocytic system while being large enough to target tumor tissues. Importantly, these nanoparticles possessed a negative surface charge, enhancing their stability and repelling potential aggregation. The binding specificity of FA-functionalized NCCs to folate… More > Graphic Abstract

    Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

  • Open Access

    ARTICLE

    Is There a Specific Profile of COVID-19 Risk Perception among People with Cancer? A Cross-Sectional Study

    Existe-t-il un profil spécifique de perception du risque de COVID-19 chez les personnes atteintes d’un cancer ? une étude transversale

    Renaud Mabire-Yon1,*, Arnaud Siméone1, Thibaud Marmorat2, Anne-Sophie Petit1, Mathilde Perray1, Costanza Puppo1, Charlotte Bauquier1, Claire Della Vecchia1, Hervé Picard3, Marie Préau1

    Psycho-Oncologie, Vol.17, No.4, pp. 245-256, 2023, DOI:10.32604/po.2023.042296

    Abstract Aims: This study aimed to determine if people with cancer (PWC) exhibit a unique COVID-19 risk perception profile and identify psychosocial factors characterizing PWC who do not conform to the majority risk perception profile. Procedure: A cross-sectional online self-questionnaire study was conducted in France from April 25 to May 07, 2020, with a sample (n = 748) comprising PWC, individuals not currently receiving cancer treatment, and those without a history of cancer. Latent profiles of COVID-19 risk perception (PCRP) were established. Methods: A multivariate multinomial logistic regression was performed to assess the association between cancer status and PCRP membership. Characteristics… More >

  • Open Access

    ORIGINAL RESEARCH

    Exploratory Study of Intolerance of Uncertainty and Its Cognitive Processes by the Stroop Task among Parents of a Childhood Cancer Survivor

    Etude exploratoire de l’intolérance à l’incertitude et de ses processus cognitifs par la tâche du Stroop chez les parents d’un enfant en rémission de cancer

    Marie Vander Haegen*, Anne-Marie Etienne

    Psycho-Oncologie, Vol.17, No.4, pp. 257-266, 2023, DOI:10.32604/po.2023.043340

    Abstract Introduction. No study has examined the relationship between the factor of intolerance of uncertainty and its effects on the cognitive processes among parents of a childhood cancer survivor. Intolerance of uncertainty is a central factor in generalized anxiety disorder; an anxiety disorder in which impaired processing of cognitive information in the form of cognitive biases is also observed. The aim of the study was to measure, via a classical Stroop test and an emotional Stroop test, the orientation of selective attention in relation to the uncertainty intolerance factor. Methods. 61 parents of a childhood cancer survivor (aged 4 to 6… More >

  • Open Access

    ARTICLE

    Evaluation of the Burnout of Caregivers of Institut de Cancérologie d’Akanda

    Evaluation du burnout du personnel soignant de l’Institut de Cancérologie d’Akanda

    A. C. Filankembo Kava*, B. C. Ndjengue Bengono, P. L. Nzamba Bissielou, C. Nziengui Tirogo, A. Kabena, T. Mpami, E. Belembaogo

    Psycho-Oncologie, Vol.17, No.4, pp. 267-273, 2023, DOI:10.32604/po.2023.044512

    Abstract Aim: Oncologists are particularly prone to developing burnout syndrome due to the demanding task of caring for cancer patients. Undiagnosed and incorrectly managed, burnout can have a negative impact on professional performance. The objective of the study is to measure the frequency of burnout among nursing staff at the Institut de Cancérologie d’Akanda (ICA) and to assess the main risk factors. Procedure: We conducted a cross-sectional study at the ICA during the month of January 2022. Burnout was assessed using the Maslach Burnout Inventory (MBI). Results: Between the 42 participants, there was a female predominance (57.1%) with a male to… More >

  • Open Access

    REVIEW

    Circular RNAs in breast cancer diagnosis, treatment and prognosis

    XIAOJIA HUANG1,#, CAILU SONG2,#, JINHUI ZHANG2, LEWEI ZHU3,*, HAILIN TANG2,*

    Oncology Research, Vol.32, No.2, pp. 241-249, 2024, DOI:10.32604/or.2023.046582

    Abstract Breast cancer has surpassed lung cancer to become the most common malignancy worldwide. The incidence rate and mortality rate of breast cancer continue to rise, which leads to a great burden on public health. Circular RNAs (circRNAs), a new class of noncoding RNAs (ncRNAs), have been recognized as important oncogenes or suppressors in regulating cancer initiation and progression. In breast cancer, circRNAs have significant roles in tumorigenesis, recurrence and multidrug resistance that are mediated by various mechanisms. Therefore, circRNAs may serve as promising targets of therapeutic strategies for breast cancer management. This study reviews the most recent studies about the… More >

  • Open Access

    ARTICLE

    NAD+ associated genes as potential biomarkers for predicting the prognosis of gastric cancer

    XIANGDONG SUN1,2,#, HUIJUAN WEN1,2,#, FAZHAN LI1,2, IHTISHAM BUKHARI1,2, FEIFEI REN1,2, XIA XUE1,2, PENGYUAN ZHENG1,2,*, YANG MI1,2,*

    Oncology Research, Vol.32, No.2, pp. 283-296, 2024, DOI:10.32604/or.2023.044618

    Abstract Nicotinamide adenine dinucleotide (NAD+) plays an essential role in cellular metabolism, mitochondrial homeostasis, inflammation, and senescence. However, the role of NAD+-regulated genes, including coding and long non-coding genes in cancer development is poorly understood. We constructed a prediction model based on the expression level of NAD+ metabolism-related genes (NMRGs). Furthermore, we validated the expression of NMRGs in gastric cancer (GC) tissues and cell lines; additionally, β-nicotinamide mononucleotide (NMN), a precursor of NAD+, was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation, cell cycle, apoptosis, and senescence-associated secretory… More > Graphic Abstract

    NAD+ associated genes as potential biomarkers for predicting the prognosis of gastric cancer

  • Open Access

    ARTICLE

    GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling

    TINGTING LI1, WEI ZHONG1, LIU YANG1, ZHIYU ZHAO1, LI WANG1, CONG LIU1, WANYUN LI1, HAIYAN LV2, SHENGYU WANG1, JIANGHUA YAN1, TING WU1,*, GANG SONG1,*, FANGHONG LUO1,*

    Oncology Research, Vol.32, No.2, pp. 361-371, 2024, DOI:10.32604/or.2023.043807

    Abstract The high mortality rate associated with gastric cancer (GC) has resulted in an urgent need to identify novel therapeutic targets for GC. This study aimed to investigate whether GAIP interacting protein, C terminus 1 (GIPC1) represents a therapeutic target and its regulating mechanism in GC. GIPC1 expression was elevated in GC tissues, liver metastasis tissues, and lymph node metastases. GIPC1 knockdown or GIPC1 blocking peptide blocked the platelet-derived growth factor receptor (PDGFR)/PI3K/AKT signaling pathway, and inhibited the proliferation and migration of GC cells. Conversely, GIPC1 overexpression markedly activated the PDGFR/PI3K/AKT signaling pathway, and promoted GC cell proliferation and migration. Furthermore,… More > Graphic Abstract

    GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling

  • Open Access

    ARTICLE

    Combinational therapy with Myc decoy oligodeoxynucleotides encapsulated in nanocarrier and X-irradiation on breast cancer cells

    BEHROOZ JOHARI1,2,#,*, MILAD PARVINZAD LEILAN1,#, MAHMOUD GHARBAVI3, YOUSEF MORTAZAVI1, ALI SHARAFI2, HAMED REZAEEJAM4

    Oncology Research, Vol.32, No.2, pp. 309-323, 2024, DOI:10.32604/or.2023.043576

    Abstract The Myc gene is the essential oncogene in triple-negative breast cancer (TNBC). This study investigates the synergistic effects of combining Myc decoy oligodeoxynucleotides-encapsulated niosomes-selenium hybrid nanocarriers with X-irradiation exposure on the MDA-MB-468 cell line. Decoy and scramble ODNs for Myc transcription factor were designed and synthesized based on promoter sequences of the Bcl2 gene. The nanocarriers were synthesized by loading Myc ODNs and selenium into chitosan (Chi-Se-DEC), which was then encapsulated in niosome-nanocarriers (NISM@Chi-Se-DEC). FT-IR, DLS, FESEM, and hemolysis tests were applied to confirm its characterization and physicochemical properties. Moreover, cellular uptake, cellular toxicity, apoptosis, cell cycle, and scratch repair… More > Graphic Abstract

    Combinational therapy with Myc decoy oligodeoxynucleotides encapsulated in nanocarrier and X-irradiation on breast cancer cells

  • Open Access

    ARTICLE

    High-throughput computational screening and in vitro evaluation identifies 5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl) phenyl]-1H-isoindole-1,3(2H)-dione (C3), as a novel EGFR—HER2 dual inhibitor in gastric tumors

    MESFER AL SHAHRANI, REEM GAHTANI, MOHAMMAD ABOHASSAN, MOHAMMAD ALSHAHRANI, YASSER ALRAEY, AYED DERA, MOHAMMAD RAJEH ASIRI, PRASANNA RAJAGOPALAN*

    Oncology Research, Vol.32, No.2, pp. 251-259, 2024, DOI:10.32604/or.2023.043139

    Abstract Gastric cancers are caused primarily due to the activation and amplification of the EGFR or HER2 kinases resulting in cell proliferation, adhesion, angiogenesis, and metastasis. Conventional therapies are ineffective due to the intra-tumoral heterogeneity and concomitant genetic mutations. Hence, dual inhibition strategies are recommended to increase potency and reduce cytotoxicity. In this study, we have conducted computational high-throughput screening of the ChemBridge library followed by in vitro assays and identified novel selective inhibitors that have a dual impediment of EGFR/HER2 kinase activities. Diversity-based High-throughput Virtual Screening (D-HTVS) was used to screen the whole ChemBridge small molecular library against EGFR and… More > Graphic Abstract

    High-throughput computational screening and <i>in vitro</i> evaluation identifies 5-(4-oxo-4H-3,1-benzoxazin-2-yl)-2-[3-(4-oxo-4H-3,1-benzoxazin-2-yl) phenyl]-1H-isoindole-1,3(2H)-dione (C3), as a novel EGFR—HER2 dual inhibitor in gastric tumors

  • Open Access

    ARTICLE

    Identification and validation of novel prognostic fatty acid metabolic gene signatures in colon adenocarcinoma through systematic approaches

    HENG ZHANG1,#, WENJING CHENG2,#, HAIBO ZHAO2, WEIDONG CHEN2, QIUJIE ZHANG2,*, QING-QING YU2,*

    Oncology Research, Vol.32, No.2, pp. 297-308, 2024, DOI:10.32604/or.2023.043138

    Abstract Background: Colorectal cancer (CRC) belongs to the class of significantly malignant tumors found in humans. Recently, dysregulated fatty acid metabolism (FAM) has been a topic of attention due to its modulation in cancer, specifically CRC. However, the regulatory FAM pathways in CRC require comprehensive elucidation. Methods: The clinical and gene expression data of 175 fatty acid metabolic genes (FAMGs) linked with colon adenocarcinoma (COAD) and normal cornerstone genes were gathered through The Cancer Genome Atlas (TCGA)-COAD corroborating with the Molecular Signature Database v7.2 (MSigDB). Initially, crucial prognostic genes were selected by uni- and multi-variate Cox proportional regression analyses; then, depending… More >

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