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Ketone bodies and inflammation modulation: A mini-review on ketogenic diet’s potential mechanisms in mood disorders

YAN ZHENG1,2, SIHUI MA3,4,*, KATSUHIKO SUZUKI4, HISANORI KATO3, HUIJUAN JIA3,*

1 College of Physical Education, Jilin University, Changchun, 130012, China
2 China Japan Union Hospital, Jilin University, Changchun, 130012, China
3 Health Nutrition, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1130032, Japan
4 Faculty of Sport Sciences, Waseda University, Tokorozawa, 3591192, Japan

* Corresponding Authors: SIHUI MA. Email: email; HUIJUAN JIA. Email: email-tokyo.ac.jp

(This article belongs to the Special Issue: Neuroimmune Interactions at the Crossroads of Health and Disease)

BIOCELL 2023, 47(8), 1897-1906. https://doi.org/10.32604/biocell.2023.027632

Abstract

Mental disorders such as depression and anxiety inflict significant burdens on individuals and society. Commonly prescribed treatments often involve cognitive therapy and medications. However, for patients resistant to these conventional methods, alternative therapies like the Ketogenic Diet (KD) offer a promising avenue. KD and its key metabolite, β-hydroxybutyrate (BHB), have been hypothesized to alleviate mental disorders through anti-inflammatory actions, a crucial pathway in the pathophysiology of depression. This mini-review examines 15 clinical trials exploring the influence of KD and BHB on inflammation and their potential roles in managing mental disorders. Both human and animal studies were scrutinized to elucidate possible cellular and molecular mechanisms. Out of the 15 trials, 10 reported reduced levels of at least one inflammatory mediator or mRNA post KD or BHB treatment, while two observed an elevation in anti-inflammatory agents. These findings suggest that KD and BHB could modulate cellular inflammatory pathways, highlighting their potential for therapeutic application in mental disorders.

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APA Style
ZHENG, Y., MA, S., SUZUKI, K., KATO, H., JIA, H. (2023). Ketone bodies and inflammation modulation: A mini-review on ketogenic diet’s potential mechanisms in mood disorders. BIOCELL, 47(8), 1897-1906. https://doi.org/10.32604/biocell.2023.027632
Vancouver Style
ZHENG Y, MA S, SUZUKI K, KATO H, JIA H. Ketone bodies and inflammation modulation: A mini-review on ketogenic diet’s potential mechanisms in mood disorders. BIOCELL . 2023;47(8):1897-1906 https://doi.org/10.32604/biocell.2023.027632
IEEE Style
Y. ZHENG, S. MA, K. SUZUKI, H. KATO, and H. JIA "Ketone bodies and inflammation modulation: A mini-review on ketogenic diet’s potential mechanisms in mood disorders," BIOCELL , vol. 47, no. 8, pp. 1897-1906. 2023. https://doi.org/10.32604/biocell.2023.027632



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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