QIAO ZHOU1,2,3, JIAN LIU2,4, LING XIN4, YANYAN FANG2,4, LEI WAN2,4, DAN HUANG2,4, JINCHEN GUO1, JIANTING WEN2,4
BIOCELL, Vol.47, No.4, pp. 761-772, 2023, DOI:10.32604/biocell.2023.026698
Abstract The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being obesity, age,
environmental variables, and genetic predisposition. The available evidence suggests that genetic diversity does not
adequately account for all clinical characteristics and heterogeneity of OA. Genetics has emerged as a nascent and
crucial area of research in OA. The epigenetic module presents a potential link between genetic and environmental
risk factors and the susceptibility and pathogenesis of OA. As a critical epigenetic alteration, DNA methylation has
been shown to have an important role in the etiology of OA and is a viable biomarker for predicting disease… More >
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