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Short term protective effect of digitoxin in sepsis-induced acute lung injury

EJDER SAYLAV BORA1,*, MüMIN ALPER ERDOĞAN2, BAHATTIN ÖZKUL3, İBRAHIM HALIL SEVER4, İBRAHIM SÖĞÜT5, CANAN HÜRDAĞ6, OYTUN ERBAŞ7
1 İzmir Atatürk Research and Training Hospital Emergency Medicine, Izmir, Turkey
2 Department of Physiology, İzmir Katip Çelebi University, Izmir, Turkey
3 Department of Radiology, Istanbul Atlas University, Istanbul, Turkey
4 Department of Radiology, Demiroğlu Bilim University, Istanbul, Turkey
5 Department of Biochemistry, Demiroğlu Bilim University, Istanbul, Turkey
6 Department of Histology and Embryology, Demiroğlu Bilim University, Istanbul, Turkey
7 Department of Physiology, Demiroğlu Bilim University, Istanbul, Turkey
* Corresponding Author: EJDER SAYLAV BORA. Email:

BIOCELL 2022, 46(2), 433-439. https://doi.org/10.32604/biocell.2022.018510

Received 31 July 2021; Accepted 08 September 2021; Issue published 20 October 2021

Abstract

Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known anti-inflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in acute lung injury (ALI). Method: 28 wistar albino rats were divided into 4 groups. Sepsis model is performed by the feces intraperitoneal-injection procedure (FIP). Results: TNF-a, CRP, IL-6, IL 1-Beta, lactic acid, and MDA values were significantly decreased in the FIP+digitoxin group compared to the FIP+Saline group. When the same groups were examined, histological improvements such as decrease in alveolar inflammation and decrease in septal thickening in the digitoxin group and thorax CT were found to be significantly higher in the Hounsfield unit digitoxin group compared to the Saline group. Conclusion: Digitoxin has shown biochemical improvement in sepsis with all known mechanisms of action, and healing effects in both computerized tomography and histology in the lung.

Keywords

Digitoxin; Animal model; Sepsis; Acute lung injury

Cite This Article

BORA, E. S., ERDOĞAN, M. A., ÖZKUL, B., SEVER, I. H., SÖĞÜT, I., HÜRDAĞ, C.,ERBAŞ, O. (2022). Short term protective effect of digitoxin in sepsis-induced acute lung injury. BIOCELL, 46(2), 433-439.

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This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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