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Knockdown of Long Noncoding RNA CCAT2 Inhibits Cellular Proliferation, Invasion, and Epithelial–Mesenchymal Transition in Glioma Cells
Jing Zeng*1, Tianping Du†1, Yafeng Song‡, Yan Gao‡, Fuyan Li‡, Ruimin Wu‡, Yijia Chen‡, Wei Li‡, Hong Zhou‡, Yi Yang‡, Zhijun Pei‡
* Department of Infection Control, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China
† Department of Neurosurgery, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China
‡ Department of PET Center and Institute of Anesthesiology and Pain, Taihe Hospital, Hubei University of Medicine,
Shiyan, Hubei Province, P.R. China
Oncology Research 2020, 28(5), 551-552. https://doi.org/10.3727/096504020X16032056440085
Abstract
Long noncoding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) has been demonstrated to play
an important role in diverse tumorigenesis. However, the biological function of lncRNAs in glioma is still
unknown. In this study, we found that lncRNA CCAT2 was overexpressed in glioma tissues and cell lines and
associated with tumor grade and size. Furthermore, patients with high levels of lncRNA CCAT2 had poorer
survival than those with lower levels of lncRNA CCAT2. Knocking down lncRNA CCAT2 expression significantly suppressed the glioma cell growth, migration, and invasion, as well as induced early apoptosis of glioma
cells in vitro. Moreover, lncRNA CCAT2 regulated epithelial–mesenchymal transition (EMT)-associated gene
expression. In conclusion, lncRNA CCAT2 plays an important role in glioma tumorigenesis and progression
and may act as a potential biomarker for therapeutic strategy and prognostic prediction.
Keywords
Cite This Article
Zeng, J., Du, T., Song, Y., Gao, Y., Li, F. et al. (2020). Knockdown of Long Noncoding RNA CCAT2 Inhibits Cellular Proliferation, Invasion, and Epithelial–Mesenchymal Transition in Glioma Cells.
Oncology Research, 28(5), 551–552.