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  • Open Access

    ARTICLE

    Evaluating the Effectiveness of Graph Convolutional Network for Detection of Healthcare Polypharmacy Side Effects

    Omer Nabeel Dara1,*, Tareq Abed Mohammed2, Abdullahi Abdu Ibrahim1

    Intelligent Automation & Soft Computing, Vol.39, No.6, pp. 1007-1033, 2024, DOI:10.32604/iasc.2024.058736 - 30 December 2024

    Abstract Healthcare polypharmacy is routinely used to treat numerous conditions; however, it often leads to unanticipated bad consequences owing to complicated medication interactions. This paper provides a graph convolutional network (GCN)-based model for identifying adverse effects in polypharmacy by integrating pharmaceutical data from electronic health records (EHR). The GCN framework analyzes the complicated links between drugs to forecast the possibility of harmful drug interactions. Experimental assessments reveal that the proposed GCN model surpasses existing machine learning approaches, reaching an accuracy (ACC) of 91%, an area under the receiver operating characteristic curve (AUC) of 0.88, and an More >

  • Open Access

    ARTICLE

    Spotted Hyena Optimizer Driven Deep Learning-Based Drug-Drug Interaction Prediction in Big Data Environment

    Mohammed Jasim Mohammed Jasim1, Shakir Fattah Kak2, Zainab Salih Ageed3, Subhi R. M. Zeebaree4,*

    Computer Systems Science and Engineering, Vol.46, No.3, pp. 3831-3845, 2023, DOI:10.32604/csse.2023.037580 - 03 April 2023

    Abstract Nowadays, smart healthcare and biomedical research have marked a substantial growth rate in terms of their presence in the literature, computational approaches, and discoveries, owing to which a massive quantity of experimental datasets was published and generated (Big Data) for describing and validating such novelties. Drug-drug interaction (DDI) significantly contributed to drug administration and development. It continues as the main obstacle in offering inexpensive and safe healthcare. It normally happens for patients with extensive medication, leading them to take many drugs simultaneously. DDI may cause side effects, either mild or severe health problems. This reduced… More >

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