SINEM GÖKÇE KÜTÜK1, MUSTAFA NAZIROĞLU2,3,*
BIOCELL, Vol.45, No.1, pp. 177-188, 2021, DOI:10.32604/biocell.2021.013531
Abstract A protective action of melatonin (MELAT) on docetaxel (DCT)-induced inflammation, apoptosis, and reactive free
oxygen radical (fROS) generation values via blocking of TRPM2 calcium-permeable channel was investigated in different cells
except for laryngo-tracheal epithelial (LT-Epi) cells. Hence, the protective action of MELAT on DCT-induced oxidative toxicity
and inflammation in LT-Epi tissue and cells of mice were investigated in the current study. MELAT treatment ameliorated DCTinduced mitochondrial ROS in the LT-Epi cells by reducing the generation of fROS (cytosolic and mitochondrial), lipid
peroxidation, and depolarization of the mitochondrial membrane, while increasing reduced glutathione (GSH), GSH
peroxidase, and total antioxidant status. In… More >
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