Manish Kuchakulla^1,2,*, Hriday P. Bhambhvani^1,2, Robert Fisch^1,2, Runzhuo Ma^1,2, Jonathan Gal², Marc Goldstein²

Canadian Journal of Urology, Vol.33, No.2, pp. 441-449, 2026, DOI:10.32604/cju.2025.071275 - 20 April 2026

Abstract Objectives: Men with obstructive azoospermia (OA) or infertility often require surgical sperm retrieval for assisted reproductive techniques. While sperm can be successfully obtained from either the testis or epididymis in these patients, sperm DNA integrity may differ between retrieval sites, which could influence reproductive outcomes. This study aimed to determine whether bilateral epididymal and/or testicular sperm extraction is necessary in men with OA or infertility and elevated DNA fragmentation index (DFI). Methods: We retrospectively analyzed men who underwent bilateral testicular biopsy and/or microscopic epididymal sperm aspiration (MESA) by a single surgeon from 2020–2022. TUNEL assays… More >

ZEINAB KLAAB¹, AZIZA HASSAN², JAWAHER ALBAQAMI¹, FAIZAH A. ALMALKI^1,*

BIOCELL, Vol.47, No.4, pp. 891-904, 2023, DOI:10.32604/biocell.2023.026556 - 08 March 2023

Abstract Cancer remains to be one of the most severe sicknesses globally. Cases have kept rising over the years. Breast cancer (BC), which is among the leading types of cancers and predominantly affects women, is the second leading cause of cancer mortality. Researchers have developed interventions over the years; however, the BC survival rate has not improved since the 1980s. This has created the need for novel drug interventions that would manage and treat BC more effectively. This study focused on using a combination of natural product extracts such as phytoestrogen (Ziziphus jujube) and Tannin nanoparticles (NP99)… More >

Imam O. Sherif¹, Mohammed M. H. Al-Gayyar^1,2

European Cytokine Network, Vol.24, No.3, pp. 114-121, 2013, DOI:10.1684/ecn.2013.0341

Abstract Purpose: Sodium nitrite, a food additive that is used as a color fixative and preservative for meats and fish, has been reported to have adverse health effects due to increased oxidative stress that could be harmful to different organs including the liver. Meanwhile, silymarin protects against hepatotoxicity caused by a variety of agents, on account of its antioxidative and anti-inflammatory effects. We therefore examined the impact of dietary silymarin on sodium nitrite-induced liver damage in rats. Methods: Fifty adult male Sprague-Dawley rats received 80 mg/kg sodium nitrite in the presence or absence of silymarin (10… More >

Vanessa Almendro, Neus Carbó, Sílvia Busquets, Maite Figueras, Luciana Tessitore^*, Francisco J. López-Soriano, Josep M. Argilés

European Cytokine Network, Vol.14, No.4, pp. 256-259, 2003

Abstract Recent studies have demonstrated the activation of skeletal muscle DNA fragmentation in some catabolic conditions [1]. In an attempt to elucidate if sepsis (a catabolic state) was also associated with muscle apoptosis, sepsis was induced by cecal ligation and puncture, and the results clearly show an induction of DNA fragmentation in gastrocnemius muscle following the induction of the septic state. Administration of rolipram (an inhibitor of tumour necrosis factor-a (TNF-α) synthesis) to septic rats clearly prevented the increased DNA fragmentation, suggesting that TNF-α is involved in the activation of the apoptotic events in septic rat More >