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Dihydroartemisinin enhances cell apoptosis in diffuse large B cell lymphoma by inhibiting the STAT3 activity

ZHENG CAO1,#, CHUNXIAO ZHOU1,#, ZHIMIN WU1, CHUNYAN WU1, WEN ZHANG1, SHILV CHEN1, XINDONG ZHAO1, SHAOLING WU2,*

1 Qingdao University, Qingdao, 266000, China
2 Department of Hematology, The Affiliated Hospital, Qingdao University, Qingdao, 266000, China

* Corresponding Author: SHAOLING WU. Email: email
# These authors contributed to the work equally and should be regarded as co-first authors

BIOCELL 2023, 47(5), 1075-1083. https://doi.org/10.32604/biocell.2023.027027

Abstract

Background: Dihydroartemisinin (DHA) is reported to be a potential anticancer agent, and the mechanisms underlying the effects of DHA on diffuse large B cell lymphoma however are still obscure. This study aimed to assess the antitumor effect of DHA on diffuse large B cell lymphoma cells and to determine the potential underlying mechanisms of DHA-induced cell apoptosis. Methods: Here, the Cell Counting Kit 8 assay was conducted to study cell proliferation. We performed Annexin V-FITC/propidium iodide staining, real-time polymerase chain reaction, and western blot analysis to analyze cell apoptosis and potential molecular mechanisms. Results: The results showed that DHA substantially suppressed cell proliferation and induced cell apoptosis in vitro in a time- and concentration-dependent fashion. Moreover, STAT3 activity could be inhibited after stimulation with DHA. Conclusion: These results imply that the underlying anti-tumoral effect of DHA may increase apoptosis in diffuse large B cell lymphoma cells via the STAT3 signaling pathway. In addition, DHA might be an effective drug for diffuse large B cell lymphoma therapy.

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APA Style
CAO, Z., ZHOU, C., WU, Z., WU, C., ZHANG, W. et al. (2023). Dihydroartemisinin enhances cell apoptosis in diffuse large B cell lymphoma by inhibiting the STAT3 activity. BIOCELL, 47(5), 1075-1083. https://doi.org/10.32604/biocell.2023.027027
Vancouver Style
CAO Z, ZHOU C, WU Z, WU C, ZHANG W, CHEN S, et al. Dihydroartemisinin enhances cell apoptosis in diffuse large B cell lymphoma by inhibiting the STAT3 activity. BIOCELL . 2023;47(5):1075-1083 https://doi.org/10.32604/biocell.2023.027027
IEEE Style
Z. CAO et al., "Dihydroartemisinin enhances cell apoptosis in diffuse large B cell lymphoma by inhibiting the STAT3 activity," BIOCELL , vol. 47, no. 5, pp. 1075-1083. 2023. https://doi.org/10.32604/biocell.2023.027027



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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