Zheng LI1, §, Zhongle ZHAO2, §, Peng ZHANG3
BIOCELL, Vol.43, No.3, pp. 183-190, 2019, DOI: 10.32604/biocell.2019.06922
Abstract Stroke remains the leading cause of death and disability worldwide, which destroys the quality of patients’
lives and thus is becoming a heavy burden to the society. However, the current therapeutic approaches are far from
satisfaction. The objective of this study is to elucidate the impact of nerve growth factor (NGF) on the brain damage
induced by cerebral ischemia and its potential molecular mechanism. Middle cerebral artery occlusion (MCAO) rats
were used as animal models and neurological functions were evaluated by modified Neurological Severity Score (NSS).
Brain cell apoptosis was analyzed by TUNEL-positive staining while brain infarct size was determined… More >
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