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  • Open Access

    ARTICLE

    Dihydroartemisinin enhances cell apoptosis in diffuse large B cell lymphoma by inhibiting the STAT3 activity

    ZHENG CAO1,#, CHUNXIAO ZHOU1,#, ZHIMIN WU1, CHUNYAN WU1, WEN ZHANG1, SHILV CHEN1, XINDONG ZHAO1, SHAOLING WU2,*

    BIOCELL, Vol.47, No.5, pp. 1075-1083, 2023, DOI:10.32604/biocell.2023.027027 - 10 April 2023

    Abstract Background: Dihydroartemisinin (DHA) is reported to be a potential anticancer agent, and the mechanisms underlying the effects of DHA on diffuse large B cell lymphoma however are still obscure. This study aimed to assess the antitumor effect of DHA on diffuse large B cell lymphoma cells and to determine the potential underlying mechanisms of DHA-induced cell apoptosis. Methods: Here, the Cell Counting Kit 8 assay was conducted to study cell proliferation. We performed Annexin V-FITC/propidium iodide staining, real-time polymerase chain reaction, and western blot analysis to analyze cell apoptosis and potential molecular mechanisms. Results: The results showed More >

  • Open Access

    RESIDENT’S CORNER

    Diffuse large B cell lymphoma of the spermatic cord: a case report and literature review

    Shivam Joshi, Ahmed M. Mansour, Ahmed Eldefrawy, Mark S. Soloway

    Canadian Journal of Urology, Vol.19, No.6, pp. 6581-6583, 2012

    Abstract Primary lymphoma of the spermatic cord is rare. We report a case of primary lymphoma of the spermatic cord and review the literature. A 77-year-old man presented with a 5 month history of an enlarging right inguino-scrotal mass. On physical exam, the mass involved the spermatic cord. Computerized tomography and magnetic resonance imaging revealed a 10 cm x 4 cm inguinoscrotal mass related to the spermatic cord. A right inguinal orchidectomy with wide local excision was performed. Pathological and immunohistochemical evaluation identified the tumor as a diffuse large B cell lymphoma of the spermatic cord. More >

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