Vaskar Chakma^1,*, Md Jaheid Hasan Nerab¹, Abdur Rouf¹, Abu Sayed², Hossem Md Saim³, Md. Nournabi Khan³

Journal of Intelligent Medicine and Healthcare, Vol.4, pp. 1-35, 2026, DOI:10.32604/jimh.2026.074347 - 23 January 2026

Abstract Smoking continues to be a major preventable cause of death worldwide, affecting millions through damage to the heart, metabolism, liver, and kidneys. However, current medical screening methods often miss the early warning signs of smoking-related health problems, leading to late-stage diagnoses when treatment options become limited. This study presents a systematic comparative evaluation of machine learning approaches for smoking-related health risk assessment, emphasizing clinical interpretability and practical deployment over algorithmic innovation. We analyzed health screening data from 55,691 individuals, examining various health indicators including body measurements, blood tests, and demographic information. We tested three advanced… More >

SEUNGIL KIM, GUN-DONG KIM^*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.073781 - 23 January 2026

Abstract Neutrophil extracellular trap (NET) formation or NETosis is a specialized innate immune process in which neutrophils release chromatin fibers decorated with histones and antimicrobial proteins. Although pivotal for pathogen clearance, aberrant NETosis has emerged as a critical modulator of acute and chronic respiratory pathologies, including acute respiratory distress syndrome, asthma, and chronic obstructive pulmonary disease. Dysregulated NET release exacerbates airway inflammation by inducing epithelial injury, mucus hypersecretion, and the recruitment of inflammatory leukocytes, thereby accelerating tissue remodeling and functional decline. Mechanistically, NETosis is governed by peptidyl arginine deiminase 4 (PADI4)-mediated histone citrullination, NADPH oxidase-dependent reactive More >

Rasit Dinc¹, Nurittin Ardic^2,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072337 - 23 January 2026

Abstract Neutrophil extracellular traps (NETs) have emerged as key mediators of cardiovascular diseases (CVDs), linking innate immune activation to vascular injury, thrombosis, and maladaptive remodeling. This review synthesizes recent insights into the molecular and cellular pathways driving NET formation, including post-translational modifications, metabolic reprogramming, inflammasome signaling, and autophagy. It highlights the role of NETs in atherosclerosis, thrombosis, myocardial ischemia-reperfusion injury, and hypertension, emphasizing common control points such as peptidylarginine deiminase 4 (PAD4)-dependent histone citrullination and nicotinamide adenine dinucleotide phosphate oxidases 2 (NOX2)-mediated oxidative stress. Mechanistic interpretation of circulating biomarkers, including myeloperoxidase (MPO)-DNA complexes, citrullinated histone H3,… More >

JOSé A. BOGA^1,2, ANA COTO-MONTES^2,3,*, RUSSEL J. REITER⁴

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.068245 - 23 January 2026

Abstract Aerobic glycolysis, also known as the Warburg effect, and the accumulation of lactate that it causes, are increasingly recognized outside the field of oncology as triggers of chronic non-neoplastic disorders. This review integrates preclinical and clinical evidence to evaluate the ability of melatonin to reverse Warburg-effect-like metabolic reprogramming. Literature on neurodegeneration, age-related sarcopenia, type 2 diabetes, chronic kidney disease, heart failure and pulmonary arterial hypertension (PAH) has been reviewed and synthesised. In all of these conditions, hypoxia-inducible factor 1α (HIF-1α) and pyruvate dehydrogenase kinase 4 (PDK4) inhibit the pyruvate dehydrogenase complex. This diverts pyruvate away… More >

Zhuangqiang Wen¹, Min Zhang², Zhekun Shou^3,*

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071300 - 08 January 2026

Abstract Roadbed disease detection is essential for maintaining road functionality. Ground penetrating radar (GPR) enables non-destructive detection without drilling. However, current identification often relies on manual inspection, which requires extensive experience, suffers from low efficiency, and is highly subjective. As the results are presented as radar images, image processing methods can be applied for fast and objective identification. Deep learning-based approaches now offer a robust solution for automated roadbed disease detection. This study proposes an enhanced Faster Region-based Convolutional Neural Networks (R-CNN) framework integrating ResNet-50 as the backbone and two-dimensional discrete Fourier spectrum transformation (2D-DFT) for… More >

Mintao Xu^1,#, Zichao Jin^1,#, Yangyang Tian¹, Jingcheng Zhang^1,*, Huiqin Ma¹, Yujin Jing¹, Jiangxing Wu², Jing Zhai²

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 4059-4078, 2025, DOI:10.32604/phyton.2025.074422 - 29 December 2025

Abstract The frequent outbreaks of crop diseases pose a serious threat to global agricultural production and food security. Data-driven forecasting models have emerged as an effective approach to support early warning and management, yet the lack of user-friendly tools for model development remains a major bottleneck. This study presents the Multi-Scenario Crop Disease Forecasting Modeling System (MSDFS), an open-source platform that enables end-to-end model construction-from multi-source data ingestion and feature engineering to training, evaluation, and deployment-across four representative scenarios: static point-based, static grid-based, dynamic point-based, and dynamic grid-based. Unlike conventional frameworks, MSDFS emphasizes modeling flexibility, allowing… More >

Virna Margarita Martín Giménez¹, SebastiáN GarcíA MenéNdez^2,3, Luiz Gustavo A. Chuffa⁴, Vinicius Augusto SimãO⁴, Russel J. Reiter⁵, Ramaswamy Sharma⁶, Walter Balduini⁷, Carla Gentile⁸, Walter Manucha^2,3,*

BIOCELL, Vol.49, No.12, pp. 2245-2282, 2025, DOI:10.32604/biocell.2025.071830 - 24 December 2025

Abstract Neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) are characterized by progressive neuronal loss, which is closely linked to mitochondrial dysfunction. These pathologies involve a complex interplay of genetics, protein misfolding, and cellular stress, culminating in impaired energy metabolism, an increase in reactive oxygen species (ROS), and defective mitochondrial quality control. The accumulation of damaged mitochondria and dysregulation of pathways such as the Integrated Stress Response (ISR) are central to the pathogenesis of these conditions. This review explores the critical relationship between mitochondrial stress… More >

Zhe He¹, Yaning Zhang^2,*

International Journal of Mental Health Promotion, Vol.27, No.11, pp. 1747-1768, 2025, DOI:10.32604/ijmhp.2025.070491 - 28 November 2025

Abstract Background: Depression represents a significant global mental health burden, particularly among middle-aged and older Chinese with chronic diseases in high-altitude regions, where harsh environmental conditions and limited social support exacerbate mental health disparities. This paper aims to develop an interpretable machine learning prediction framework to identify the key factors of depression in this vulnerable population, thereby proposing targeted intervention measures. Methods: Utilizing data from the China Health and Retirement Longitudinal Study in 2020, this paper screened out and analyzed 2431 samples. Subsequently, Recursive Feature Elimination and Least Absolute Shrinkage and Selection Operator were applied to screen… More >

CHIOMA C. EZEUKO^#, SANDANI V. T. WIJERATHNE^#, QIANA L. MATTHEWS^*

BIOCELL, Vol.49, No.9, pp. 1605-1629, 2025, DOI:10.32604/biocell.2025.065474 - 25 September 2025

Abstract Extracellular vesicles (EVs) have arisen as potential therapeutic tools in managing infectious diseases because EVs can regulate cell-to-cell signaling, function as drug transport mechanisms, and influence immune reactions. They are obtained from a myriad of sources, such as plants, humans, and animal cells. EVs like exosomes and ectosomes can be utilized in their native form as therapeutics or engineered to encompass antimicrobials, vaccines, and oligonucleotides of interest with a targeted delivery strategy. An in-depth understanding of host-pathogen dynamics provides a solid foundation for exploiting its full potential in therapeutics against infectious diseases. This review mainly More >

Yifan Li^1,#, Xu Huang^2,#, Bingyu Ma³, Ling Sun¹, Shushui Wang¹, Zhiwei Zhang¹, Yumei Xie^1,*

Congenital Heart Disease, Vol.20, No.4, pp. 463-475, 2025, DOI:10.32604/chd.2025.068286 - 18 September 2025

Abstract Objective: The aim of the present study was to investigate long-term efficacy and safety of percutaneous stent implantation for residual pulmonary artery stenosis (PAS) in pediatric patients after surgical repair of complicated congenital heart diseases (CHDs). Methods: All pediatric patients diagnosed with residual PAS after surgical repair of complicated CHDs between 1996 and 2020 were retrospectively enrolled in the study. Results: A total of 41 patients (30 males, 11 females; median age 5.0 years, median weight 17 kg) were followed-up for a median of 7.1 years. Follow-up echocardiography results demonstrated that the target vessel diameter increased from… More >