Takashi Saito^*†, Atsuo Okamura^‡, Junichiro Inoue^†, Daisuke Makiura^†, Hisayo Doi^§, Kimikazu Yakushijin^¶, Hiroshi Matsuoka^¶, Yoshitada Sakai^†#, Rei Ono^*

Oncology Research, Vol.27, No.4, pp. 469-474, 2019, DOI:10.3727/096504018X15267574931782

Abstract Chemotherapy-induced peripheral neuropathy (CIPN) frequently occurs in lymphoma patients receiving R-CHOP, a drug combination therapy. Although severe CIPN may lead to reduction and/or discontinuation of the medication, predictive factors of CIPN have not been investigated sufficiently to date. We performed a retrospective exploratory research to determine associations between prevalence of severe CIPN and sociodemographic data, health characteristics, and medical conditions such as anemia at initial diagnosis. Forty patients (indolent lymphoma, n=9; diffuse large B-cell lymphoma; n=31) received R-CHOP therapy from September 2009 to July 2014. The median age of patients was 58 years (range=27–76 years). Statistical analyses were applied to… More >

Qiuyun Luo^*†1, Wentao Pan^*†‡1, Suna Zhou^*†1, Guangfeng Wang^‡, Hanjie Yi^*§, Lin Zhang^*¶, Xianglei Yan^*†, Luping Yuan^*†, Zhenyi Liu^#, Jing Wang^**, Haibo Chen^#, MiaoZhen Qiu^*††, DaJun Yang^*†‡, Jian Sun^*‡‡

Oncology Research, Vol.28, No.4, pp. 331-344, 2020, DOI:10.3727/096504020X15825405463920

Abstract Despite therapeutic advances, the effective treatment for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) remains a major clinical challenge. Evasion of apoptosis through upregulating antiapoptotic B-cell lymphoma-2 (BCL-2) family members and p53 inactivation, and abnormal activation of B-cell receptor signaling pathway are two important pathogenic factors for DLBCL. In this study, our aim is to explore a rational combination of BCL-2 inhibitor plus Bruton’s tyrosine kinase (BTK) blockade or p53 activation for treating DLBCL with the above characteristics. We demonstrated that a novel BCL-2 selective inhibitor APG-2575 effectively suppressed DLBCL with BCL-2 high expression via activating the mitochondrial apoptosis… More >

Walaa Gad^1,*, Anas Alokla¹, Waleed Nazih², Mustafa Aref¹, Abdel-badeeh Salem¹

CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 3117-3132, 2022, DOI:10.32604/cmc.2022.019884

Abstract Understanding the content of the source code and its regular expression is very difficult when they are written in an unfamiliar language. Pseudo-code explains and describes the content of the code without using syntax or programming language technologies. However, writing Pseudo-code to each code instruction is laborious. Recently, neural machine translation is used to generate textual descriptions for the source code. In this paper, a novel deep learning-based transformer (DLBT) model is proposed for automatic Pseudo-code generation from the source code. The proposed model uses deep learning which is based on Neural Machine Translation (NMT) to work as a language… More >

JIYU WANG^#, YING PAN^#, YANG WAN, ZHIXIANG WANYAN, ZHITAO WANG, QIANSHAN TAO, ZHIMIN ZHAI^*

BIOCELL, Vol.45, No.4, pp. 933-942, 2021, DOI:10.32604/biocell.2021.014280

Abstract The present study aimed to clarify the role of SENEX in malignant cell proliferation in diffuse large B-cell lymphoma (DLBCL). 22 DLBCL patients (6 newly diagnosed cases, 7 cases at complete remission, and 9 relapsed cases) were included in the study. Our results indicated that both SENEX gene and protein were significantly increased in peripheral blood mononuclear cells (PBMCs) and tumor cells of relapsed DLBCL patients, accompanied by overexpression of p21, p16, and phosphorylated retinoblastoma (Rb). Silencing the SENEX gene in a DLBCL cell line caused a significant decrease in cell proliferation and inhibited cell cycle progression in the G1… More >

Haisheng Yu¹, Heng Qi¹, Keqiu Li¹, Jianhui Zhang¹,Peng Xiao², Xun Wang¹

Computer Systems Science and Engineering, Vol.33, No.4, pp. 251-258, 2018, DOI:10.32604/csse.2018.33.251

Abstract The routing mechanism in Data Center networks can affect network performance and latency significantly. Hash-based method, such as ECMP (Equal-Cost Multi-Path), has been widely used in Data Center networks to fulfill the requirement of load balance. However, ECMP statically maps one flow to a path by a hash method, which results in some paths overloaded while others remain underutilized. Some dynamic flow scheduling schemes choose the most underutilized link as the next hop to better utilize the network bandwidth, while these schemes lacks of utilizing the global state of the network. To achieve high bandwidth utilization and low latency, we… More >