Ji SHI; Peixin SUN, Ye ZHANG, Bing YAO, Haozhe PIAO

BIOCELL, Vol.43, No.3, pp. 119-128, 2019, DOI:10.32604/biocell.2019.07577

Abstract Glioma is the most common primary malignant brain tumor with a poor survival rate. In recent years, no significant progress has been made in the treatment of gliomas in contrast to the development of improved diagnosis via molecular typing. Newcastle disease virus (NDV), a negative-stranded RNA virus that exhibits oncolytic activity, has been investigated for its capacity to elicit antitumor activity in many types of cancers, including glioma. Therefore, application of oncolytic viruses, such as NDV, as a new treatment strategy to specifically target aberrant signaling in glioblastomas has brought new hope. For many years, NDV has been investigated for… More >

Zongqiang GAO¹, Xiong GUO², Junchang CHEN¹, Chen DUAN²

BIOCELL, Vol.43, No.2, pp. 99-102, 2019, DOI:10.32604/biocell.2019.06520

Abstract This study aimed to investigate the effect of hyaluronic acid (HA) on the expression of heat shock protein 70 (HSP70) in chondrocytes isolated from patients with osteoarthritis (OA) and Kashin-Beck disease (KBD). The chondrocytes were collected from OA and KBD patients, and chondrocytes isolated from patients of accident injuries were used as the control. The chondrocytes were treated with HA at different doses. HSP70 expression in chondrocytes at both mRNA and protein levels was tested by PCR and Western blot analysis. Compared with control, both mRNA and protein levels of HSP70 were higher in chondrocytes from KBD and OA. However,… More >

S. Kobayashi¹, J. Ji¹, H. Morikawa¹, D. Tang², D. N. Ku³

The International Conference on Computational & Experimental Engineering and Sciences, Vol.6, No.3, pp. 169-174, 2008, DOI:10.3970/icces.2008.006.169

Abstract The increase of the blood velocity in the distal side of the stenosis causes negative transmural pressure, and atheroscrerotic plaque is compressed, furthermore, the stenosis may cause the collpase which leads the rupture of the plaque. The resultant compression may be important in the development of atherosclerotic plaque fracture and subsequent thrombosis or distal embolization. We have developed stenosis models made of polyvinyl alcohol hydrogel, which closely approximate an arterial disease situation, and performed pulsatile flow experiments. Valsalva's maneuver and cough cause a sharp rise in jugular venous pressure to greater than 50 mmHg. Such transient pressure increases within the… More >

U.Suryanarayana Murty¹, V.Sreehari Rao²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.5, No.2, pp. 121-128, 2008, DOI:10.3970/icces.2008.005.121

Abstract Artificial intelligence has opened a new window of opportunity and has definitely a long way to look ahead in\nobreakspace {}area of data analysis. The enormity of magnitude of data and its complex nature often perplex the epidemiologists. This is especially true in case of vector borne diseases where a timely and precise understanding of disease during decision making process comes handy for curbing the diseases in event of an outbreak or epidemic. Often the public health officials feel the need of correct identification of true positive cases. A tool that classify disease according to presence or absence of a disease… More >

Dalin Tang¹, Chun Yang², Pedro N. del Nido³, Tal Geva³, Chun Yuan⁴, Tom Hatsukami⁵, Fei Liu⁴, Jie Zheng⁶, Pamela K. Woodard⁶

The International Conference on Computational & Experimental Engineering and Sciences, Vol.1, No.1, pp. 1-6, 2007, DOI:10.3970/icces.2007.001.001

Abstract Image-based computational models for blood flow in the heart and diseased arteries have been developed for disease assessment and potential clinical applications. Models with fluid-structure interactions for human right ventricle (RV) remodeling surgery design, carotid and coronary atherosclerotic plaques and abdominal aortic aneurysm (AAA) were presented. Organ morphology, material properties, governing equations, proper initial and boundary conditions, controlling factors and research focuses for each model were discussed. More >

T. Yamaguchi¹, T. Ishikawa², Y. Imai²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.2, pp. 79-80, 2009, DOI:10.3970/icces.2009.009.079

Abstract Human cardiovascular system is always under the integrated nervous and humoral control of the whole body, i.e. in homeostasis. Multiple feedback mechanisms with mutual interactions among systems, organs, and even tissues provide integrated control of the entire body. These control mechanisms have different spatial coverages, from the micro- to macroscale, and different time constants, from nanoseconds to decades. We think that these variations in spatial as well as temporal scales should be taken into account in discussing phenomena in the cardiovascular system.
In this background,we have been investigatingthe cardiovascular system over micro to macro levels by using conjugated computational mechanics… More >

Pinjie Xu², Ce Li^1,2,*, Liguo Zhang^3,4, Feng Yang^1,2, Jing Zheng^1,5, Jingwu Feng²

Journal on Artificial Intelligence, Vol.1, No.1, pp. 9-18, 2019, DOI:10.32604/jai.2019.06157

Abstract Detecting the underground disease is very crucial for the roadbed health monitoring and maintenance of transport facilities, since it is very closely related to the structural health and reliability with the rapid development of road traffic. Ground penetrating radar (GPR) is widely used to detect road and underground diseases. However, it is still a challenging task due to data access anywhere, transmission security and data processing on cloud. Cloud computing can provide scalable and powerful technologies for large-scale storage, processing and dissemination of GPR data. Combined with cloud computing and radar detection technology, it is possible to locate the underground… More >

Sara Salehyar^{1, †}, Nickolas Forsch^1,†,*, Kathleen Gilbert^2,3, Alistair A. Young^3,4, James C. Perry⁵, Sanjeet Hegde⁵, Jeffrey H. Omens^1,6, Andrew D. McCulloch^1,6

Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 179-183, 2019, DOI:10.32604/mcb.2019.07384

Abstract Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. Infants diagnosed with TOF require surgical interventions to survive into adulthood. However, as a result of postoperative structural malformations and long-term ventricular remodeling, further interventions are often required later in life. To help identify those at risk of disease progression, serial cardiac magnetic resonance (CMR) imaging is used to monitor these patients. However, most of the detailed information on cardiac shape and biomechanics contained in these large four-dimensional (4D) data sets goes unused in clinical practice for lack of efficient and comprehensive quantitative analysis tools. While… More >

Shu Q. Liu^∗,†, Brandon J. Teft^*, Li-Qun Zhang^‡, Yan Chun Li^§, Yu H. Wu^*

Molecular & Cellular Biomechanics, Vol.7, No.2, pp. 59-76, 2010, DOI:10.3970/mcb.2010.007.059

Abstract The activities of vascular cells, including adhesion, proliferation, and migration, are mediated by extracellular matrix components, including collagen matrix and elastic fibers or laminae. Whereas the collagen matrix stimulates vascular cell adhesion, proliferation, and migration, the elastic laminae inhibit these activities. Coordinated regulation of cell activities by these matrix components is an essential process for controlling the development and remodeling of the vascular system. This article summarizes recent development on the role of arterial elastic laminae in regulating the development of smooth muscle-like cells from bone marrow-derived progenitor cells as well as in mediating cell adhesion, proliferation, and migration with… More >

Dalin Tang^*, Chun Yang^†, Tal Geva^‡,§, Pedro J. del Nido^¶

Molecular & Cellular Biomechanics, Vol.4, No.3, pp. 159-176, 2007, DOI:10.3970/mcb.2007.004.159

Abstract A single-layer isotropic patient-specific right/left ventricle and patch (RV/LV/Patch) combination model with fluid-structure interactions (FSI) was introduced in our previous papers to evaluate and optimize human pulmonary valve replacement/insertion (PVR) surgical procedure and patch design. In this paper, an active anisotropic model with two-layer structure for ventricle wall and tissue fiber orientation was introduced to improve previous isotropic model for more accurate assessment of RV function and potential application in PVR surgery and patch design. A material-stiffening approach was used to model active heart contraction. The computational models were used to conduct ``virtual (computational)'' surgeries and test the hypothesis that… More >