JINGWEI JIANG^1,2, BO JIA³, CHUAN WANG³, CHEN FANG¹, YUGUI LI¹, GUOXING LING¹, BAOSHI ZHENG^1,*, CHENG LUO^1,*

BIOCELL, Vol.49, No.1, pp. 61-78, 2025, DOI:10.32604/biocell.2024.056981 - 24 January 2025

Abstract The role and regulatory mechanisms of macrophage polarization in cardiac transplantation have gained significant attention. Macrophages can polarize into either the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype in response to environmental cues. M1 macrophages facilitate transplant rejection by releasing inflammatory mediators and activating T cells, whereas M2 macrophages support graft survival by secreting anti-inflammatory factors and promoting tissue repair. Mitochondrial quality control regulation plays a crucial role in macrophage polarization, which may influence graft survival and immune responses. This review provides an overview of the current understanding of mitochondrial quality control-regulated macrophage polarization in cardiac More >

Ryan G. McQueen¹, Nikki M. Singh², Ronald K. Woods^3,*

Congenital Heart Disease, Vol.19, No.3, pp. 257-266, 2024, DOI:10.32604/chd.2024.052108 - 26 July 2024

Abstract Objective: The objective of this study was to compare cardiac transplant operative and postoperative courses of patients with failed Fontan physiology who were initially palliated with a Norwood (FFN) to those without a prior Norwood (FF). Methods: A single-institution retrospective review of all patients with Fontan failure who underwent cardiac transplantation from 2003–2021 was completed—22 underwent prior Norwood (FFN) and 11 did not (FF). Descriptive and inferential statistics were calculated for operative course and patient outcomes. Results: The operative course of the FFN cohort appeared to be more complex (not statistically significant, but clinically relevant)—this group… More >