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  • Open Access

    REVIEW

    Role of RIPK1 in the pathogenesis of acute respiratory distress syndrome

    XUNAN ZHAO#, EMMANUEL MAGO#, DAN WENG*

    BIOCELL, Vol.47, No.10, pp. 2151-2162, 2023, DOI:10.32604/biocell.2023.030570

    Abstract Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary disease typically caused by microbial infections, trauma, inhalation of harmful gases, and other factors. It is characterized by an inflammation in the lungs and increased alveolar permeability, leading to pulmonary edema and consequently, a low oxygen supply or hypoxemia. ARDS is responsible for 1 in 10 admissions to intensive care units, and the mortality rate for patients with severe ARDS is as high as 46%. Extensive efforts have been devoted to investigating the pathological mechanisms of ARDS to develop new effective clinical strategies. Recent studies have reported that receptor-interacting serine/threonine kinase… More > Graphic Abstract

    Role of RIPK1 in the pathogenesis of acute respiratory distress syndrome

  • Open Access

    ARTICLE

    Deep Learning-Based Trees Disease Recognition and Classification Using Hyperspectral Data

    Uzair Aslam Bhatti1,*, Sibghat Ullah Bazai2, Shumaila Hussain1, Shariqa Fakhar3, Chin Soon Ku4,*, Shah Marjan5, Por Lip Yee6, Liu Jing1

    CMC-Computers, Materials & Continua, Vol.77, No.1, pp. 681-697, 2023, DOI:10.32604/cmc.2023.037958

    Abstract Crop diseases have a significant impact on plant growth and can lead to reduced yields. Traditional methods of disease detection rely on the expertise of plant protection experts, which can be subjective and dependent on individual experience and knowledge. To address this, the use of digital image recognition technology and deep learning algorithms has emerged as a promising approach for automating plant disease identification. In this paper, we propose a novel approach that utilizes a convolutional neural network (CNN) model in conjunction with Inception v3 to identify plant leaf diseases. The research focuses on developing a mobile application that leverages… More >

  • Open Access

    ARTICLE

    Polo-like kinase 1 suppresses lung adenocarcinoma immunity through necroptosis

    PENGCHENG ZHANG1,#,*, XINGLONG ZHANG2,#, YONGFU ZHU3, YIYI CUI1, JING XU4, WEIPING ZHANG1,*

    Oncology Research, Vol.31, No.6, pp. 937-953, 2023, DOI:10.32604/or.2023.030933

    Abstract Polo-like kinase 1 (PLK1) plays a crucial role in cell mitosis and has been associated with necroptosis. However, the role of PLK1 and necroptosis in lung adenocarcinoma (LA) remains unclear. In this study, we analyzed The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression databases to evaluate the prognostic value and mechanistic role of PLK1 in LA. PLK1 was found to be highly expressed in LA and was positively associated with advanced disease staging and poor survival outcomes. Functional enrichment analysis showed that PLK1 was involved in cell mitosis, neurotransmitter transmission, and drug metabolism. Further analysis using single-sample gene set enrichment… More > Graphic Abstract

    Polo-like kinase 1 suppresses lung adenocarcinoma immunity through necroptosis

  • Open Access

    ARTICLE

    ScRNA-seq reveals the correlation between M2 phenotype of tumor-associated macrophages and lymph node metastasis of breast cancer

    JUN SHEN1,#, HONGFANG MA2,#, YONGXIA CHEN3, JIANGUO SHEN1,*

    Oncology Research, Vol.31, No.6, pp. 955-966, 2023, DOI:10.32604/or.2023.029638

    Abstract The process of lymphatic metastasis was proved to be associated with podoplanin-expressing macrophages in breast cancer (BC). This study aimed to investigate the role of the M2 phenotype of tumor-associated macrophages and mine the key M2 macrophages-related genes for lymph node metastasis in BC. We downloaded the GSE158399 dataset from the Gene Expression Omnibus (GEO) database, which includes transcriptomic profiles of individual cells from primary tumors, negative lymph nodes (NLNs), and positive lymph nodes (PLNs) of breast cancer patients. The cell subsets were identified by clustering analysis after quality control of the scRNA-seq using Seurat. The activation and migration capability… More >

  • Open Access

    ARTICLE

    Increasing Crop Quality and Yield with a Machine Learning-Based Crop Monitoring System

    Anas Bilal1,*, Xiaowen Liu1, Haixia Long1,*, Muhammad Shafiq2, Muhammad Waqar3

    CMC-Computers, Materials & Continua, Vol.76, No.2, pp. 2401-2426, 2023, DOI:10.32604/cmc.2023.037857

    Abstract Farming is cultivating the soil, producing crops, and keeping livestock. The agricultural sector plays a crucial role in a country’s economic growth. This research proposes a two-stage machine learning framework for agriculture to improve efficiency and increase crop yield. In the first stage, machine learning algorithms generate data for extensive and far-flung agricultural areas and forecast crops. The recommended crops are based on various factors such as weather conditions, soil analysis, and the amount of fertilizers and pesticides required. In the second stage, a transfer learning-based model for plant seedlings, pests, and plant leaf disease datasets is used to detect… More >

  • Open Access

    PROCEEDINGS

    Magnetic Micropillar Structures for Programmable and Reprogrammable Actuation

    Ke Ni1, Zhengzhi Wang1,2,3,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.4, pp. 1-2, 2023, DOI:10.32604/icces.2023.09248

    Abstract Stimuli-responsive micropillar structures that can perform dynamics and reversible deformations according to external stimuli have been applied in a wide spectrum of fields, including object manipulation, soft miniature robots, and functional surfaces. However, it remains a challenge to exhibit programmable actuation behaviors for applications that require on-demand deformation response. Herein, a two-step photomask-assisted template casting technique is developed to fabricate a hybrid magnetic micropillar array for programmable actuation. By modulating the spatial distribution of the magnetic nanoparticles within the elastomer micropillars, the bending deformations of the micropillars with different particle distributions can vary near one order of magnitude under the… More >

  • Open Access

    ARTICLE

    Automatic Crop Expert System Using Improved LSTM with Attention Block

    Shahbaz Sikandar1, Rabbia Mahum1, Suliman Aladhadh2,*

    Computer Systems Science and Engineering, Vol.47, No.2, pp. 2007-2025, 2023, DOI:10.32604/csse.2023.037723

    Abstract Agriculture plays an important role in the economy of any country. Approximately half of the population of developing countries is directly or indirectly connected to the agriculture field. Many farmers do not choose the right crop for cultivation depending on their soil type, crop type, and climatic requirements like rainfall. This wrong decision of crop selection directly affects the production of the crops which leads to yield and economic loss in the country. Many parameters should be observed such as soil characteristics, type of crop, and environmental factors for the cultivation of the right crop. Manual decision-making is time-taking and… More >

  • Open Access

    ARTICLE

    INFLUENCE OF CONVECTIVE BOUNDARY CONDITION ON NONLINEAR THERMAL CONVECTION FLOW OF A MICROPOLAR FLUID SATURATED POROUS MEDIUM WITH HOMOGENEOUS-HETEROGENEOUS REACTIONS

    Chetteti RamReddya,†, Teegala Pradeepaa

    Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-10, 2017, DOI:10.5098/hmt.8.6

    Abstract A numerical approach has been used to analyze the effects of homogeneous-heterogeneous reaction and nonlinear density temperature variation over a vertical plate in an incompressible micropolar fluid flow saturated Darcy porous medium. In addition, convective boundary condition is incorporated in a micropolar fluid model. The similarity representation for the set of partial differential equations is attained by applying Lie group transformations. The resulting non-dimensional equations are worked out numerically by spectral quasi-linearization method. Less temperature and wall couple stress coefficient, but more velocity, skin friction, species concentration, and heat transfer rate are noticed by enhancing the nonlinear convection parameter. It… More >

  • Open Access

    ARTICLE

    NEW SIMILARITY SOLUTION OF MICROPOLAR FLUID FLOW PROBLEM OVER AN UHSPR IN THE PRESENCE OF QUARTIC KIND OF AUTOCATALYTIC CHEMICAL REACTION

    O. K. Koriko, I. L. Animasaun*

    Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-13, 2017, DOI:10.5098/hmt.8.26

    Abstract The motion of air (i.e fluid) in which tiny particle rotates past a pointed surface of a rocket (as in space science), over a bonnet of a car and past a pointed surface of an aircraft is of important to experts in all these fields. Geometrically, all the domains of fluid flow in all these cases can be referred to as the upper horizontal surface of a paraboloid of revolution (uhspr). Meanwhile, the solution of the corresponding partial differential equation is an open question due to unavailability of suitable similarity variable to non-dimensionalize the angular momentum equation. This article unravels… More >

  • Open Access

    ARTICLE

    EFFECTS OF HOMOGENEOUS-HETEROGENEOUS CHEMICAL REACTION AND SLIP VELOCITY ON MHD STAGNATION FLOW OF A MICROPOLAR FLUID OVER A PERMEABLE STRETCHING/SHRINKING SURFACE EMBEDDED IN A POROUS MEDIUM

    P. Bala Anki Reddya,*, S. Suneethab

    Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-11, 2017, DOI:10.5098/hmt.8.24

    Abstract We report on a mathematical model for analyzing the effects of homogeneous-heterogeneous chemical reaction and slip velocity on the MHD stagnation point flow of electrically conducting micropolar fluid over a stretching/shrinking surface embedded in a porous medium. The governing boundary layer coupled partial differential equations are transformed into a system of non-linear ordinary differential equations, which are solved numerically using the MATLAB bvp4c solver. The effects of physical and fluid parameters such as the stretching parameter, micropolar parameter, permeability parameter, strength of homogeneous and heterogeneous reaction parameter on the velocity and concentration are analyzed, and these results are presented through… More >

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