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    Knockdown of DDX5 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer

    Zhenchuan Ma*, Jie Feng, Yurui Guo, Ranran Kong*, Yuefeng Ma*, Liangzhang Sun*, Xiaoping Yang*, Bin Zhou*, Shaomin Li*, Wei Zhang*, Jiantao Jiang*, Jin Zhang*, Zhe Qiao*, Yao Cheng*, Danjie Zha*, Shiyuan Liu*

    Oncology Research, Vol.25, No.6, pp. 887-895, 2017, DOI:10.3727/096504016X14817158982636

    Abstract DEAD (Asp-Glu-Ala-Asp) box protein 5 (DDX5), a prototypical member of the DEAD/H-box protein family, has been involved in several human malignancies. However, the expression and biological role of DDX5 in esophageal cancer (EC) remain largely unknown. In this study, we examined the role of DDX5 in regulating EC cell proliferation and tumorigenesis and explored its possible molecular mechanism. We found that DDX5 was overexpressed in human EC cell lines. In addition, knockdown of DDX5 significantly inhibited the proliferation of EC cells in vitro and the growth of EC xenografts in vivo. Knockdown of DDX5 also More >

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