Jie REN1, Qian LIANG2
BIOCELL, Vol.43, No.3, pp. 199-206, 2019, DOI: 10.32604/biocell.2019.07128
Abstract This study aimed to investigate the role of high mobility group box-1 (HMGB1) expression in oral squamous
cell carcinoma; HMGB1 promoted the proliferation and invasion of oral squamous cell carcinoma via activating
epithelial-mesenchymal transformation (EMT). In this study, RNA transfection was used to silence the expression of
HMGB1 in oral squamous cell carcinoma cells. CCK-8, cell clone formation and trans-well assays were used to detect
the proliferation and invasion of cells before and after HMGB1 silencing. qRT-PCR and Western blot were used to
detect changes in EMT marker protein expression before and after transfection. HMGB1 was significantly higher in
OSCC… More >
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