TRINIDAD MONTERO-VILCHEZ^1,2,*, MANUEL SANCHEZ-DIAZ^1,2, CAROLINA MONTERO-VILCHEZ³, ALVARO SIERRA-SANCHEZ², SALVADOR ARIAS-SANTIAGO^1,2,4

BIOCELL, Vol.46, No.11, pp. 2363-2367, 2022, DOI:10.32604/biocell.2022.021399

Abstract Atopic dermatitis (AD) is a chronic cutaneous inflammatory disease caused by an interaction between genetic, immune and epidermal barrier factors. Several treatments can be used to treat this disease but there are patients that do not respond to actual drugs. So, there is a need to develop effective therapies for AD. Mesenchymal stem cells (MSCs) are non-hematopoietic multipotent adult progenitor cells with immunomodulatory power and self-regenerating capacity to repair tissue damage, so they could be a potential effective treatment for AD. MSCs-Conditioned Medium (CM) and MSCs-exosomes are cell-free preparation with molecules secreted by stem cells that could be also beneficial… More >

XINWEI WU¹, GUOYONG JIA^2,*, HONGNA YANG³, CONGCONG SUN², YING LIU², ZENGYAN DIAO²

BIOCELL, Vol.46, No.2, pp. 471-478, 2022, DOI:10.32604/biocell.2021.015701

Abstract A progressive neurodegenerative disease, Alzheimer’s disease (AD). Studies suggest that highly expressed protein isoaspartate methyltransferase 1 (PCMT1) in brain tissue. In the current study, we explored the effects of neural stem cell-conditioned medium (NSC-CDM) on the PCMT1/MST1 pathway to alleviate Aβ_25-35-induced damage in SH-SY5Y cells. Our data suggested that Aβ25-35 markedly inhibited cell viability. NSC-CDM or Neural stem cell-complete medium (NSC-CPM) had a suppression effect on toxicity when treatment with Aβ_25-35, with a greater effect observed with NSC-CDM. Aβ_25-35 + NSC-CDM group exhibited an increase in PCMT1 expression. sh-PCMT1 markedly decreased cell proliferation and suppressed the protective role of NSC-CDM… More >