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  • Open Access

    ARTICLE

    Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

    WEN YANG, BIN TANG, DAN XU, WENXIU YANG*

    Oncology Research, Vol.33, No.1, pp. 199-212, 2025, DOI:10.32604/or.2024.050036 - 20 December 2024

    Abstract Background: The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma (DLBCL) has been reported previously. However, the detailed mechanisms of CCR7 in DLBCL, particularly regarding its interaction with lenalidomide treatment, are not fully understood. Methods: Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control groups. Immunohistochemical data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of DLBCL. Furthermore, in vitro and in vivo experiments were conducted to clarify the… More > Graphic Abstract

    Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

  • Open Access

    ARTICLE

    Effect of Shading on Nodule Growth at Seedling Stage in Relay Strip Intercropping System

    Xiaobo Yu1,2,3, Jiangang An1,3, Mingrong Zhang1,3, Haiying Wu1,3, Taiwen Yong2, Wenyu Yang2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3387-3399, 2024, DOI:10.32604/phyton.2024.058494 - 31 December 2024

    Abstract Relay strip intercropping (RSI) increases soybean nodule number and nitrogen fixation activity at the reproductive stage more than monocropping (M), but the effect of changes in the environment, especially light, on nodules during the coexistence duration and vegetative stage, is unclear. To determine the impact of shading on nodule development at the seedling stage, nodule traits, distribution, and physiological function were compared between M and RSI in a potting experiment in a field environment. Compared with M, nodule number and weight decreased significantly (an average of 81.77% and 93.16%, respectively); thus, the exponential relationship… More >

  • Open Access

    ARTICLE

    Using Artificial Intelligence Techniques in the Requirement Engineering Stage of Traditional SDLC Process

    Afam Okonkwo*, Pius Onobhayedo, Charles Igah

    Journal on Artificial Intelligence, Vol.6, pp. 379-401, 2024, DOI:10.32604/jai.2024.058649 - 31 December 2024

    Abstract Artificial Intelligence, in general, and particularly Natural language Processing (NLP) has made unprecedented progress recently in many areas of life, automating and enabling a lot of activities such as speech recognition, language translations, search engines, and text-generations, among others. Software engineering and Software Development Life Cycle (SDLC) is also not left out. Indeed, one of the most critical starting points of SDLC is the requirement engineering stage which, traditionally, has been dominated by business analysts. Unfortunately, these analysts have always done the job not just in a monotonous way, but also in an error-prone, tedious,… More >

  • Open Access

    ARTICLE

    Secure Digital Image Watermarking Technique Based on ResNet-50 Architecture

    Satya Narayan Das1,2,*, Mrutyunjaya Panda2,*

    Intelligent Automation & Soft Computing, Vol.39, No.6, pp. 1073-1100, 2024, DOI:10.32604/iasc.2024.057013 - 30 December 2024

    Abstract In today’s world of massive data and interconnected networks, it’s crucial to burgeon a secure and efficient digital watermarking method to protect the copyrights of digital content. Existing research primarily focuses on deep learning-based approaches to improve the quality of watermarked images, but they have some flaws. To overcome this, the deep learning digital image watermarking model with highly secure algorithms is proposed to secure the digital image. Recently, quantum logistic maps, which combine the concept of quantum computing with traditional techniques, have been considered a niche and promising area of research that has attracted… More >

  • Open Access

    ARTICLE

    Fake News Detection on Social Media Using Ensemble Methods

    Muhammad Ali Ilyas1, Abdul Rehman2, Assad Abbas1, Dongsun Kim3,*, Muhammad Tahir Naseem4,*, Nasro Min Allah5

    CMC-Computers, Materials & Continua, Vol.81, No.3, pp. 4525-4549, 2024, DOI:10.32604/cmc.2024.056291 - 19 December 2024

    Abstract In an era dominated by information dissemination through various channels like newspapers, social media, radio, and television, the surge in content production, especially on social platforms, has amplified the challenge of distinguishing between truthful and deceptive information. Fake news, a prevalent issue, particularly on social media, complicates the assessment of news credibility. The pervasive spread of fake news not only misleads the public but also erodes trust in legitimate news sources, creating confusion and polarizing opinions. As the volume of information grows, individuals increasingly struggle to discern credible content from false narratives, leading to widespread… More >

  • Open Access

    REVIEW

    The Metaverse Review: Exploring the Boundless Ream of Digital Reality

    Shi Dong*, Mengke Liu, Khushnood Abbas

    CMC-Computers, Materials & Continua, Vol.81, No.3, pp. 3451-3498, 2024, DOI:10.32604/cmc.2024.055575 - 19 December 2024

    Abstract The metaverse has emerged as a prominent topic with growing interest fueled by advancements in Web 3.0, blockchain, and immersive technologies. This paper presents a thorough analysis of the metaverse, showcasing its evolution from a conceptual phase rooted in science fiction to a dynamic and transformative digital environment impacting various sectors including gaming, education, healthcare, and entertainment. The paper introduces the metaverse, details its historical development, and introduces key technologies that enable its existence such as virtual and augmented reality, blockchain, and artificial intelligence. Further this work explores diverse application scenarios, future trends, and critical More >

  • Open Access

    ARTICLE

    Seed Priming Improves Chilling Stress Tolerance in Rice (Oryza sativa L.) Seedlings

    Md. Tahjib-Ul-Arif1,2,*, Md Asaduzzaman3, Bir Jahangir Shirazy2,4, Md. Shihab Uddine Khan5, A. M. Sajedur Rahman2,6, Yoshiyuki Murata2, Sozan Abdel Hamed7, Arafat Abdel Hamed Abdel Latef8,9,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 3013-3027, 2024, DOI:10.32604/phyton.2024.058710 - 30 November 2024

    Abstract Chilling is one of the major abiotic stresses for plants, especially for rice cultivation. Many essential metabolic processes for growth and development are temperature-dependent. In that case, reducing the negative effects of cold stress using exogenous chemicals is a possible option. Therefore, the current study examined the effects of pre-sowing seed treatment with different chemicals, viz. hydrogen peroxide (H2O2), salicylic acid (SA), calcium chloride (CaCl2), thiourea (TU), and citric acid (CA) on the germination of rice seeds (cv. BRRI dhan28) under chilling environments. Rice seeds were soaked in distilled water (control), 10 mM CA, 2 mM SA,… More >

  • Open Access

    ARTICLE

    EMS-Mediated Mutagenesis in Marigold Seeds and Its Effects on Seedling Growth and Physiology

    Chao Meng1,#, Ikram Ullah2,#, Wenjin Wu3, Yiping Zhang1, Ruixue Shi1, Shaodan Luo3, Cuixia Luo3, Satyabrata Nanda4, Mahmoud F. Seleiman5, Yalian Jiang1,*, Wangqi Huang1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 3029-3038, 2024, DOI:10.32604/phyton.2024.057857 - 30 November 2024

    Abstract Marigolds (Tagetes spp.) are popular horticultural plants worldwide. The current study aimed to investigate the optimal mutagenic conditions for marigold seeds using EMS (ethyl methanesulfonate) mutagenesis. Different concentrations and treatment times of EMS were applied to investigate their effects on the marigold seed germination rate, growth traits, antioxidant enzyme activities (i.e., SOD and POD), and malondialdehyde (MDA) contents. Results indicated that with increasing the EMS treatment duration and concentration, the seed germination rate and growth treatments were reduced, accompanied by elevated MDA content. In addition, SOD and POD activities initially correlated positively with the growth tratis at More >

  • Open Access

    ARTICLE

    Genome-Wide Identification of the GST Gene Family in Loquat (Eriobotrya japonica Lindl.) and Their Expression under Cold Stress with ALA Pretreatment

    Guanpeng Huang1,#, Ti Wu1,2,#, Yinjie Zheng3, Qiyun Gu2, Qiaobin Chen2, Shoukai Lin2,*, Jincheng Wu2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 2715-2735, 2024, DOI:10.32604/phyton.2024.056484 - 30 November 2024

    Abstract Loquat (Eriobotrya japonica Lindl.), a rare fruit native to China, has a long history of cultivation in China. Low temperature is the key factor restricting loquat growth and severely affects yield. Low temperature induces the regeneration and metabolism of reduced glutathione (GSH) to alleviate stress damage via the participation of glutathione S-transferases (GSTs) in plants. In this study, 16 GSTs were identified from the loquat genome according to their protein sequence similarity with Arabidopsis GSTs. On the basis of domain characteristics and phylogenetic analysis of AtGSTs, these EjGSTs can be divided into 4 subclasses: Phi, Theta, Tau… More >

  • Open Access

    ARTICLE

    Effects of Water-Fertilizer Coupling on Growth Characteristics and Water Use Efficiency of Camellia petelotii Seedlings

    Liangyu Luo1,#, Ru Li1,#, Daocheng Ma1, Yijin Wang2,*, Linghui Wang1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 2927-2947, 2024, DOI:10.32604/phyton.2024.056429 - 30 November 2024

    Abstract Camellia petelotii (Merr.) Sealy is an endangered Chinese native species that originates from Guangxi Zhuang Autonomous Region, China. Previous research demonstrated that proper water and fertilizer treatments could improve the growth and quality of Camellia species. This study uses a three-factor, five-level quadratic rotational combination experimental design to investigate the impact of water-fertilizer coupling on plant growth characteristics and the most suitable treatment for 24-month-old grafted C. petelotii seedlings. The experimental design includes irrigation levels [30%, 40%, 55%, 70%, 80% of field capacity (FC)], nitrogen application (0, 2.17, 5.43, 8.70, 10.87 g·plant−1), and phosphorus application (0, 0.96, 2.40,… More >

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