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    Nerve growth factor alleviates cerebral infarction and neurologic deficits by regulating VEGF, SDF-1 and S100A12 expression through PI3K pathway

    Zheng LI1, §, Zhongle ZHAO2, §, Peng ZHANG3

    BIOCELL, Vol.43, No.3, pp. 183-190, 2019, DOI: 10.32604/biocell.2019.06922

    Abstract Stroke remains the leading cause of death and disability worldwide, which destroys the quality of patients’ lives and thus is becoming a heavy burden to the society. However, the current therapeutic approaches are far from satisfaction. The objective of this study is to elucidate the impact of nerve growth factor (NGF) on the brain damage induced by cerebral ischemia and its potential molecular mechanism. Middle cerebral artery occlusion (MCAO) rats were used as animal models and neurological functions were evaluated by modified Neurological Severity Score (NSS). Brain cell apoptosis was analyzed by TUNEL-positive staining while brain infarct size was determined… More >

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