Ke Liu^1,2,3,#, Xia Xue^1,2,3,#, Haiming Qin^4,5,#, Jiaying Zhu^6,#, Meng Jin^1,6, Die Dai⁶, Youcai Tang¹, Ihtisham Bukhari¹, Hangfan Liu¹, Chunjing Qiu¹, Feifei Ren¹, Pengyuan Zheng^1,2,3, Yang Mi^1,2,3,*, Weihua Chen^6,7,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.072661 - 19 January 2026

Abstract Background: The gut microbiome has emerged as a critical modulator of cancer immunotherapy response. However, the mechanisms by which gut-associated metabolites influence checkpoint blockade efficacy in prostate cancer (PC) remain not fully explored. The study aimed to explore how gut metabolites regulate death-ligand 1 (PD-L1) blockade via exosomes and boost immune checkpoint inhibitors (ICIs) in PC. Methods: We recruited 70 PC patients to set up into five subgroups. The integrated multi-omics analysis was performed. In parallel, we validated the function of gut microbiome-associated metabolites on PD-L1 production and immunotherapy treatment efficacy in PC cell lines… More >

Ping Wang^1,2,#, Yan-Han Chen^1,2,#, Ze-Tao Zhan^1,2, Jun-Xiang Zeng^1,2, Yu Chen^3,4, Yuan Lin^1,2, Tao Chen^1,5,*, Wei-Jie Zhou^1,2,5,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071902 - 19 January 2026

Abstract Background: Thimerosal is a mercury-containing preservative widely used in vaccines. This study aimed to investigate its potential antitumor effects and mechanisms in solid malignancies, particularly colorectal cancer (CRC) and melanoma. Methods: A combination of in vitro and in vivo approaches was employed. Cell proliferation, apoptosis, migration, and invasion were assessed using Cell Counting Kit-8 (CCK-8), colony formation, ATP viability, Western blotting, flow cytometry, wound-healing and Transwell assays. Subcutaneous, lung metastases, and Azoxymethane/Dextran Sulfate Sodium Salt (AOM/DSS)-induced colitis-associated CRC models were established to examine antitumor efficacy and safety. The functional role of mercury ions was validated using structural… More >

Ruoxue Cai^1,#, Shuyi Hu^2,#, Feiyang Li², Huanhuan Sha^3,*, Guoren Zhou^2,*, Ying Fang³

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070893 - 19 January 2026

Abstract Objective: To determine whether immunotherapy can bring new hope for patients with limited-stage small-cell lung cancer (LS-SCLC). We conducted this retrospective study to evaluate whether immunotherapy can achieve better efficacy in LS-SCLC patients. Methods: We evaluated 122 LS-SCLC patients who received concurrent chemoradiotherapy (CCRT) or sequential chemoradiotherapy (SCRT) (Group A) and immunotherapy combined with CCRT/SCRT followed by immunotherapy (Group B), to assess the objective response rate (ORR), disease control rate (DCR), and progression-free survival (PFS). Factors affecting prognosis were also explored using Cox analysis. The prognosis of patients with type 2 diabetes and patients with… More >

José Armando Santas Ciavatta, Juan Ramón Bermejo Higuera^*, Javier Bermejo Higuera, Juan Antonio Sicilia Montalvo, Tomás Sureda Riera, Jesús Pérez Melero

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.074566 - 12 January 2026

Abstract As artificial Intelligence (AI) continues to expand exponentially, particularly with the emergence of generative pre-trained transformers (GPT) based on a transformer’s architecture, which has revolutionized data processing and enabled significant improvements in various applications. This document seeks to investigate the security vulnerabilities detection in the source code using a range of large language models (LLM). Our primary objective is to evaluate the effectiveness of Static Application Security Testing (SAST) by applying various techniques such as prompt persona, structure outputs and zero-shot. To the selection of the LLMs (CodeLlama 7B, DeepSeek coder 7B, Gemini 1.5 Flash,… More >

Jing Shan¹, Catherine King^2,3, Harunor Rashid^3,4, Veysel Kayser^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >

Hafida Khelafi¹, Wassima Lakhdari², Mustapha Mounir Bouhenna³, Said Boudeffeur⁴, Hayet Meamiche¹, Salah Neghmouche Nacer^5,*, Meriam Laouar⁶

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3975-3989, 2025, DOI:10.32604/phyton.2025.073210 - 29 December 2025

Abstract Essential oils (EOs) derived from medicinal plants are gaining recognition as sustainable alternatives to synthetic fungicides in the management of plant pathogens. This study investigates the chemical composition, chromatographic profile, and antifungal of Mentha rotundifolia essential oil against Fusarium oxysporum f. sp. albedinis (Foa), the pathogen responsible for Bayoud disease in date palm. The oil was extracted through hydrodistillation and characterized using thin-layer chromatography (TLC) and gas chromatography–mass spectrometry (GC-MS), revealing multiple fractions corresponding to terpenoid constituents and 23 chemical constituents, predominantly oxygenated monoterpenes (68.51%), with piperitenone oxide as the major component (62.53%). The antifungal efficacy was evaluated… More >

Xiaolong Li, Hui Chen, Yingwen Liu, Peng Yang^*

Frontiers in Heat and Mass Transfer, Vol.23, No.6, pp. 1767-1788, 2025, DOI:10.32604/fhmt.2025.070537 - 31 December 2025

Abstract Hazardous gas intrusion in tightly sealed and geometrically complex confined spaces, such as armored tanks, poses a critical threat to occupant health. The intricate internal structure of these systems may lead to non-intuitive pollutant transport pathways. However, the spatial and temporal evolution of these structures, as well as the intrinsic mechanisms of the purification systems, remain poorly elucidated. In this study, a high-fidelity, transient three-dimensional computational fluid dynamics (CFD) model was developed to simulate the leakage and dispersion of carbon monoxide (CO) and nitrogen dioxide (NO₂) using the RNG k-ε turbulence model. Scenarios with and without… More > Graphic Abstract

Zhenhong Wang^1,2, Hailong Wu^3,*

Journal of Psychology in Africa, Vol.35, No.6, pp. 863-869, 2025, DOI:10.32604/jpa.2025.073522 - 30 December 2025

Abstract We examined the direct relationship between childhood emotional abuse and depression in adolescents and the mediating roles of resilience and self-efficacy in that relationship. Using a cross-sectional study design, 636 Chinese adolescents (Girls = 48.6%, mean years of service = 15.8, SD = 1.9) completed the Childhood Trauma Questionnaire (CTQ), the Ego-Resiliency Scale (ERS), the General Self-Efficacy Scale (GSES), and the Patient Health Questionnaire-9 (PHQ-9). Mediation analysis revealed that childhood emotional abuse significantly predicted higher levels of depression. Moreover, resilience and self-efficacy were found to mediate this relationship both independently and sequentially. Specifically, resilience accounted More >

Fan Deng^*

Journal of Psychology in Africa, Vol.35, No.6, pp. 797-805, 2025, DOI:10.32604/jpa.2025.068735 - 30 December 2025

Abstract This study investigated the relationship between customer-employee exchange (CEX) and employee work engagement (vigor, dedication, absorption), and the role of psychological safety and self-efficacy mediate that relationship. Survey data were collected from 329 Chinese hotel employees (females = 52.9%, tenure: 1–3 years = 50.5%). The results following ordinary least squares regression and the SPSS PROCESS macro indicate that higher customer-employee exchange is associated with employee vigor, dedication, and absorption. Psychological safety and self-efficacy mediate the relationship between customer-employee exchange and vigor and dedication to be stronger, while the work absorption mediating effect is not significant. More >

MD Hamid Borkot Tulla^1,*, MD Moniur Rahman Ratan², Rashid MD Mamunur³, Abdullah Hil Safi Sohan⁴, MD Matiur Rahman⁵

Journal of Cyber Security, Vol.7, pp. 675-691, 2025, DOI:10.32604/jcs.2025.074737 - 24 December 2025

Abstract Phishing is considered one of the most widespread cybercrimes due to the fact that it combines both technical and human vulnerabilities with the intention of stealing sensitive information. Traditional blacklist and heuristic-based defenses fail to detect such emerging attack patterns; hence, intelligent and transparent detection systems are needed. This paper proposes an explainable machine learning framework that integrates predictive performance with regulatory accountability. Four models were trained and tested on a balanced dataset of 10,000 URLs, comprising 5000 phishing and 5000 legitimate samples, each characterized by 48 lexical and content-based features: Decision Tree, XGBoost, Logistic… More >