XI ZHU^1,2,#, KAI HUANG^3,#, XIAOMING KAO², ZHAOHUI TANG³, WENJIE GUO³, TIANCONG WU^4,*, QIURONG LI^1,2,*

Oncology Research, Vol.33, No.5, pp. 1149-1159, 2025, DOI:10.32604/or.2024.054930 - 18 April 2025

Abstract Background: Colorectal cancer (CRC) holds the third position in global cancer prevalence mortality. Although chemotherapy is a conventional treatment, recent investigations have shed light on the therapeutic potential of the cGAS cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway in CRC management. Despite the primary role of the death domain-associated protein (Daxx) in cellular apoptosis, its influence on the regulation of cGAS-STING activation remains elusive. Methods: The Daxx degradation and speck formation were conducted using immunofluorescence and Western blotting. The Daxx knock-down and over-expression in CRC cells were performed to detect in vivo and in vitro… More >

Xiaojian Chen^1,2,#, Zhujiang Dai^1,#, Qiang Wang³, Wei Chen¹, Yun Liu^1,*, Zhongchuan Wang^1,*

BIOCELL, Vol.49, No.3, pp. 503-518, 2025, DOI:10.32604/biocell.2025.059286 - 31 March 2025

Abstract Background: Nudix Hydrolase 21 (NUDT21) is crucial for the regulation of alternative polyadenylation, with its reduced expression frequently resulting in a shortened mRNA 3^′ untranslated region (UTR), thereby enhancing the protein levels of downstream genes. Although NUDT21 is widely recognized for its tumor-suppressive function in various cancers, its involvement in colorectal cancer (CRC) remains poorly understood. Methods: The expression of NUDT21 in CRC and adjacent normal tissues was analyzed through qPCR, Western blot, and immunohistochemistry (IHC). Additionally, we investigated the correlation between NUDT21 expression and patient prognosis. With Cell Counting Kit-8 assay and Transwell assay, we… More >

JI-SU HAN¹, HYE-JIN BOO¹, JIN WON HYUN¹, HEESANG SONG², IN-YOUB CHANG³, SANG-PIL YOON^1,4,*

Oncology Research, Vol.33, No.4, pp. 873-884, 2025, DOI:10.32604/or.2024.052003 - 19 March 2025

Abstract Background: Chitosan oligosaccharide (COS) is the major degradation product of chitosan by enzymatic processes. COS, with complete water solubility, exerts significant biological effects, including anti-cancer activity. We investigated the anti-tumor effects of COS on colorectal cancer as effective therapeutic methods with low side effects are lacking. Methods: COS was obtained from low molecular weight chitosan by an enzymatic method and the anti-cancer effects were measured by cell viability assay, flow cytometry analysis, Western blotting, and xenograft. Results: COS suppressed the proliferation of SNU-C5 cells compared to other colorectal cancer cells, but higher concentrations were required in… More > Graphic Abstract

WEI ZHANG^1,3,#, WEICHENG WANG^1,#, RUI WANG¹, XIAO HAN¹, LIJUN ZHU¹, WENJIE GUO^2,*, YANHONG GU^1,*

Oncology Research, Vol.33, No.1, pp. 225-234, 2025, DOI:10.32604/or.2024.050047 - 20 December 2024

Abstract Background: As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating CRC. Methods and Materials: We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against tumors.… More > Graphic Abstract

YAJUN CAO^1,2,3,#, SHUANG YIN^1,2,#, YIDAN FANG⁴, JIEXIAN ZHOU^3,*, YOUTAN LIU^1,2,*

BIOCELL, Vol.48, No.12, pp. 1773-1780, 2024, DOI:10.32604/biocell.2024.056374 - 30 December 2024

Abstract Background: De novo lipogenesis (DNL) is a critical event for the development of tumors, in the present work, we revealed the role of propofol in colorectal cancer (CRC) cell proliferation. Methods: Western blotting (WB), Real-time PCR, and luciferase combined with chromatin immunoprecipitation (ChIP) were used to identify the mechanism underlying propofol-modulated cell proliferation in CRC cells. Results: Herein, we showed that propofol suppressed cell proliferation, which was attributed to the inhibition of DNL characterized by reduced fatty acid synthase (FASN), acetyl-coA carboxylase alpha (ACCA), and stearoyl-coA desaturase-1 (SCD1) expression. Mechanically, propofol stimulation decreased sterol regulatory element-binding proteins-1c (SREBP-1c) More >

ZEYIN LAI¹, HANGYUAN ZHAO¹, HONG DENG^1,2,*

BIOCELL, Vol.48, No.11, pp. 1569-1578, 2024, DOI:10.32604/biocell.2024.053983 - 07 November 2024

Abstract In the development of colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) play a pivotal role in establishing tumor-permissive extracellular matrix structures, angiogenesis, and modulating the immune status of the tumor microenvironment (TME), thereby influencing tumor metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effects of CAFs in the TME may be attributed to the heterogeneous origin and high plasticity of their population. Given the specificity of CAFs, they provide a variety of potential target molecules for future CRC treatment, which may play an indispensable role in CRC therapeutic strategies. This review summarizes the origin of More >

YONGJIAN HUANG, JINZHOU WANG, JIUHUA XU, NING RUAN^*

Oncology Research, Vol.32, No.11, pp. 1765-1776, 2024, DOI:10.32604/or.2024.045564 - 16 October 2024

Abstract Background: Despite significant advancements in the development of anticancer therapies over the past few decades, the clinical management of colorectal cancer remains a challenging task. This study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal cancer. Materials and Methods: Liposomes consisting of 3β-[N-(N′, N′-dimethylamino ethane)carbamoyl]-cholesterol (DC-CHOL), cholesterol (CHOL), and dioleoylphosphatidylethanolamine (DOPE) at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand (pTRAIL) gene, along with the toll-like receptor (TLR7) agonist Rsiquimod (R848). The rationale behind this design is that More > Graphic Abstract

Xia Sun^1,#, Qin Li^1,#, Yang Li², Wenjun Yan³, Shuai Gong¹, Wenjing Yan^2,*

Psycho-Oncologie, Vol.18, No.3, pp. 233-240, 2024, DOI:10.32604/po.2024.048087 - 12 September 2024

Abstract Colorectal cancer (CRC) poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth (PTG) for patient well-being. This study aims to investigate the effects of positive psychological capital (PsyCap) and perceived stress on mediating the social support-PTG relation among 673 CRC patients. Social support, positive PsyCap, perceived stress, and PTG were assessed through questionnaires. The results indicated a direct prediction effect of social support on PTG (LICI = 0.481, ULCI = 0.644), with the direct effect being 59.5%. Both positive PsyCap and perceived stress exerted a mediating role in the… More >

HAOTONG SUN^1,2,#, HEYING WANG^1,2,#, YANJIE HAO^1,2, XIN LI^1,2, JUN LING^1,2, HUAN WANG^1,2, FEIMIAO WANG^1,2, FANG XU^1,2,*

BIOCELL, Vol.48, No.9, pp. 1311-1322, 2024, DOI:10.32604/biocell.2024.052451 - 04 September 2024

Abstract Background: Colorectal cancer is a major global health concern, exacerbated by tumor necrosis factor-alpha(TNF-α) and its role in inflammation, with the effects of Mitotic Arrest Deficient 2 Like 2 (MAD2L2) in this context still unclear. Methods: The colorectal carcinoma cell lines HCT116 and SW620 were exposed to TNF-α for a period of 24 h to instigate an inflammatory response. Subsequent assessments were conducted to measure the expression of inflammatory cytokines, the activity within the p38 mitogen-activated protein kinase (p38 MAPK) and Phosphoinositide 3-Kinase/AKT Serine/Threonine Kinase pathway (PI3K/AKT) signaling cascades. Transcriptome sequencing and subsequent integrative analysis… More >

ROSSANA RONCATO^1,2, JERRY POLESEL³, FEDERICA TOSI^4,5,*, ELENA PERUZZI^1,*, ERIKA BRUGUGNOLI⁶, CLAUDIA LAURIA PANTANO⁷, MARIA FURFARO⁸, FILIPPO DI GIROLAMO^9,10, ALESSANDRO NANI¹¹, ARIANNA PANI⁴, NOEMI MILAN¹, ELENA DE MATTIA¹, ANDREA SARTORE-BIANCHI^4,5, ERIKA CECCHIN¹

Oncology Research, Vol.32, No.9, pp. 1407-1422, 2024, DOI:10.32604/or.2024.049181 - 23 August 2024

Abstract Objectives: Treatment of metastatic colorectal cancer (mCRC) includes resection of liver metastases (LM), however, no validated biomarker identifies patients most likely to benefit from this procedure. This meta-analysis aimed to assess the impact of the most relevant molecular alterations in cancer-related genes of CRC (i.e., RAS, BRAF, SMAD4, PIK3CA) as prognostic markers of survival and disease recurrence in patients with mCRC surgically treated by LM resection. Methods: A systematic literature review was performed to identify studies reporting data regarding survival and/or recurrence in patients that underwent complete liver resection for CRC LM, stratified according to… More > Graphic Abstract