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  • Open Access

    ARTICLE

    Fang-Xia-Dihuang decoction inhibits breast cancer progression induced by psychological stress via down-regulation of PI3K/AKT and JAK2/STAT3 pathways: An in vivo and a network pharmacology assessment

    LINGYAN LV1,2,#, JING ZHAO1,2,#, XUAN WANG1,2, LIUYAN XU1,2, YINGYI FAN2, CHUNHUI WANG3, HONGQIAO FAN4,5,*, XIAOHUA PEI5,*

    BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742

    Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions between main compounds and hub… More >

  • Open Access

    REVIEW

    Ketone bodies and inflammation modulation: A mini-review on ketogenic diet’s potential mechanisms in mood disorders

    YAN ZHENG1,2, SIHUI MA3,4,*, KATSUHIKO SUZUKI4, HISANORI KATO3, HUIJUAN JIA3,*

    BIOCELL, Vol.47, No.8, pp. 1897-1906, 2023, DOI:10.32604/biocell.2023.027632

    Abstract Mental disorders such as depression and anxiety inflict significant burdens on individuals and society. Commonly prescribed treatments often involve cognitive therapy and medications. However, for patients resistant to these conventional methods, alternative therapies like the Ketogenic Diet (KD) offer a promising avenue. KD and its key metabolite, β-hydroxybutyrate (BHB), have been hypothesized to alleviate mental disorders through anti-inflammatory actions, a crucial pathway in the pathophysiology of depression. This mini-review examines 15 clinical trials exploring the influence of KD and BHB on inflammation and their potential roles in managing mental disorders. Both human and animal studies were scrutinized to elucidate possible… More >

  • Open Access

    REVIEW

    Meaning in Life and Mental Health Issues in Older Adults: A Meta-Analysis

    Shu Nie1, Jiyoon Lim2, Xintian Xu3, Lei Zheng4, Yiqun Gan2,*

    International Journal of Mental Health Promotion, Vol.25, No.9, pp. 971-984, 2023, DOI:10.32604/ijmhp.2023.029155

    Abstract This study aims to be the first to use meta-analysis to explore the relationship between meaning in life (MIL) and mental health issues among older adults. A meta-analysis was conducted using six databases, resulting in 16 studies with 5,074 participants in total. The “metacor” and “forestplot” packages in R-Studio were used for data analysis. The total effect was calculated using a random-effects model, with I² = 86% in the heterogeneity test. The results showed a moderate negative correlation between MIL and mental health issues among older adults, with an average effect of −0.37. Five potential moderating variables were examined: the… More >

  • Open Access

    ARTICLE

    Cross-Lagged Relationship between Physical Activity Time, Openness and Depression Symptoms among Adolescents: Evidence from China

    Xiaojie Cao1, Qinyu Zhang2, Xinqiao Liu3,*

    International Journal of Mental Health Promotion, Vol.25, No.9, pp. 1009-1018, 2023, DOI:10.32604/ijmhp.2023.029365

    Abstract The relationship between physical activity time, openness and depression symptoms among adolescents is a cutting-edge research direction in the field, yet it remains unclear. This study is based on a sample of 7924 students from a nationally representative China Education Panel Survey database and examines the bidirectional relationships between physical activity time, openness and depression symptoms among Chinese adolescents. Descriptive analysis showed that during the 7th and 8th grades, the average physical activity time decreased to less than one hour per day, accompanied by a decreasing trend in openness and a slight worsening in depression symptoms. Correlation analysis showed a… More >

  • Open Access

    ARTICLE

    Examination of the Illness Representations among Children with T1DM in Relation to Mental Health Factors

    Brigitta Munkácsi1,*, Enikő Felszeghy1, Flóra Kenyhercz2, Beáta Erika Nagy1

    International Journal of Mental Health Promotion, Vol.25, No.8, pp. 961-969, 2023, DOI:10.32604/ijmhp.2023.027319

    Abstract The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus (T1DM) are depression, anxiety and behavioral disorders. Patients with comorbid psychopathology are less capable of psychically adjusting to the new life situation resulting from T1DM, which may negatively affect glycemic control and adherence related to the treatment. We aimed to investigate the association between mental health and type 1 diabetes including illness representation. 115 children and adolescents with T1DM were recruited through the outpatient clinic in Debrecen, Hungary. Measures: PRISM-D, Child Depression Inventory (CDI), Cantril Ladder and Self-Rated Health, Glycosylaeted haemoglobin (HbA1C) were measured. Children having depressive… More > Graphic Abstract

    Examination of the Illness Representations among Children with T1DM in Relation to Mental Health Factors

  • Open Access

    ARTICLE

    Study on the Relationship between Mental Health Literacy and Psychological Symptoms of University Students: Mediating Effect of Grit

    Yeo-Won Jeong1, Jung-Ha Kim2,*, Hyun-Kyeong Park3

    International Journal of Mental Health Promotion, Vol.25, No.7, pp. 813-821, 2023, DOI:10.32604/ijmhp.2023.027383

    Abstract Background: The occurrence of mental health symptoms is higher in individuals aged between 18 and 24 years than in other age groups. Mental health literacy is derived from health literacy, and focuses on the knowledge, attitudes, and competencies that individuals need to acquire to manage their own health effectively. Low mental health literacy is associated with poorer mental health. Grit is also a known protective factor against mental disorders. Despite a heightened focus on mental health literacy and grit as important factors for decreasing mental health symptoms, knowledge of the effect of mental health literacy and grit on mental health… More >

  • Open Access

    ARTICLE

    Mindfulness Meditation for Oncology Patients: Adapting Practice in Times of Pandemic

    Méditation de pleine conscience pour les patients en oncologie : adapter la pratique en temps de pandémie

    A. Couillet, B. Mastroianni, J. Hailloud, M.-P. Le Bris, G. Chvetzoff

    Psycho-Oncologie, Vol.16, No.1, pp. 182-191, 2022, DOI:10.3166/pson-2022-0183

    Abstract Meditation workshops were offered to patients, and we observed their feasibility during their oncology care. They were adapted to Covid-19: one session face-to-face, the second by videoconference. Data were analyzed retrospectively. A mixed analysis was carried out: the quantitative part evaluated the participation in the workshops, the characteristics of the patients, and the impact of the workshops. The qualitative part focused on the appropriation of this tool by the patients. Concerning feasibility, 66.7% of patients completed the program without differences between face-to-face and videoconference groups. We find an improvement in mindfulness skills, a decrease in anxiety and physical pain, and… More >

  • Open Access

    ARTICLE

    Associated Factors with Anxiety and Depression Symptoms in Tunisian Women Affected by Breast Cancer

    Facteurs associés à la symptomatologie anxiodépressive chez des femmes tunisiennes atteintes d’un cancer du sein

    M. Karoui, R. Kamoun, H. Nefzi, N. Marrakchi, H. Raies, A. Mezlini, K. Meddeb, F. Ellouze

    Psycho-Oncologie, Vol.17, No.1, pp. 31-37, 2023, DOI:10.3166/pson-2022-0211

    Abstract Aim: The objective of this study is to investigate the prevalence of depression and anxiety in women Tunisian population followed for breast cancer and to identify the socio-demographic, clinical, and of couple relationship factors associated with them.
    Procedure: Cross-sectional study on 100 patients followed for confirmed breast cancer. A questionnaire on the sociodemographic, clinical, therapeutic, conjugal, and sexual characteristics of the couple was completed. The HADS (Hospital Anxiety and Depression Scale) was used for the detection of anxiety and depressive symptoms.
    Results: A clinical score was found in 48% of cases for anxiety and 37% of cases for depression. Patients… More >

  • Open Access

    ARTICLE

    Exercise, Depression, and Anxiety in Young People: A Cross-Sectional Survey

    Meilin Huo1,*, Zhen Yang2

    International Journal of Mental Health Promotion, Vol.25, No.4, pp. 551-562, 2023, DOI:10.32604/ijmhp.2023.023406

    Abstract Background: Depression and anxiety are highly prevalent among adolescents and have multiple negative effects on their physical and mental health. While exercise can reduce the symptoms of depression and anxiety, the relationship between mental disorders among American university students has been rarely reported. Accordingly, this study aimed to explore the association between exercise, depression and anxiety among American university students in the 2018–2019 academic year. Methods: In this cross-sectional study, the association between exercise, depression and anxiety was investigated in a large representative sample of American university students. In the 2018–2019 academic year, university students aged 18+ years old from… More >

  • Open Access

    ARTICLE

    Short-Term Mindfulness Intervention on Adolescents’ Negative Emotion under Global Pandemic

    Yue Yuan1,*, Aibao Zhou1,*, Tinghao Tang1, Manying Kang2, Haiyan Zhao1, Zhi Wang3

    International Journal of Mental Health Promotion, Vol.25, No.4, pp. 563-577, 2023, DOI:10.32604/ijmhp.2023.022161

    Abstract Objective: In this research, we tried to explore how short-term mindfulness (STM) intervention affects adolescents’ anxiety, depression, and negative and positive emotion during the COVID-19 pandemic. Design: 10 classes were divided into experiment groups (5 classes; n = 238) and control (5 classes; n = 244) randomly. Hospital Anxiety and Depression Scale (HADS) and Positive and Negative Affect Schedule (PANAS) were used to measure participants’ dependent variables. In the experiment group, we conducted STM practice interventions every morning in their first class from March to November 2020. No interventions were conducted in the control group. Methods: Paired-sample t-tests were used to identify if a… More >

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