JUN ZHANG, YEHONG HUANG, WENZHUO LIU, LULU LI, LIMING CHEN*
BIOCELL, Vol.44, No.4, pp. 591-595, 2020, DOI:10.32604/biocell.2020.011642
Abstract Estrogen receptor alpha (ERα/ESR1) is overexpressed in over half of all breast cancers and is considered a
valuable therapeutic target in ERα positive breast cancer. Here, we designed a membrane-permeant Chaperonemediated Autophagy Targeting Chimeras (CMATAC) peptide to knockdown endogenous ERα protein through
chaperone-mediated autophagy. The peptide contains a cell membrane-penetrating peptide (TAT) that allows the
peptide to by-pass the plasma membrane, an αI peptide as a protein-binding peptide (PBD) that binds specifically to
ERα, and CMA-targeting peptide (CTM) that targeting chaperone-mediated autophagy. We validated that ERα
targeting peptide was able to target and degrade ERα to reduce the viability of… More >
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