EJDER SAYLAV BORA1,*, MüMIN ALPER ERDOĞAN2, BAHATTIN ÖZKUL3, İBRAHIM HALIL SEVER4,
İBRAHIM SÖĞÜT5, CANAN HÜRDAĞ6, OYTUN ERBAŞ7
BIOCELL, Vol.46, No.2, pp. 433-439, 2022, DOI:10.32604/biocell.2022.018510
Abstract Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known anti-inflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in acute lung injury (ALI). Method: 28 wistar albino rats were divided into 4 groups. Sepsis model is performed by the feces intraperitoneal-injection procedure (FIP). Results: TNF-a, CRP, IL-6, IL 1-Beta, lactic acid, and MDA values were significantly decreased in the FIP+digitoxin group compared to the FIP+Saline group. When the same groups were examined, histological improvements such as… More >
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