Helia Mojtabavi^1,2, Amene Saghazadeh^1,2, Nima Rezaei^2,3,4

European Cytokine Network, Vol.31, No.2, pp. 44-49, 2020, DOI:10.1684/ecn.2020.0448

Abstract Background: Evidence links COVID-19 severity to hyper-inflammation. Treatment with tocilizumab, a monoclonal antibody directed against the interleukin-6 (IL-6) receptor, was shown to lead to clinical improvement in patients with severe COVID-19. We, therefore, performed the present systematic review and meta-analysis to investigate whether the circulating levels of IL-6 is a reliable indicator of disease severity among patients affected with COVID-19. Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, and Google Scholar on April 19, 2020. Results: Eleven studies provided data of IL-6 levels in patients with severe to critical COVID-19 (severe)… More >

Negar Moradian^1,2, Mahdi Gouravani^1,2, Mohammad Amin Salehi^1,2, Arash Heidari^1,2, Melika Shafeghat^1,2, Michael R. Hamblin^3,4,5, Nima Rezaei^1,2,6

European Cytokine Network, Vol.31, No.3, pp. 81-93, 2020, DOI:10.1684/ecn.2020.0451

Abstract Coronavirus disease (COVID-19) reached pandemic proportions at the beginning of 2020 and continues to be a worldwide concern. End organ damage and acute respiratory distress syndrome are the leading causes of death in severely or critically ill patients. The elevated cytokine levels in severe patients in comparison with mildly affected patients suggest that cytokine release syndrome (CRS) occurs in the severe form of the disease. In this paper, the significant role of pro-inflammatory cytokines, including IL-1, IL-6, and TNF-alpha, and their mechanism of action in the CRS cascade is explained. Potential therapeutic approaches involving anti-IL-6 More >

Benjamin Schrijver^1,a, Jorn L. J. C. Assmann^1,a, Adriaan J. van Gammeren², Roel C. H. Vermeulen³, Lützen Portengen³, Peter Heukels⁴, Anton W. Langerak¹, Willem A. Dik¹, Vincent H. J. van der Velden^1,b, Ton A. A. M. Ermens^2,b

European Cytokine Network, Vol.31, No.4, pp. 154-167, 2020, DOI:10.1684/ecn.2020.0456

Abstract COVID-19 differs substantially between individuals, ranging from mild to severe or even fatal. Heterogeneity in the immune response against SARS-COV-2 likely contributes to this. Therefore, we explored the temporal dynamics of key cellular and soluble mediators of innate and adaptive immune activation in relation to COVID-19 severity and progression.
Forty-four patients with a PCR-proven diagnosis of COVID-19 were included. Extensive cellular (leukocytes and T-lymphocyte subsets) and serological immune profiling (cytokines, soluble cell surface molecules, and SARS-CoV-2 antibodies) was performed at hospital admission and every 3-4 days during hospitalization. Measurements and disease outcome were compared between… More >

Vipin Tyagi¹, Ajay Kumar Sharma², Mahendra Bhandari³

Canadian Journal of Urology, Vol.27, No.3, pp. 10205-10212, 2020

Abstract Introduction: The novel coronavirus disease 2019 (COVID-19) pandemic has afflicted > 3.3 million people around the world since December 2019. Though more than 1000 publications have appeared in scientific journals addressing a plethora of questions, there is a considerable hiatus in understanding the behavior and natural history of the virus and its impact on urology. Also, a modified approach is the need of the hour in taking care of patients, as urologists should safeguard their teams, families, and patients.
Material and methods: The authors have used guidelines from the USA, Canada, UK, Europe, and India for making… More >

Leonard G. Gomella

Canadian Journal of Urology, Vol.27, No.5, pp. 10346-10346, 2020

Abstract This article has no abstract. More >

VIVEK KUMAR, VISHNU AGARWAL^*

BIOCELL, Vol.44, No.4, pp. 461-467, 2020, DOI:10.32604/biocell.2020.011090 - 24 December 2020

Abstract The world is facing a new healthcare crisis with the rise and spread of novel coronavirus since December 2019. Also known as Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), the disease associated with SARSCoV-2 is even called COVID-19. The infection is said to have originated from the bat community and transmitted to humans through an intermediate host (yet unknown) in Wuhan, in the Hubei region of China. COVID-19 is having a pulverizing impact on the scientific community. As of August 13, 2020, the number of confirmed cases had reached up to 20,439,814 and the death More >

Hamed Rezapouraghdam¹, Osman M. Karatepe^2,*

International Journal of Mental Health Promotion, Vol.22, No.4, pp. 233-247, 2020, DOI:10.32604/IJMHP.2020.013214 - 22 December 2020

Abstract The overwhelming majority of the countries around the globe have witnessed severe cases of the COVID-19 outbreak. Unfortunately, many countries are still beset with such an infectious disease. Despite the fact that there is currently no specific approved cure for this deadly infection, restrictions (e.g., lockdown and border closing) are gradually eased. Meanwhile, businesses are reopening and outdoor leisure activities are about to start again based on strict health, social distancing, and hygiene rules. However, as we still have a long way to reach an ultimate treatment for such deadly virus, changing human behavior sounds… More >

Meenu Gupta¹, Rachna Jain², Akash Gupta^2,*, Kunal Jain²

CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.3, pp. 943-965, 2020, DOI:10.32604/cmes.2020.012467 - 15 December 2020

Abstract The spread of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has already taken on pandemic extents, inuencing even more than 200 nations in a couple of months. Although, regulation measures in China have decreased new cases by over 98%, this decrease is not the situation everywhere, and most of the countries still have been affected by it. The objective of this research work is to make a comparative analysis of the top 5 most populated countries namely United States, India, China, Pakistan and Indonesia, from 1st January 2020 to 31st July 2020. This research… More >

Yupaporn Areepong¹, Rapin Sunthornwat^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.3, pp. 927-942, 2020, DOI:10.32604/cmes.2020.012323 - 15 December 2020

Abstract Coronavirus disease 2019 outbreak has spread as a pandemic since the end of year 2019. This situation has been causing a lot of problems of human beings such as economic problems, health problems. The forecasting of the number of infectious people is required by the authorities of all countries including Southeast Asian countries to make a decision and control the outbreak. This research is to investigate the suitable forecasting model for the number of infectious people in Southeast Asian countries. A comparison of forecasting models between logistic growth curve which is symmetric and Gompertz growth More >

Mohammad Zuber¹, John Valerian Corda¹, Milad Ahmadi², B. Satish Shenoy¹, Irfan Anjum Badruddin^3,*, Ali E. Anqi³, Kamarul Arifin Ahmad⁴, S. M. Abdul Khader⁵, Leslie Lewis⁶, Mohammad Anas Khan⁷, Sarfaraz Kamangar³

CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.3, pp. 1185-1199, 2020, DOI:10.32604/cmes.2020.015015 - 15 December 2020

Abstract The novel coronavirus responsible for COVID-19 has spread to several countries within a considerably short period. The virus gets deposited in the human nasal cavity and moves to the lungs that might be fatal. As per safety guidelines by the World Health Organization (WHO), social distancing has emerged as one of the major factors to avoid the spread of infection. However, different guidelines are being followed across the countries with regards to what should be the safe distance. Thus, the current work is an attempt to understand the virus deposition pattern in the realistic human… More >