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Sepsis induces DNA fragmentation in rat skeletal muscle
Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain, and DISCAFF, Universita Piemonte Orientale ‘‘A. Avogadro’’, Novara, Italy.
* Corresponding Author: Josep M. Argilés,
European Cytokine Network 2003, 14(4), 256-259.
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Recent studies have demonstrated the activation of skeletal muscle DNA fragmentation in some catabolic conditions [1]. In an attempt to elucidate if sepsis (a catabolic state) was also associated with muscle apoptosis, sepsis was induced by cecal ligation and puncture, and the results clearly show an induction of DNA fragmentation in gastrocnemius muscle following the induction of the septic state. Administration of rolipram (an inhibitor of tumour necrosis factor-a (TNF-α) synthesis) to septic rats clearly prevented the increased DNA fragmentation, suggesting that TNF-α is involved in the activation of the apoptotic events in septic rat skeletal muscle.Keywords
sepsis; cecal ligation; skeletal muscle; DNA fragmentation; TNF-α; apoptosis
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APA Style
Almendro, V., Carbó, N., Busquets, S., Figueras, M., Tessitore, L. et al. (2003). Sepsis induces DNA fragmentation in rat skeletal muscle. European Cytokine Network, 14(4), 256–259.
Vancouver Style
Almendro V, Carbó N, Busquets S, Figueras M, Tessitore L, López-Soriano FJ, et al. Sepsis induces DNA fragmentation in rat skeletal muscle. Eur Cytokine Network. 2003;14(4):256–259.
IEEE Style
V. Almendro et al., “Sepsis induces DNA fragmentation in rat skeletal muscle,” Eur. Cytokine Network, vol. 14, no. 4, pp. 256–259, 2003.
Copyright © 2003 The Author(s). Published by Tech Science Press.This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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