Ahmed Qasem^*

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 809-824, 2025, DOI:10.32604/phyton.2025.062683 - 31 March 2025

Abstract Pimpinella anisum, commonly known as anise, is generally used in both folk medicine and the culinary world. In traditional medicine, it is valued for its digestive, respiratory, and antispasmodic properties. This study aims to examine the volatile compounds and antibacterial effect of P. anisum essential oil (PAEO) as well as for the first time its genotoxicity employing both in vitro and computational approaches. Gas chromatography-mass spectrometry (GC-MS) analysis identified anethole as the principal compound, which comprises 92.47% of PAEO. PAEO was tested for its potential antibacterial properties against Bacillus subtilis ATCC 6633, Listeria innocua ATCC 33090, Staphylococcus aureus ATCC 29213, Klebsiella aerogenes… More >

LIN QIU^1,#, ANQI TAO^1,#, XIAOQIAN SUN^4,5, FEI LIU¹, XIANPENG GE^2,3,*, CUIYING LI^1,*

Oncology Research, Vol.31, No.5, pp. 715-752, 2023, DOI:10.32604/or.2023.029443 - 21 July 2023

Abstract We analyzed RNA-sequencing (RNA-seq) and clinical data from head and neck squamous cell carcinoma (HNSCC) patients in The Cancer Genome Atlas (TCGA) Genomic Data Commons (GDC) portal to investigate the prognostic value of anoikis-related genes (ARGs) in HNSCC and develop new targeted drugs. Differentially expressed ARGs were screened using bioinformatics methods; subsequently, a prognostic model including three ARGs (CDKN2A, BIRC5, and PLAU) was constructed. Our results showed that the model-based risk score was a good prognostic indicator, and the potential of the three ARGs in HNSCC prognosis was validated by the TISCH database, the model’s… More >

JONG HWAN SUNG^*

BIOCELL, Vol.46, No.5, pp. 1177-1180, 2022, DOI:10.32604/biocell.2022.019055 - 06 January 2022

Abstract Organ-on-a-chip technology aims to reproduce the key physiological features of human organs and tissues, even complex actions of multi-organ interaction. While organ-on-a-chips at single-organ level has made notable achievement during the last decade, multi-organ-on-a-chips, which manifests unique advantages, has started gathering attention only recently. In this viewpoint, we discuss the current status of organ-on-a-chip technology, with a specific emphasis on multi-organ-on-a-chip. Key technological advances contributing to the maturation of the field, and challenges that need to be addressed before wider adoption in relevant fields are discussed. We will share our perspectives on how the multi-organ-on-a-chip More >