Jing Zeng*1, Tianping Du†1, Yafeng Song‡, Yan Gao‡, Fuyan Li‡, Ruimin Wu‡, Yijia Chen‡, Wei Li‡, Hong Zhou‡, Yi Yang‡, Zhijun Pei‡
Oncology Research, Vol.28, No.5, pp. 551-552, 2020, DOI:10.3727/096504020X16032056440085
Abstract Long noncoding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) has been demonstrated to play
an important role in diverse tumorigenesis. However, the biological function of lncRNAs in glioma is still
unknown. In this study, we found that lncRNA CCAT2 was overexpressed in glioma tissues and cell lines and
associated with tumor grade and size. Furthermore, patients with high levels of lncRNA CCAT2 had poorer
survival than those with lower levels of lncRNA CCAT2. Knocking down lncRNA CCAT2 expression significantly suppressed the glioma cell growth, migration, and invasion, as well as induced early apoptosis of glioma
cells in vitro. Moreover, lncRNA… More >
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