Oncology Research Editorial Office

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.081286 - 23 March 2026

Abstract This article has no abstract. More >

Jiaxi Li^#, Deepak Iyer^#, Siming Sui, Zheng Huang, Ryan Wai-Yan Sin, Abraham Tak-Ka Man, Wai-Lun Law, Chi-Chung Foo^*, Lui Ng^*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074981 - 23 March 2026

Abstract Objectives: Piwi-associated RNAs are small non-coding RNAs implicated in cancer, yet few have been characterized in colorectal cancer (CRC). This study aimed to identify a CRC-related piRNA and investigate its clinical relevance, biological function, and biomarker potential. Methods: Candidates were identified by reanalysis of small-RNA sequencing. piR-37524 was quantified by quantitative real-time polymerase chain reaction (qRT-PCR) in colorectal cancer tissues, matched adjacent non-tumor tissues, colorectal adenomas, liver metastases, and serum samples from patients and healthy controls. Clinicopathological correlations and diagnostic performance were evaluated. Functional assays included 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) proliferation, colony formation, and wound-healing migration… More >

Candela Cives-Losada^1,2, Cristiana Soldani², Michela Anna Polidoro², Barbara Franceschini², Ana Lleo^3,4, Marcello Di Martino^1,5, Matteo Donadon^1,5,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.074093 - 23 March 2026

Abstract Colorectal cancer (CRC) is the second deadliest cancer worldwide, being the presence of metastasis, mainly in the liver, a major contributor to high mortality rates in affected patients. The tumor microenvironment (TME)—comprised of interacting endothelial, stromal, and immune cells—plays a critical role in creating a supportive niche for tumor cell colonization and immune evasion and, thus, the establishment of metastases. The liver’s intrinsic nature further facilitates the development of immune tolerance, mediated by regulatory T cells, myeloid-derived suppressor cells, and soluble factors such as anti-inflammatory cytokines, which together dampen antitumor immune responses. This immunosuppressive milieu More > Graphic Abstract

Yen-Pin Chen^1,2,3, Rathinasamy Baskaran⁴, Hema Sri Devi⁴, Chaouhan Hitesh Singh⁴, Yu-Jung Lin^4,5, Marthandam Asokan Shibu⁶, Wei-Wen Kuo⁷, Shih-Chieh Liao⁸, Ming-Cheng Chen⁹, Tso-Fu Wang¹⁰, Chi-Cheng Li¹¹, Tsung-Jung Ho¹², Tzu-Ching Shih¹³, Shinn-Zong Lin^14,15,16,*, Chih-Yang Huang^4,17,18,19,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073080 - 23 March 2026

Abstract Objective: MicroRNAs (miRNAs) are small, non-coding RNAs that play a key role in the development of chemoresistance in various cancer types, including colorectal cancer (CRC). In this study, we aimed to study the underlying mechanisms of miRNA in chemotherapy-resistant CRC. Methods: LoVo CRC cell line was exposed to oxaliplatin at an increased dose, and cells were cultured in the presence of oxaliplatin to develop LoVoOXR cells. Microarray and Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR), western blot, and transwell assay were used to evaluate the chemoresistance in LoVo^OXR CRC cells. Results: Microarray and qRT-PCR analysis showed… More >

Thomas Kidu¹, Harini Kethar², Haben Gebrekidan³, Haleem Farman⁴, Ahmed Sedik^4,5, Walid El-Shafai^6,7, Jawad Khan^8,*

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.2, 2026, DOI:10.32604/cmes.2026.076798 - 26 February 2026

Abstract Colorectal cancer is the third most diagnosed cancer worldwide, and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups. This study performed a comprehensive analysis of multi-omics data from The Cancer Genome Atlas colorectal adenocarcinoma cohort (TCGA-COADREAD), accessed through cBioPortal, to develop machine learning models for predicting progression-free survival (PFS) following immunotherapy. The dataset included clinical variables, genomic alterations in Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), B-Raf Proto-Oncogene (BRAF), and Neuroblastoma RAS Viral Oncogene Homolog (NRAS), microsatellite instability (MSI) status, tumor mutation burden (TMB), and expression of immune checkpoint genes. Kaplan–Meier… More >

Iara Santos¹, Joana Liberal^1,2, Paulo Teixeira^1,3,4, Diana Martins^1,2,5,6, Fernando Mendes^1,2,5,6,7,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.070281 - 24 February 2026

Abstract Background: The Colorectal Cancer (CRC) pathogenesis and therapeutic efficacy are influenced by the gut microbiome, making it a promising biomarker for predicting treatment responses and adverse effects. This systematic review aims to outline the gut microbiome composition in individuals with CRC undergoing the same therapeutic regimen and evaluate interindividual microbiome profile variations to better understand how these differences may influence therapeutic outcomes. Methods: Key studies investigating the microbiome’s role in therapeutic approaches for CRC were searched in both PubMed and Cochrane databases on 12 and 22 March 2025, respectively. Eligible studies included free full-text English-language… More > Graphic Abstract

Ping Wang^1,2,#, Yan-Han Chen^1,2,#, Ze-Tao Zhan^1,2, Jun-Xiang Zeng^1,2, Yu Chen^3,4, Yuan Lin^1,2, Tao Chen^1,5,*, Wei-Jie Zhou^1,2,5,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071902 - 19 January 2026

Abstract Background: Thimerosal is a mercury-containing preservative widely used in vaccines. This study aimed to investigate its potential antitumor effects and mechanisms in solid malignancies, particularly colorectal cancer (CRC) and melanoma. Methods: A combination of in vitro and in vivo approaches was employed. Cell proliferation, apoptosis, migration, and invasion were assessed using Cell Counting Kit-8 (CCK-8), colony formation, ATP viability, Western blotting, flow cytometry, wound-healing and Transwell assays. Subcutaneous, lung metastases, and Azoxymethane/Dextran Sulfate Sodium Salt (AOM/DSS)-induced colitis-associated CRC models were established to examine antitumor efficacy and safety. The functional role of mercury ions was validated using structural… More >

Mariana Francisco¹, Fernando Mendes^1,2,3,4,5,*, Diana Martins^1,2,3,4, Joana Liberal^1,2

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070276 - 19 January 2026

Abstract Objectives: Colorectal cancer (CRC) is a major global health burden, and Urolithin A (Uro-A) has emerged as a promising anticancer agent. This systematic review aims to synthesize current in vitro evidence on the anticancer effects of Uro-A in CRC, highlighting effective concentration ranges, exposure times, relevant outcomes, and underlying molecular mechanisms. Methods: Following PRISMA 2020 guidelines, a systematic search was conducted in PubMed, Scopus, and Web of Science using the following strategy: (colorectal cancer) AND (urolithin a) OR (3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one). Eligibility criteria were defined by the PICO framework: (P) in vitro CRC cell models; (I) Uro-A alone or… More > Graphic Abstract

Katerina Ondraskova^1,2, Matous Cwik³, Ondrej Horky⁴, Jitka Berkovcova⁴, Jitka Holcakova¹, Martin Bartosik¹, Tomas Kazda⁵, Klara Mrazova^1,6, Michal Uher⁷, Igor Kiss³, Roman Hrstka^1,3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070116 - 19 January 2026

Abstract Objectives: Cancer treatment relies heavily on accurate diagnosis and effective monitoring of the disease. These processes often involve invasive procedures, such as colonoscopy, to detect malignant tissues, followed by molecular analyses to determine relevant biomarkers. This study aimed to evaluate the clinical performance of droplet digital PCR (ddPCR) for detecting Kirsten Rat Sarcoma Viral Proto-Oncogene (KRAS), Neuroblastoma RAS Viral Oncogene Homolog (NRAS), and B-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) mutations in circulating tumor DNA (ctDNA) from colorectal cancer patients using liquid biopsy. Methods: ctDNA was isolated from colorectal cancer (CRC) patients (n = 110) and analyzed for KRAS, BRAF,… More >

Urszula Częścik^1,2,#, Martyna Gryglas³, Arkadiusz Szterk⁴, Sylwia Flis^3,#,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.067449 - 19 January 2026

Abstract Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer-related deaths, accounting for approximately 10% of all cancer cases. By 2050, CRC incidence is expected to rise substantially, driven by population aging and greater exposure to risk factors in developing countries. Despite advances in medicine and pharmacy, the effectiveness of available treatments remains limited, underscoring the urgent need for innovative therapeutic strategies. This review summarizes and critically evaluates currently available CRC therapies and explores new emerging directions. Particular attention is given to the role of immunotherapy, targeted therapies,… More >